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Body Fluid Raman Spectroscopy Detection Device

A technology of Raman spectrum detection and laser detection, which is applied in the directions of Raman scattering and material excitation analysis, can solve the problems of limited application, lack, and inability to meet the non-contact, non-destructive, fast and accurate detection requirements of samples, and achieve the detection time Short, fast detection and easy to use

Active Publication Date: 2017-01-18
THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, there is currently a lack of relevant devices and methods for Raman spectroscopic analysis and testing of body fluid samples, especially blood samples, so it cannot meet the non-contact, non-destructive, fast and accurate detection requirements of import and export inspection and quarantine and on-site criminal investigation detection, which also limits Its application in various fields

Method used

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  • Body Fluid Raman Spectroscopy Detection Device
  • Body Fluid Raman Spectroscopy Detection Device
  • Body Fluid Raman Spectroscopy Detection Device

Examples

Experimental program
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Effect test

Embodiment 1

[0034] Embodiment 1: As shown in the figure, the body fluid Raman spectroscopy detection device of this embodiment includes a sample tube and a sample cell;

[0035] The sample tube includes a tube body 1 and a tube cover 2, and a surface-enhanced Raman scattering chip module 10 is arranged on the side of the tube body 1; in a specific embodiment, the surface-enhanced Raman scattering chip module 10 can be combined with The sample tube is made into one piece, or connection structures such as socket slots can be provided on the side of the tube body 1 to fix the surface-enhanced Raman scattering chip module 10; meanwhile, in specific implementation, the sample tube can be a cylindrical tube or a rectangular parallelepiped tube and other shapes.

[0036] The sample cell includes a sample cell seat 3, a sample holder 4 arranged in the sample cell seat 3, a sample cell cover 5 detachably connected to the sample cell seat 3, and a drive for driving the sample holder 4 to rotate aro...

Embodiment 2

[0048] Embodiment two: if Figure 7 As shown, the difference between this embodiment and Embodiment 1 is that the sample holder 4 is provided with a horizontal fixing device 21 for laterally fixing the sample tube on the sample holder, and the sample cell cover 5 is provided with a vertical Raman laser entrance 22. In this embodiment, the horizontal fixing device 21 is a horizontal sample tube slot provided at the upper end of the sample rack 4 . The other structures of this embodiment are the same as those in Embodiment 1, and will not be repeated here. Reference 1 is applicable to a Raman laser detection instrument in which laser light is projected from the horizontal direction, while the embodiment is applicable to a Raman laser detection instrument in which laser light is projected from top to bottom.

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Abstract

The invention discloses a body fluid Raman spectrum testing device which comprises sample tubes and a sample pool, wherein the sample tubes comprise tube bodies and tube caps; laser testing windows and surface strengthening Raman scattering chip modules are arranged on the side surfaces of the tube bodies; the sample pool comprises a sample pool seat, a sample frame, a sample pool cover and a driving device; vertical fixing devices of the sample tubes are arranged on the sample frame, and a horizontal Raman laser incident opening are formed in the sample pool seat; or the horizontal fixing devices of the sample tubes are arranged on the sample frame, and the vertical Raman laser incident opening is formed in the sample pool cover. When tested, body liquid samples are contained in the sample tubes, the sample tubes are inserted into the sample frame, and coated with the sample pool cover, so that the body liquid samples, such as blood, sweat, saliva and urine, can be tested; as the sample frame is driven to rotate through the driving device, the multiple samples can be tested rapidly; the testing time is short. Therefore, the testing requirements that the samples of import and export inspection and quarantine and scene criminal investigation test can be ensured to be non-contacting, non-damaging, fast and accurate can be met.

Description

technical field [0001] The invention relates to a Raman spectrum detection device, in particular to a body fluid Raman spectrum detection device. Background technique [0002] When biological tissues are in different states or physiological conditions change, metabolites inside and outside the body will be reflected in body fluids, and the detection and diagnosis of their states by analyzing the components of biological body fluids is a research hotspot in domestic and foreign academic circles. [0003] At present, technical means for identification of body fluids include microscopic examination of cell types and sizes in body fluids, identification by gas chromatography-liquid chromatography and mass spectrometry, and detection and analysis of body fluid components by enzyme-linked immunosorbent assays and other methods. However, these detection methods have different problems and bottlenecks such as high false positive rate, complicated test methods, expensive instruments,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/65
Inventor 刘小红府伟灵黄君富王云霞
Owner THE FIRST AFFILIATED HOSPITAL OF THIRD MILITARY MEDICAL UNIVERSITY OF PLA