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Application of Radix Scutellariae extract in pharmacy

A technology of Scutellaria baicalensis extract and baicalin, applied in the application field of scutellaria baicalensis extract in pharmaceuticals, can solve the problems of no relevant reports on ischemic protection drugs, achieve considerable expected economic and social benefits, broad market prospects, and low cost cheap effect

Inactive Publication Date: 2014-09-10
张华
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Baicalin (Baicalin), as the main component of traditional Chinese medicine Scutellaria baicalensis, plays an important therapeutic role in many clinical diseases, and its application in cardiovascular diseases has attracted more and more attention from many scholars. pneumonia, myocardial hypoxia, and ischemic protective drugs have not been reported

Method used

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  • Application of Radix Scutellariae extract in pharmacy
  • Application of Radix Scutellariae extract in pharmacy
  • Application of Radix Scutellariae extract in pharmacy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Baicalin tablet: take 5 g of baicalin extract extract, make a solid dispersion with polyethylene glycol 6000 at a ratio of 1:6, add crospovidone, sodium carboxymethyl cellulose, carboxymethyl starch Sodium, pregelatinized starch, magnesium stearate, micropowder silica gel, mixed evenly and pressed into tablets, ready to be obtained.

Embodiment 2

[0030] Baicalin capsules: made into soft capsules by conventional dripping method. Take the extract of baicalin extract, dry it, crush it, make granules, put it into capsules, remember.

Embodiment 3

[0032] Baicalin pills: take the extract of baicalin extract, dry, pulverize, pour into pills with water, dry at low temperature, and coat with sugar, film or charcoal to obtain the product.

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PUM

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Abstract

The invention relates to an application of a Radix Scutellariae extract (with the scutelloside content of 50-95%) in the pharmacy. The Radix Scutellariae extract (with the scutelloside content of 50-95%) is exploited to form medicines for treating pulmonary hypertension. A result of in vitro artery strip experiments shows that the Radix Scutellariae extract can substantially relax potassium chloride contracted pulmonary artery strips; the Radix Scutellariae extract can reduce the rat high pulmonary artery pressure caused by monocrotaline in a concentration-dependent manner; and the Radix Scutellariae extract also can inhibit the smooth muscle cell proliferation of pulmonary artery tunica media and promote the cell apoptosis. A new medical use of the known compound baicalin is excavated in the invention, and a new application field is developed. Researches find that the Radix Scutellariae extract has a very good pulmonary artery pressure reduction effect, can reduce the hypertrophy index of the right heart of the pulmonary artery high pressure rat and reverse the pulmonary artery tunica media reconstruction, and can rise the vein smooth muscle cell apoptosis associated protein Bax and decrease Bcl-2. The Radix Scutellariae extract has the advantages of nontoxic raw material, low price, low cost, safety and high efficiency.

Description

technical field [0001] The invention relates to the new application of the baicalin extract, that is, the baicalin-containing 50-95% baicalin extract, and specifically relates to the application of preparing a medicine for treating pulmonary hypertension and reversing pulmonary artery remodeling. Background technique [0002] The plant source of baicalin is the root of Scutellaria baicalensis Georgi (Scutellaria baicalensis Georgi), molecular formula and molecular weight: C21H18011; 446.36; pharmacological effects: baicalin has anti-inflammatory, anti-allergic, diuretic, choleretic, cholesterol-lowering, anti-thrombotic properties Formation and relief of asthma, purging fire and detoxification, hemostasis, anti-abortion and other functions. It is also a specific inhibitor of mammalian liver sialase, and has the effect of regulating certain diseases. In industry, it is used as a raw material to prepare baicalin orthophosphate for allergy and asthmatic pneumonia, as well as a...

Claims

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Application Information

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IPC IPC(8): A61K36/539A61K31/7048A61P9/12
Inventor 张华
Owner 张华