Traditional Chinese medicine compound composition for treating diarrhea-predominant irritable bowel syndrome and preparation method and preparation thereof
A technology of irritable bowel syndrome and traditional Chinese medicine preparations, applied in the field of medicine, can solve the problems of lack of evidence-based basis for long-term efficacy, tolerance and safety
Active Publication Date: 2014-08-20
TONGDE HOSPITAL OF ZHEJIANG PROVINCE
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Problems solved by technology
[0003] For the treatment of diarrhea-predominant irritable bowel syndrome, Western medicine mainly focuses on symptomatic treatment, often using highly selective L-type calcium ion channel blockers (such as pinaverium bromide, otilonium bromide), antidiarrheal agents (such as loxanthium bromide, etc.) Peramide, compound diphenoxylate, dioctahedral montmorillonite), 5-HT 3 Receptor antagonists (such as alosetron, etc.), probiotics (such as Bifidobacterium, Lactobacillus, Clostridium butyricum), antidepressants (such as amitriptyline, paroxetine), etc., to relieve clinical symptoms , to improve the quality of life, but the above drugs only temporarily relieve one or several symptoms of patients, and lack evidence-based evidence for long-term efficacy, tolerability and safety
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[0026] 1. Efficacy evaluation
[0027] 1) Take 120g of herb, 90g of patchouli, 50g of calamus, 50g of fried berberine, 90g of simmering wood, and 200g of Albizia juniper. Add 6000mL of water, decoct for extraction for 1 hour, and filter; add 3000mL of water to the filter residue, decoct for extraction for 0.5 hour, and filter; combine the two filtrates, heat and concentrate the filtrate to a 600mL concentrate, and set aside.
[0028] 2) Take 35 SD neonatal rats, insert a disposable continuous epidural anesthesia catheter into the anus with paraffin oil lubrication from the 8th day of birth, inject 1 mL of 0.5% acetic acid aqueous solution into the colon, and operate continuously for 8 days. After ~21d, it is reserved.
[0029] 3) Take the experimental rats in step 2) and 10 untreated normal SD rats, and use the colorectal expansion stimulation method to evaluate the intestinal sensitivity, and record the abdominal lifting and arching of the rats respectively The pressure val...
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The invention relates to the field of medicines and particularly relates to a traditional Chinese medicine compound composition for treating diarrhea-predominant irritable bowel syndrome and a preparation method and a preparation thereof. The effective components of the traditional Chinese medicine compound composition for treating diarrhea-predominant irritable bowel syndrome comprise the following raw material medicinal materials in parts by weight: 6-18 parts of prepared rhizoma atractylodis, 4-15 parts of pogostemon cablin, 2-8 parts of rhizoma acori graminei, 2-8 parts of fried coptis chinensis, 6-18 parts of stewed elecampane and 10-30 parts of cortex albiziae. The traditional Chinese medicine compound composition for treating diarrhea-predominant irritable bowel syndrome, which is provided by the invention, provides novel medicine selection and is beneficial to improving and recovering symptoms of the patient. The traditional Chinese medicine compound composition provided by the invention has the effects of reducing the visceral sensitivity, reducing the quantity of mastocytes in colonic mucosa and reducing the ratio of area of mastocytes to caryoplasm.
Description
technical field [0001] The invention relates to the field of medicines, in particular to a traditional Chinese medicine compound composition for treating diarrhea-type irritable bowel syndrome and its preparation method and preparation. Background technique [0002] Irritable bowel syndrome (irritable bowel syndrome, IBS) is one of the most common functional bowel diseases. The disease does not directly increase the mortality and disability rates of patients, but it will significantly affect patients' daily life, study, work, and social interaction, resulting in a large consumption of medical resources and a heavy economic burden on society. The prevalence rate in my country is about 5.6%-11.5%, which is lower than that of western developed countries, but due to the large population base in my country, the total incidence population is quite large. Diarrhea-predominant IBS is the most common subtype of IBS, accounting for about 65%. [0003] For the treatment of diarrhea-p...
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IPC IPC(8): A61K36/888A61P1/12
Inventor 陈明显刘赛月李亚平寿旦傅睿陆拯
Owner TONGDE HOSPITAL OF ZHEJIANG PROVINCE