Novel medical functional polyethylene glycol material

Abstract

The invention discloses a novel medical functional polyethylene glycol material. A preparation method for the novel medical functional polyethylene glycol material comprises the steps of by taking ethylene oxide as material, synthesizing three-arm polyethylene glycol by utilizing alkaline-process ring opening; preparing a macro-initiator; carrying out ring-opening polymerization with octodecane esterbenzyl ester carboxylic acid anhydride glutamate (NCA) to obtain star block polymers taking octodecane ester benzyl ester polyglutamate with PEG (polyethylene glycol) as core as arms to obtain star polyethylene glycol / octodecane ester polyglutamate block polymers; adding low molecular weight octodecane ester polyglutamate, dissolving the low molecular weight octodecane ester polyglutamate in water by utilizing amphipathicity of the block polymers to form a nano-scale porous material. The block copolymers have hexagonal columnar structures, continuous phase is polyethylene glycol, and the material has nano-scale holes. The material has the following advantages that the material has nano-scale micro holes, overcomes the defect that the conventional linear polyethylene glycol material is poor in processing performance, is free of toxic and side effect, can be used as a drug carrier material, can be used as a medical implanting material, and can be used as a part material of an in-vivo lasting dosing device.

Description

technical field [0001] The invention relates to a biocompatible and degradable porous polyethylene glycol material, in particular to a preparation method of a block macromolecule material with nanoscale micropores. The invention belongs to the field of polymer chemistry and polymer technology. Background technique [0002] Polylactic acid (PLA) is a new generation of fully degradable polymer materials developed rapidly in the 1990s. It has excellent biocompatibility and is approved by the US Food and Drug Administration (FDA). A class of biomedical materials and environmental protection materials. Since the 1960s, scientists began to pay attention to the degradation performance of polylactic acid materials, and for the first time used polylactic acid materials as degradable surgical suture materials. In 1966, Kulkarni et al. (Kricheldorf H. R. Chemosphere 2001, 43, 49-54. It was first proposed that low molecular weight PLA can be degraded in vivo, and the final metabolit...

AI Technical Summary

Problems solved by technology

Through our review of literature, there is no polylactic acid material that has the characteristics of high processing performance, hydrophilicity, excellent biodegradability, nanoscale micropores, and high drug loading capacity.

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