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Oral pharmaceutical composition containing cefdinir and preparation method thereof

A technology of cefdinir and composition, which is applied in the field of oral pharmaceutical composition, can solve the problems of moisture and heat instability, and achieve the effect of high formability, high quality and high fluidity

Active Publication Date: 2015-08-26
JIANGSU YABANG QIANGSHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The invention solves the problem that the cefdinir oral preparation is unstable to humidity and heat during the preparation process, is beneficial to reduce and control the impurity content in the cefdinir oral preparation, and improves the quality and stability of the preparation product

Method used

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  • Oral pharmaceutical composition containing cefdinir and preparation method thereof
  • Oral pharmaceutical composition containing cefdinir and preparation method thereof
  • Oral pharmaceutical composition containing cefdinir and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Preparation of cefdinir tablets (dry granulation)

[0035] Prescription composition:

[0036]

[0037] Preparation Process:

[0038] (1) Cefdinir and lactose are respectively crushed and passed through a 200-mesh sieve for standby use, and other auxiliary materials are dried and passed through a 100-mesh sieve for standby use;

[0039](2) Weigh cefdinir, lactose, microcrystalline cellulose, crospovidone of 50% of the recipe and magnesium stearate of 30% of the recipe, mix well;

[0040] (3) extruded into a block by dry method, crushed, granulated by 18 mesh sieve, and granulated by 16 mesh;

[0041] (4) Add the remaining amount of crospovidone and magnesium stearate, mix uniformly, and press into tablets.

Embodiment 2

[0043] Preparation of Cefdinir Tablets (Powder Direct Compression)

[0044] Prescription composition:

[0045]

[0046] Preparation Process:

[0047] (1) Cefdinir crude drug is pulverized and crossed through a 200-mesh sieve for subsequent use;

[0048] (2) all auxiliary materials are dried and passed through a 100-mesh sieve for later use;

[0049] (3) take by weighing the cefdinir, UF711 type microcrystalline cellulose, lactose and hydroxypropyl cellulose of the recipe quantity, mix well;

[0050] (4) After mixing the above-mentioned mixture with magnesium stearate again, carry out tablet compression to obtain.

Embodiment 3

[0052] Preparation of Cefdinir Tablets (Powder Direct Compression)

[0053] Prescription composition:

[0054]

[0055] Preparation Process:

[0056] (1) Cefdinir crude drug is pulverized and crossed through a 200-mesh sieve for subsequent use;

[0057] (2) all auxiliary materials are dried and passed through a 100-mesh sieve for later use;

[0058] (3) take by weighing the cefdinir, UF711 type microcrystalline cellulose, lactose and hydroxypropyl cellulose of the recipe quantity, mix well;

[0059] (4) After mixing the above-mentioned mixture with magnesium stearate again, carry out tablet compression to obtain.

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PUM

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Abstract

The invention discloses an orally-taken medicinal composition containing cefdinir and UF711-type microcrystalline cellulose. A cefdinir orally-taken solid preparation is prepared by a powder direct pellet method. The medicinal composition and preparation method thereof can effectively reduce content of impurities in the cefdinir orally-taken solid preparation, and is beneficial to improving and controlling quality and stability of preparation products.

Description

technical field [0001] The invention relates to an oral pharmaceutical composition containing cefdinir and UF711 type microcrystalline cellulose and a preparation method thereof. Background technique [0002] Cefdinir, chemical name: (6R,7R)-7-[(Z)-2-(2-amino-4-thiazolyl)-2-hydroxyiminoacetamido]-8-oxo-3 -Vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, the chemical structure is shown below: [0003] [0004] Cefdinir is a third-generation oral cephalosporin, which is an oral cephalosporin developed on the basis of cefixime. Its chemical structure is characterized by replacing the hydroxymethoxyimino group on the 7-position side chain of cefixime with hydroxyl imino. Compared with cefixime, ceftibutene, cefpodoxime, and cefaclor, cefdinir has stronger activity against G+ bacteria; while for G- bacteria, its antibacterial activity is similar to cefixime, and significantly better than cefaclor. Cefdinir can be used to treat tonsillitis, sinusitis, otitis medi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/546A61K47/38A61P31/04
Inventor 陈再新王淑娟庄鹏飞赵晓红王勇军王宋方英毛白杨
Owner JIANGSU YABANG QIANGSHENG PHARMA