Magnetic resonance imaging simulating method for irrelevant movement in myocardial microcirculation perfusion voxel

A technology of magnetic resonance imaging and simulation method, applied in special data processing applications, instruments, electrical digital data processing, etc., can solve the problems of difficult evaluation, long evaluation period, and high evaluation cost

Active Publication Date: 2014-09-03
HARBIN INST OF TECH
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Problems solved by technology

[0004] The purpose of the present invention is to solve the problems that the qualitative evaluation method of the in vivo experiment cannot accurately quantify the detection results, and the traditional quanti

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  • Magnetic resonance imaging simulating method for irrelevant movement in myocardial microcirculation perfusion voxel
  • Magnetic resonance imaging simulating method for irrelevant movement in myocardial microcirculation perfusion voxel
  • Magnetic resonance imaging simulating method for irrelevant movement in myocardial microcirculation perfusion voxel

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specific Embodiment approach 1

[0057] Specific Embodiment 1: In this embodiment, the MRI simulation method of incoherent motion in the myocardial microcirculation perfusion voxel is implemented according to the following steps:

[0058] 1. Use the network avoidance equation (1) to make the blood vessel segment to be generated towards the function f 1 (x) grows in the direction of the minimum value;

[0059] f 1 ( x ) = Σ n = 1 N U n | | x - x n | | β v - - - ( 1 ) ...

specific Embodiment approach 2

[0097] Specific embodiment 2: The difference between this embodiment and specific embodiment 1 is the angle θ between the subsection b and the parent section in step 1 2 Calculate according to the following optimal branch angle equation:

[0098] θ 2 = cos - 1 [ 1 r 0 4 + r 2 4 ( r 1 4 + r 2 4 ) 2 ...

specific Embodiment approach 3

[0099] Specific implementation mode 3: The difference between this implementation mode and specific implementation mode 1 or 2 is that step 4 takes 15 to 20 different value.

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Abstract

The invention discloses a magnetic resonance imaging simulating method for irrelevant movement in a myocardial microcirculation perfusion voxel, and belongs to the field of magnetic resonance imaging computer simulating. The method solves the problems that an in vivo experiment qualitative evaluation method cannot precisely quantize the detection effect, and a traditional simulating experiment quantitative evaluation method is large in evaluation difficulty, high in evaluation cost and long in evaluation period. The simulating method comprises the steps that firstly, a network avoidance algorithm, a boundary avoidance algorithm and a fluid branch constraint algorithm are utilized for building a virtual myocardial microcirculation network model; secondly, a blood perfusion model in a blood vessel and a water molecule diffusion movement model outside the blood vessel are built; thirdly, on the basis of the diffusion magnetic resonance imaging principle, an IVIM MRI mechanism is simulated, and a magnetic resonance fading signal is generated; fourthly, nonlinear fitting is performed on the fading signal, and the simulating detection result of the myocardial microcirculation perfusion model is obtained. The method can provide the reliable simulation quantitative evaluation conclusion.

Description

technical field [0001] The invention belongs to the field of magnetic resonance imaging computer simulation. Background technique [0002] Myocardial microcirculation is the blood circulation between arterioles, capillaries and venules, and is an important place for material exchange between myocardial cells and blood. Abnormal myocardial microcirculation perfusion can cause corresponding clinical symptoms such as myocardial ischemia, which seriously threatens human health. Intra-voxel Incoherent Motion Magnetic Resonance Imaging (IVIM MRI) technology is a new microcirculation perfusion imaging method in recent years, which is developed on the basis of diffusion-weighted MRI technology. , the principle is to use the physical phenomenon that the phase of the proton group is seriously incoherent under the action of the diffusion-sensitive gradient of perfused blood flowing in a random direction, generate multiple b-value (attenuation factors) magnetic resonance attenuation si...

Claims

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Application Information

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IPC IPC(8): G06F19/00
Inventor 刘宛予郐子翔黄建平朱跃敏
Owner HARBIN INST OF TECH
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