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Angelica oil transdermal patch and preparation method thereof

A technology of transdermal patch and angelica oil, applied in the field of medicine, can solve problems such as adverse effects, and achieve the effects of reducing individual differences, reducing toxic and side effects, and being convenient to use

Inactive Publication Date: 2014-08-13
HUBEI HONGTUDI MODERN CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These western medicines inevitably have adverse effects on human endocrine function

Method used

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  • Angelica oil transdermal patch and preparation method thereof
  • Angelica oil transdermal patch and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1: (1) Heat, melt and mix PEG400 4g and PEG4000 5g evenly. (2) Take 4g of angelica oil, heat and mix it with the matrix evenly to make angelica oil ointment. (3) Spread the ointment on the backing film (thickness 0.3mm, area 4cm x6cm or 6cm x8cm), cover the EVA controlled release film (thickness 50μm), and seal it with thermoplastic around it. (4) The pressure-sensitive adhesive is hot-melt coated on the release layer, and the adhesive surface is covered outside the release-controlling film. (5) Sealed in an aluminum-plastic composite film bag and stored in a cool, dark place.

Embodiment 2

[0027] Example 2: (1) Heat, melt and mix PEG400 4g and PEG4000 5g evenly. (2) Take 4g of angelica oil, heat and mix it with the matrix evenly to make angelica oil ointment. (3) Spread the ointment on the backing film (thickness 0.5mm, area 4cm x6cm or 6cm x8cm), cover the EVA controlled release film (thickness 50μm), and seal it with thermoplastic around it. (4) Coat the PEG matrix (thickness 0.2mm) on the outside of the controlled-release membrane, then cover with an anti-adhesive layer, and attach a medical adhesive sticker. (5) Sealed in an aluminum-plastic composite film bag and stored in a cool, dark place.

Embodiment 3

[0028]Example 3: (1) PEG400 40g and PEG4000 50g were heated, melted and mixed uniformly. (2) Take 40g of angelica oil, heat and mix with the matrix evenly to make angelica oil ointment. (3) Spread the ointment on the backing film (thickness 0.4mm, area 4cm x6cm or 6cm x8cm), cover with EVA controlled-release film (thickness 50μm), and seal it with thermoplastic around it. (4) Coat the PEG matrix (thickness 0.2mm) on the outside of the controlled-release membrane, then cover with an anti-adhesive layer, and attach a medical adhesive sticker. (5) Sealed in an aluminum-plastic composite film bag and stored in a cool, dark place.

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Abstract

The invention discloses an angelica oil transdermal patch and a preparation method thereof, which provides a modern TTS (transdermal thrapeutic system) traditional Chinese medicinal preparation to broad women suffering from dysmenorrhea. The patch is characterized in that: angelica oil serving as a raw material and polyethylene glycol serving as a matrix are encapsulated between a lining membrane and a controlled-release membrane to prepare the membrane-controlled transdermal patch for treatment of dysmenorrhea. The patch can release drugs at a constant speed, so that the curative effect is durable and smooth, the acting time of the drug can be prolonged, the number of administration times can be reduced, the compliance of patients can be improved, and thus use of the angelica oil transdermal patch can be stopped at any time. The angelica oil transdermal patch represents the effective, safe, convenient and humanized administration therapeutic characteristics.

Description

1. Technical field [0001] The invention belongs to the technical field of medicine, and relates to an angelica oil transdermal patch for treating dysmenorrhea and a preparation method thereof. 2. Background technology [0002] Dysmenorrhea refers to women who periodically experience spasmodic pain in the lower abdomen, or a sense of bloating, or pain in the lumbosacral region during or after menstruation. In severe cases, it is accompanied by symptoms such as nausea, vomiting, cold limbs, and even severe pain and fainting. Menstrual abdominal pain" category. Clinically, it can be divided into two categories: one is secondary dysmenorrhea caused by definite diseases of genital organs, and the other is primary dysmenorrhea without obvious organic lesions of genital organs. According to literature reports, 80% of women in the world have dysmenorrhea in varying degrees, about 3 / 4 of which affect study and work, and the main occurrence groups are adolescent girls and unmarried o...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K47/34A61K36/232A61P15/00
Inventor 聂诗明徐建中刘合刚左志学颜春潮
Owner HUBEI HONGTUDI MODERN CHINESE MEDICINE
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