Wall-broken tall gastrodia tuber preparation

A technology of Gastrodia elata and preparation, which is applied in the field of Gastrodia elata broken wall preparation, which can solve the problems of easy loss of drug effect, easy oxidation of broken wall powder, and low stability, so as to achieve easy disintegration and dispersion, easy to drink with warm boiled water, and stable finished product strong effect

Inactive Publication Date: 2014-09-24
ZHONGSHAN ZHONGZHI PHARMA GRP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The technical problem to be solved by the present invention is to overcome the defects in the prior art that the broken wall powder is easy to be oxidized, the stability is not high, and the drug effect is easy to lose, and a kind of gastrodia elata broken wall preparation is provided.

Method used

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  • Wall-broken tall gastrodia tuber preparation
  • Wall-broken tall gastrodia tuber preparation
  • Wall-broken tall gastrodia tuber preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Take Gastrodia elata, coarsely pulverize it into a coarse powder of about 100 meshes, and ultrafinely pulverize it into a powder in which 90% of the particles in the ultrafine powder have a particle size less than or equal to 35 μm, and add ethanol-water solution (the mass fraction of ethanol is 50% ) soft material by wet method, the ratio of solution to superfine powder is 0.3:1 (by weight), after mixing, pre-installed 10-mesh sieve, the extrusion speed is 50r / min, and the extrusion force is 1MPa to make wet granules , the wet granules were transposed into a hot air circulation oven, the drying temperature was set at 70°C, and dried for 2.5 hours until dry.

[0023] Note: The full score is 10.

Embodiment 2

[0025] Take Gastrodia elata, coarsely pulverize it into a coarse powder of about 100 meshes, and ultrafinely pulverize it into a powder in which 90% of the particles in the ultrafine powder have a particle size less than or equal to 35 μm. Add ethanol-water solution (the mass fraction of ethanol is 70% ) soft material by wet method, the ratio of solution to superfine powder is 0.5:1 (by weight), after mixing, pre-installed 10-mesh sieve, the extrusion speed is 60r / min, and the extrusion force is 0.8MPa to make wet Granules, wet granules were transferred to a vacuum microwave drying oven, set the drying temperature to 45°C, dried for 0.75h until dry, and sieved to obtain Gastrodia elata wall-broken preparation.

[0026] Note: The full score is 10.

Embodiment 3

[0028] Take Gastrodia elata, coarsely pulverize it into a coarse powder of about 100 meshes, and ultrafinely pulverize it into a powder in which 90% of the particles in the ultrafine powder have a particle size less than or equal to 35 μm, add ethanol-water solution (the mass fraction of ethanol is 90%) ) soft material by wet method, the ratio of solution to superfine powder is 0.8:1 (by weight), after mixing, pre-installed 30-mesh sieve, the extrusion speed is 80r / min, and the extrusion force is 0.3MPa to make wet Granules, wet granules are transferred to a hot air circulation oven, set the drying temperature to 70°C, and dried for 2.5 hours until dry.

[0029] Note: The full score is 10.

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Abstract

The invention relates to the technical field of Chinese herbal preparations, specifically to a wall-broken tall gastrodia tuber preparation. The wall-broken tall gastrodia tuber preparation is prepared by crushing tall gastrodia tuber into wall-broken powder, then carrying out ethanol-water wet granulation, carrying out extrusion forming at a certain rotating speed and then carrying out drying. The prepared wall-broken tall gastrodia tuber preparation has high bioavailability, good stability and good disintegration performance.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a Gastrodia elata wall-breaking preparation. Background technique [0002] Ultrafine pulverization technology is a new technology developed rapidly in recent years. Most of the active ingredients in Chinese herbal medicines are distributed in the cells. Conventional decoction pieces can only release part of the active ingredients, and the utilization rate of active ingredients is 10-30%. However, using the wall-breaking crushing technology, such as crushing Chinese herbal medicine pieces to 300 mesh About 86.7% of the cell wall breaking rate will increase the dissolution of the active ingredients in the medicinal materials, greatly enhance its efficacy, and the utilization rate of the active ingredients will be above 90%, so as to reduce the amount of medicinal materials used and protect the medicinal materials resources. The quality of the drug increases ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8988A61K9/16A61K47/10A61J3/00
Inventor 成金乐陈勇军钱锦花苏观凤唐琳
Owner ZHONGSHAN ZHONGZHI PHARMA GRP
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