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Separable microneedle system and manufacturing method thereof

A separate, micro-needle technology, which is applied in the direction of micro-needles, needles, and other medical devices, can solve the problems of uncontrollable drug release rate and drug loading, user discomfort, etc.

Active Publication Date: 2014-10-01
厦门薇针医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The technical problem to be solved by the present invention is: the substrate of the existing microneedle is integrated with the microneedle. After the microneedle penetrates the skin, the hard substrate must be pressed on the skin surface, and the substrate can only be peeled off after the drug injection is completed. , which brings discomfort to the user, and it is not easy to control the release rate and drug loading of the drug

Method used

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  • Separable microneedle system and manufacturing method thereof
  • Separable microneedle system and manufacturing method thereof
  • Separable microneedle system and manufacturing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] A method for manufacturing an adhesive detachable microneedle has the following steps:

[0054] (1) Making a microneedle array master mold 10 made of SU-8 material by photolithography;

[0055] a) Use AUTOCAD to draw the microneedle array base pattern, and make a mask. The microneedle base pattern of the microneedle array base pattern is 300 μm long, 200 μm wide, and the gap between the microneedles is 500 μm.

[0056] b) Prepare a K9 glass wafer as a glass substrate, and sputter a layer of 300 nm thick metal chromium (Cr) on the glass substrate;

[0057] c) Then spin-coat a layer of BP212-37s positive photoresist with a thickness of 2 microns, expose it with the mask made in step 1), develop it with 0.5% sodium hydroxide developer, and bake it at 100 °C for 5 minutes to obtain patterned photoresist mask;

[0058] d) Then use CR-14 etching solution to etch metal chromium (Cr), and then use acetone to remove the photoresist mask to obtain a Cr mask, so as to transfer t...

Embodiment 2

[0071] The manufacturing method of the needle groove type separable microneedle system has the following steps:

[0072] (1) Making a microneedle array master mold 10;

[0073] (2) Making a microneedle female mold 5;

[0074] (3) Filling the microneedle prepolymer solution in the microneedle groove of the microneedle female mold 5 and curing it;

[0075] (4) Press the microneedle female mold 5 on the viscous transfer plate 7 to transfer the microneedle 1 to the viscous transfer plate 7;

[0076] (5) Using the viscous transfer plate 7 to transfer the microneedle 1 to the transfer mold 8, the depth of the microneedle groove of the transfer mold 8 is smaller than the depth of the microneedle groove of the microneedle female mold 5;

[0077] (6) Transfer the microneedles 1 in the transfer mold 8 to the substrate 2 engraved with needle grooves, insert the microneedles 1 into the needle grooves, and separate from the microneedle female mold 5 together with the substrate 2, and obt...

Embodiment 3

[0083] The manufacturing method of the multi-row assembled adhesive detachable microneedle system: (1) Use dissolvable materials such as silk fibroin and maltose materials to prepare coplanar microneedle arrays 9, and the thickness of the coplanar microneedle arrays 9 is less than Its width; (2) Multiple coplanar microneedle arrays 9 are vertically or obliquely embedded in the needle grooves of the substrate 2, the needle grooves correspond to the shape of the microneedle bases of the coplanar microneedle arrays 9, and are fixed with an adhesive to obtain different Planar microneedle arrays.

[0084]Such as Figure 7 As shown, the method of using the adhesive multi-row assembled separable microneedle system: (1) Squeeze the substrate 2 to make the coplanar microneedle array 9 penetrate the skin 4; (2) Translate the substrate 2 to make the coplanar microneedle array 9 Break at the bonding place; (3) The coplanar microneedle array 9 stays in the skin 4 after breaking and slowly...

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Abstract

The invention relates to the technical field of the microneedles for the medical cosmetology and in particular relates to a separable microneedle system and a manufacturing method thereof. The separable microneedle system comprises a microneedle and a substrate; the microneedle is detachably fixed on the substrate; when the microneedle penetrates into the skin, the microneedle is separated from the substrate so that the microneedle is remained in the skin. The separable microneedle system has the beneficial effects that the microneedle is made of a biocompatible and degradable material, has enough mechanical strength so as to smoothly pierce the skin and can be remained in the skin for procedural degradation; active substances are stable in activity in the microneedle is made of the biocompatible and degradable material, so that the medicine can be released controllably for a long time in the injection point; the microneedle substrate can be made of a flexible material, the hard microneedle can be separated from the flexible substrate, and after the microneedle penetrates into the skin, the microneedle is removed and the separated microneedle is continuously remained in the skin so that the internal active substances can be controllably dissolved and released.

Description

technical field [0001] The invention relates to the technical field of microneedles for medical cosmetology, in particular to a detachable microneedle system and a manufacturing method thereof. Background technique [0002] Transdermal drug delivery is widely used as an effective way for drug delivery because it can avoid the degradation of polymers in the gastrointestinal tract and is convenient to use. Conventionally, external preparations containing medicinal ingredients have been used in order to subcutaneously exert pharmacological effects of the medicinal ingredients. As such external preparations, liquid preparations, ointments, cream preparations, adhesive tape preparations, patches, poultices, etc. are known, and by applying or sticking them locally, the medicinal ingredients are absorbed percutaneously and subcutaneously exert the expected pharmacological effect. However, the above-mentioned external preparations in the form of coating or sticking have the follow...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M37/00
CPCA61M37/0015A61M2037/0046
Inventor 游学秋王志峰商院芳
Owner 厦门薇针医药科技有限公司
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