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A kind of wall-breaking preparation of Polygonum cuspidatum

A preparation and technology of Polygonum cuspidatum, which is applied in the field of Polygonum cuspidatum broken wall preparations, can solve the problems of loss of active ingredients, destruction of active ingredients, sensitivity to heat and light, etc. Effect

Active Publication Date: 2016-12-28
ZHONGSHAN ZHONGZHI PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is the dried rhizome and root of Polygonum cuspidatum Sieb.et Zucc., which has the functions of dampness and yellowing, heat-clearing and detoxification, stasis and pain relief, cough and phlegm, and its active ingredients are mainly free anthraquinones and anthraquinone glycosides. Mainly contain emodin and polydatin, which are relatively sensitive to heat and light, and have poor thermal stability
Therefore, if the traditional decocting method is adopted, it is easy to destroy its active ingredients or cause the loss of active ingredients.
The preparation of Polygonum cuspidatum into superfine powder of Polygonum cuspidatum is conducive to improving the utilization rate of active ingredients, but at the same time, due to the increase of the specific surface area of ​​the powder, it has the disadvantages of easy moisture absorption, oxidation, deterioration, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Take the net medicinal material of Polygonum cuspidatum, coarsely pulverize it into a coarse powder of about 100 meshes, and then ultrafinely pulverize it into a powder in which 90% of the particles in the ultrafine powder have a particle size less than or equal to 39 μm, add ethanol-water solution (the mass fraction of ethanol is 30 %) Wet process soft materials, the ratio of solution to superfine powder is 0.4︰1 (by weight), after mixing, pre-installed 10-mesh sieve, the extrusion speed is 50r / min, and the extrusion force is 1MPa to make wet Granules, wet granules are transferred to a hot air circulation oven, set the drying temperature to 75°C, and dried for 2.5 hours to dryness.

[0024]

[0025] Note: The full score is 10.

Embodiment 2

[0027] Take the net medicinal material of Polygonum cuspidatum, coarsely pulverize it into a coarse powder of about 100 meshes, and then ultrafinely pulverize it into a powder in which 90% of the particles in the ultrafine powder have a particle size less than or equal to 39 μm, add ethanol-water solution (the mass fraction of ethanol is 40 %) Wet process soft material, the ratio of solution to superfine powder is 0.5︰1 (by weight), after mixing, pre-installed 10-mesh sieve, the extrusion speed is 60r / min, and the extrusion force is 0.9MPa. Wet granules, the wet granules were transferred to a vacuum microwave drying oven, the drying temperature was set at 45°C, dried for 0.75h until dry, and the whole granule was sieved to obtain the broken wall preparation of Polygonum cuspidatum.

[0028]

[0029] Note: The full score is 10.

Embodiment 3

[0031] Take the net medicinal material of Polygonum cuspidatum, coarsely pulverize it into a coarse powder of about 100 meshes, and then ultrafinely pulverize it into a powder in which 90% of the particles in the ultrafine powder have a particle size less than or equal to 39 μm, add ethanol-water solution (the mass fraction of ethanol is 50 %) Wet process soft material, the ratio of solution to superfine powder is 0.6︰1 (by weight), after mixing, it is pre-installed with a 20-mesh sieve, and the extrusion speed is 80r / min, and the extrusion force is 0.7MPa. Wet granules, wet granules are transferred to a hot air circulation oven, set the drying temperature to 75°C, and dried for 2.5 hours to dryness.

[0032]

[0033] Note: The full score is 10.

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Abstract

The invention relates to a traditional Chinese medicine preparation, in particular to a wall-breaking preparation of Polygonum cuspidatum. According to the invention, by crushing Polygonum cuspidatum into ultra-fine powder, further granulating by ethanol-water wet method, extruding and drying at a certain speed, the prepared Polygonum cuspidatum broken wall preparation has a high bioavailability, Moreover, the preparation has strong stability and good disintegration.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a wall-breaking preparation of Polygonum cuspidatum. Background technique [0002] Ultrafine pulverization technology is a new technology developed rapidly in recent years. Most of the active ingredients in Chinese herbal medicines are distributed in the cells. Conventional decoction pieces can only release part of the active ingredients, and the utilization rate of active ingredients is 10-30%. However, using the wall-breaking crushing technology, such as crushing Chinese herbal medicine pieces to 300 mesh About 86.7% of the cell wall breaking rate will increase the dissolution of the active ingredients in the medicinal materials, greatly enhance its efficacy, and the utilization rate of the active ingredients will be above 90%, so as to reduce the amount of medicinal materials used and protect the medicinal materials resources. The quality increases the efficacy. H...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/704A61K47/10A61K9/16A61P31/00A61P29/00A61P11/14A61P11/10A61J3/00
Inventor 成金乐徐吉银苏观凤陈勇军陈金梅唐琳
Owner ZHONGSHAN ZHONGZHI PHARMA GRP
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