The invention discloses a magnetic resonance imaging simulating method for irrelevant movement in a myocardial microcirculation perfusion voxel, and belongs to the field of magnetic resonance imaging computer simulating. The method solves the problems that an in vivo experiment qualitative evaluation method cannot precisely quantize the detection effect, and a traditional simulating experiment quantitative evaluation method is large in evaluation difficulty, high in evaluation cost and long in evaluation period. The simulating method comprises the steps that firstly, a network avoidance algorithm, a boundary avoidance algorithm and a fluid branch constraint algorithm are utilized for building a virtual myocardial microcirculation network model; secondly, a blood perfusion model in a blood vessel and a water molecule diffusion movement model outside the blood vessel are built; thirdly, on the basis of the diffusion magnetic resonance imaging principle, an IVIM MRI mechanism is simulated, and a magnetic resonance fading signal is generated; fourthly, nonlinear fitting is performed on the fading signal, and the simulating detection result of the myocardial microcirculation perfusion model is obtained. The method can provide the reliable simulation quantitative evaluation conclusion.