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Application of polymer salvianolic acid in preparation of drugs used for inhibiting occurrence or development of aortic aneurysm or aortic dissection

A technology for aortic dissection and body salvianolic acid, which is applied in the field of medicine and can solve problems that have not yet been seen

Active Publication Date: 2014-09-24
SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

It has a certain effect on angina pectoris and acute myocardial infarction, sequelae of cerebral thrombosis, scleroderma, central retinal artery embolism, neurological deafness, leukotrichia syndrome and erythema nodosum, etc., but no salvianolic acid A or other Research report on salvianolic acid used in the treatment of aortic aneurysm or aortic dissection

Method used

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  • Application of polymer salvianolic acid in preparation of drugs used for inhibiting occurrence or development of aortic aneurysm or aortic dissection
  • Application of polymer salvianolic acid in preparation of drugs used for inhibiting occurrence or development of aortic aneurysm or aortic dissection
  • Application of polymer salvianolic acid in preparation of drugs used for inhibiting occurrence or development of aortic aneurysm or aortic dissection

Examples

Experimental program
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Embodiment Construction

[0020] Experimental example

[0021] 1. Biacore detection of direct binding of multimeric salvianolic acid to MMP-9 protein

[0022] Obtain MMP-9 catalytic domain protein by protein recombination technology, and verify that the protein has the ability to degrade collagen and other substrates, and then use surface plasmon resonance technology (Biacore3000 instrument) to investigate and evaluate the representative phenolic acid and MMP in polymer salvianolic acid -9 direct binding ability of catalytic domain proteins.

[0023] 2. Enzyme kinetic screening test

[0024] The fluorescent polypeptide thiopeptolide (purchased from Bachem Bioscience) was used as the fluorescent substrate of MMP-9 to investigate different concentrations of salvianolic acid (salvianolic acid A, salvianolic acid B, salvianolic acid C, shikoninic acid, protocatechualdehyde, salvia miltiorrhiza Inhibitory activity of salvianolic acid and rosmarinic acid) on MMP-9, and the double reciprocal method was used...

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Abstract

The invention relates to application of polymer salvianolic acid in preparation of drugs used for inhibiting occurrence or development of aortic aneurysm or aortic dissection and a pharmaceutical composition comprising the polymer salvianolic acid used as a pharmaceutical active substance, related desired adjuvant and the like. The pharmaceutical composition can be used for inhibiting occurrence of aortic aneurysm or aortic dissection. The polymer salvianolic acid is dimer salvianolic acid, trimer salvianolic acid or tetramer salvianolic acid, wherein the dimer salvianolic acid is rosmarinic acid, the trimer salvianolic acid is salvianolic acid C, alkannic acid or salvianolic acid A, and the tetramer salvianolic acid is salvianolic acid B.

Description

technical field [0001] The present invention relates to the field of medicines, in particular to multimer salvianolic acid, especially dimer salvianolic acid, trimer salvianolic acid and tetramer salvianolic acid used in the preparation of anti-aortic aneurysm or aortic The use of medicines in the occurrence of dissection. Background technique [0002] As we all know, salvianolic acid (hereinafter referred to as salvianolic acid) is a kind of water-soluble compound extracted from Salvia miltiorrhiza Bunge, a plant of Labiatae. dimers, trimers and tetramers. Among them, danshensu and protocatechualdehyde are representatives of monomer; rosmarinic acid is representative of dimer; shikonic acid, salvianolic acid A and salvianolic acid C are representatives of trimer; representative of tetramers. The structures of these representative compounds are as figure 1 shown. [0003] Aortic aneurysm and aortic dissection are two important diseases of aortic disease. Aortic aneurys...

Claims

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Application Information

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IPC IPC(8): A61K31/216A61K31/343A61P9/00
Inventor 果德安姜宝红
Owner SHANGHAI INST OF MATERIA MEDICA CHINESE ACAD OF SCI
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