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Yunnan white powder nanoemulsion and preparation method thereof

A nano-emulsion and Baiyao technology, applied in the field of medicine, can solve the problems of affecting the therapeutic effect, low bioavailability, poor stability, etc., and achieve the effects of improving solubility, simple method and process, and improved anti-corrosion performance.

Inactive Publication Date: 2014-07-30
张晓燕
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, Yunnan Baiyao is insoluble in water, and Yunnan Baiyao tincture, oral liquid, aerosol, etc. are easy to precipitate, have poor stability, poor transdermal property, low absorption rate, and low bioavailability, thereby affecting its therapeutic effect.
And Yunnan Baiyao has certain toxic and side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Accurately weigh 1.079 g of Yunnan Baiyao, add 5.016 g of ethanol, extract and let stand for 24 to 48 hours. Aspirate the supernatant with a pipette, and filter the supernatant with filter paper to form filtrate 1. Filter the medicinal residue and raffinate left after extracting the supernatant with filter paper to form filtrate 2. Combine filtrate 1 and filtrate 2 to form the total filtrate. Mix 2.603 g of ethyl acetate, 2.508 g of Tween-80, the total filtrate, and 2 g of water, and stir to form a clear, transparent yellow nanoemulsion of Yunnan Baiyao.

Embodiment 2

[0043] Accurately weigh 1.048 g of Yunnan Baiyao, add 20 g of ethanol, extract and let stand for 24 to 48 hours. Aspirate the supernatant with a pipette, and filter the supernatant with filter paper to form filtrate 1. Filter the medicinal residue and raffinate left after extracting the supernatant with filter paper to form filtrate 2. Combine filtrate 1 and filtrate 2 to form the total filtrate. Mix 10 g of ethyl acetate, 10 g of Tween-80, total filtrate, and 6 g of water, and stir to form a clear and transparent yellow Yunnan Baiyao nanoemulsion.

Embodiment 3

[0045]Accurately weigh 2 g of Yunnan Baiyao, add 60 g of ethanol, extract and let stand for 24 to 48 hours. Aspirate the supernatant with a pipette, and filter the supernatant with filter paper to form filtrate 1. Filter the medicinal residue and raffinate left after extracting the supernatant with filter paper to form filtrate 2. Combine filtrate 1 and filtrate 2 to form the total filtrate. Mix 32 g of ethyl acetate, 32 g of Tween-80, total filtrate, and 25 g of water, and stir to form a clear and transparent yellow Yunnan Baiyao nanoemulsion.

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Abstract

The invention discloses a Yunnan white powder nanoemulsion. The particle sizes of liquid drops of the nanoemulsion are 10-100nm; the Yunnan white powder nanoemulsion is prepared from the following raw materials by weight: 1-4g of Yunnan white powder, 2.6-5.5g of oil, 2.5-55g of a surfactant, 5-102g of ethanol and 2-30g of water. By adopting the Yunnan white powder, the drug stability of the Yunnan white powder in the processing process can be improved, the transdermal absorption level is increased, the bioavailability is improved, the drug metabolism time inside a body is delayed, the excipients dosage is reduced, the toxic and side effects are reduced, the production cost is reduced, and the Yunnan white powder nanoemulsion has a broad market prospect in the field of medicines.

Description

technical field [0001] The invention belongs to the field of medicine and relates to a Yunnan Baiyao nanoemulsion, in particular to a transparent and stable Yunnan Baiyao nanoemulsion. Background technique [0002] Yunnan Baiyao is known to the world for its hemostatic effect. Because it contains a variety of active ingredients, its pharmacological effects are complex, and it has multiple uses besides hemostasis. [0003] Yunnan Baiyao has obvious curative effects on various bleeding diseases, can accelerate hemostasis and shorten the course of the disease. Studies have shown that the pharmacological effect in this area is mainly to shorten the bleeding time and coagulation time. Yunnan Baiyao can shorten the prothrombin time, increase the content of prothrombin, and induce the aggregation and release of platelets. Hemostasis is also widely used, and it has a good therapeutic effect on traumatic bleeding, gastrointestinal bleeding, respiratory bleeding, hemorrhagic encephal...

Claims

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Application Information

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IPC IPC(8): A61K9/107A61K36/896A61K36/8945A61K47/44A61K47/26A61P29/00A61P17/02A61P7/04A61P17/00A61P31/00
Inventor 张晓燕张虹
Owner 张晓燕
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