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Amlodipine besylate oral preparation and preparation method thereof

The technology of amlodipine besylate and amlodipine besylate tablets is applied in the field of medicine and achieves the effects of rapid drug dissolution, improved drug stability and simple preparation process

Inactive Publication Date: 2014-09-24
QINGDAO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Despite improved dissolution and increased stability, liposome technology is complex to prepare

Method used

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  • Amlodipine besylate oral preparation and preparation method thereof
  • Amlodipine besylate oral preparation and preparation method thereof
  • Amlodipine besylate oral preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035]

[0036] Preparation Process:

[0037] (1) Dissolve acrylic resin E in absolute ethanol, adjust the pH to 3.0 with citric acid, add amlodipine besylate, and stir to dissolve;

[0038] (2) adding the liquid paraffin solution containing Span;

[0039] (3) Gradually heat up to 35°C, stir, and filter under reduced pressure to obtain microspheres;

[0040] (4) the microspheres are washed with n-hexane to remove free amlodipine besylate on the surface;

[0041] (5) Mix the microspheres with lactose, crospovidone and magnesium stearate evenly, and press into tablets to obtain.

Embodiment 2

[0043]

[0044] Preparation Process:

[0045] (1) Dissolve acrylic resin E in absolute ethanol, adjust the pH to 7.0 with citric acid, add amlodipine besylate, and stir to dissolve;

[0046] (2) adding the liquid paraffin solution containing Span;

[0047] (3) Gradually heat up to 35°C, stir, and filter under reduced pressure to obtain microspheres;

[0048] (4) the microspheres are washed with n-hexane to remove free amlodipine besylate on the surface;

[0049] (5) Mix the microspheres with lactose, crospovidone and talcum powder evenly, and press into tablets to obtain the product.

Embodiment 3

[0051]

[0052]

[0053] Preparation Process:

[0054] (1) Dissolve acrylic resin E in absolute ethanol, adjust the pH to 5.5 with citric acid, add amlodipine besylate, and stir to dissolve;

[0055] (2) adding the liquid paraffin solution containing Span;

[0056] (3) Gradually heat up to 35°C, stir, and filter under reduced pressure to obtain microspheres;

[0057] (4) the microspheres are washed with n-hexane to remove free amlodipine besylate on the surface;

[0058] (5) Mix the microspheres with microcrystalline cellulose, crospovidone and talcum powder evenly, and press into tablets to obtain the product.

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PUM

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Abstract

An amlodipine besylate oral preparation and a preparation method thereof. Microspheres are prepared from amlodipine besylate and acrylic resin E, and direct tabletting of the microspheres and pharmaceutically acceptable auxiliary materials is carried out to obtain the product.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an oral preparation containing amlodipine besylate and a preparation method thereof. Background technique [0002] Amlodipine besylate is the third-generation long-acting dihydropyridine calcium channel antagonist, which mainly inhibits the calcium storage capacity of myocardial and vascular smooth muscle cell membranes and the ability to combine with calcium ions, allowing extracellular calcium ions to enter through slow channels. The reduction of flow muscle cells directly relaxes vascular smooth muscle, expands vascular arterioles, reduces peripheral resistance, and achieves the effect of lowering blood pressure. It has long half-life, high bioavailability, mild, slow and long-lasting action, few side effects, remarkable curative effect, easy to use, does not affect blood lipid and blood sugar metabolism, and has no damage to liver and kidney functions. The stru...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/4422A61K47/32A61P9/12A61P9/08
Inventor 徐丽洒孙勇袁海成徐平沈若武
Owner QINGDAO UNIV
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