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Alpinia zerumbet volatile oil dropping pill and preparation method thereof

A technology of ginger volatile oil and oil drop pills, which is applied in the field of Yanshan ginger volatile oil drop pills and its preparation, can solve the problems of decreased bioavailability, and achieve the effect of fast action, high curative effect, and easy dissolution

Active Publication Date: 2014-09-24
GUIZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The present invention has a superior therapeutic effect on vascular endothelial cell damage, so it has the curative effect of treating cardiovascular diseases such as regulating qi and resuscitating, promoting blood circulation, promoting qi and relieving pain, etc. The bioavailability declines in the neutral matrix, and the prepared drop pills are round and uniform, with consistent color and no adhesion

Method used

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  • Alpinia zerumbet volatile oil dropping pill and preparation method thereof
  • Alpinia zerumbet volatile oil dropping pill and preparation method thereof
  • Alpinia zerumbet volatile oil dropping pill and preparation method thereof

Examples

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Effect test

Embodiment 1

[0060]Embodiment 1: a kind of preparation method of Alpinia volatile oil dripping pills, get 150g of Alpinia officinalis fruit, steam distillation, or supercritical extraction method extraction, obtain the volatile oil of Alpinia officinalis, for subsequent use; Get the quality of Alpinia officinalis volatile oil 2.38 times the polyethylene glycol 6000 and 1.12 times the polyethylene glycol 4000, mix evenly until there are no bubbles, completely melted, and then put it on a water bath at 49-60°C to keep warm, and then add 4% of the matrix Tween 80, Mix evenly, then add the volatile oil of Alpinia japonicus to dissolve completely, stir and mix evenly, drop into the condensate to make drop pills, wipe off the condensate on the surface of the drop pills, and the finished product is obtained. The method of taking is oral or oral administration, 3 times a day, 1-3 capsules each time.

Embodiment 2

[0061] Embodiment 2: Get 2.38 times of Polyethylene Glycol 6000 and 1.12 times of Polyethylene Glycol 4000 of the volatile oil quality of Alpinia japonicus, fully stir, mix evenly, then put 49-60 ℃ of water baths to insulate, then add dropping pill matrix 6% Tween 80, mix evenly, then add the volatile oil of Alpinia japonicus to dissolve completely, stir and mix evenly, drop into the condensate to make drop pills, wipe off the condensate on the surface of the drop pills, and the finished product is obtained . The method of taking is oral or oral administration, 3 times a day, 1-3 capsules each time.

Embodiment 3

[0062] Embodiment 3: get 150g of Alpinia officinalis medicinal material and put in the extraction kettle of supercritical fluid extraction machine to extract, collect the volatile oil of Alpinia officinalis, for subsequent use; Filter with a device to separate the liquid on the membrane from the liquid below the membrane. The liquid on the membrane is discarded, and the liquid below the membrane is the volatile oil of Alpinia japonicus for future use. Take Polyethylene Glycol 6000 1-5 times and 1-3 times Polyethylene Glycol 4000 of the quality of the volatile oil of Alpinia japonicus, fully stir in a water bath at 60-100°C until there are no bubbles and completely melt, and then place in 49- Keep warm on a water bath at 60°C, then add Span-type co-solvents, mix well, add the above-mentioned volatile oil of Alpinia japonicus to dissolve completely, stir and mix evenly, drop into the condensate to make drop pills, and wipe off the condensation on the surface of the drop pills Li...

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Abstract

The invention discloses an alpinia zerumbet volatile oil dropping pill and a preparation method thereof. The alpinia zerumbet volatile oil dropping pill comprises alpinia zerumbet volatile oil, a mixed matrix and a cosolvent, wherein the mass ratio of the alpinia zerumbet volatile oil to the mixed matrix is 1: (2-8); the mixed matrix is prepared by polyethylene glycol 6000 or polyethylene glycol 4000 in a mass ratio of (1-7): (1-6). The alpinia zerumbet volatile oil dropping pill has a superior curative effect of regulating vital energy to induce resuscitation, promoting blood circulation to remove meridian obstruction, promoting qi circulation to relieve pain and the like, has a remarkable function of protecting the blood vessel endothelium against damage; meanwhile, the problem that the bioavailability is decreased as the volatile oil belongs to a fat-soluble constituent and is not easy to be soluble in water-soluble matrixes, and the prepared dropping pill is round and uniform, consistent in color and free of adhesion phenomenon.

Description

technical field [0001] The present invention relates to a kind of qi-regulating and resuscitating, promoting blood circulation and unblocking collaterals, promoting qi and relieving pain, treating cardiovascular diseases, and protecting vascular endothelial cell damage, myocardial ischemia or infarction, and a preparation method thereof, which belongs to the technical field of pharmacy . Background technique [0002] Cardiovascular system disease is the most common human disease, the number one killer threatening human health, and has become the number one cause of death in the world today. In my country, with the acceleration of population aging, the improvement of people's living standards, the accelerated pace of life, and the development of diet structure towards high fever and high fat, coronary heart disease, angina pectoris and other cardiovascular system diseases have become serious threats to human health and life. One of the diseases, patients with cardiovascular d...

Claims

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Application Information

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IPC IPC(8): A61K36/9062A61K47/34A61K9/20A61P9/00A61P9/14A61P9/10
Inventor 沈祥春陶玲张彦燕令狐克刚林丹
Owner GUIZHOU MEDICAL UNIV
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