Rhodamine structure based Cu<2+> fluorescent probe and preparation method thereof

A fluorescent probe, structural formula technology, applied in fluorescence/phosphorescence, chemical instruments and methods, luminescent materials, etc., can solve the problems of poor anti-interference, insufficient solvent applicability, etc., to achieve enhanced anti-interference, improved solvent applicability, Open loop easy effect

Inactive Publication Date: 2014-10-08
KUNSHAN DONGDA ZHIHUI TECH CONSULTANT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The technical problem to be solved by the present invention is that for Cu in the prior art 2+ Detect the above-mentioned defects such as insufficient solvent applicability and poor anti-interference of fluorescent probes, and provide a rhodamine-based Cu with good solvent applicability and strong anti-interference 2+ Fluorescent probe and preparation method thereof

Method used

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  • Rhodamine structure based Cu&lt;2+&gt; fluorescent probe and preparation method thereof
  • Rhodamine structure based Cu&lt;2+&gt; fluorescent probe and preparation method thereof
  • Rhodamine structure based Cu&lt;2+&gt; fluorescent probe and preparation method thereof

Examples

Experimental program
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Embodiment 1

[0033] A kind of Cu based on rhodamine structure 2+ Fluorescent probe, its structural formula is as shown in formula (1):

[0034]

[0035] In this embodiment, the xanthene ring at the top of the above formula (1) is further provided with a hydrocarbon substituent.

[0036] The present embodiment also provides Cu based on the rhodamine structure of the above structural formula 2+ The preparation method of fluorescent probe, its synthetic route is as follows:

[0037]

[0038] According to the above synthetic route, the Cu based on rhodamine structure 2+ The preparation method of fluorescent probe comprises the following process steps:

[0039] (1) Preparation of rhodamine B hydrazide: rhodamine B hydrazide is prepared by using rhodamine B to obtain rhodamine B hydrazide;

[0040] (2) Preparation of rhodamine B hydrazide suspension: add 2.28 g of rhodamine B hydrazide obtained in step (1) and 3.6 ml of tetrahydrofuran into a reaction vessel, grind for 8 minutes and co...

Embodiment 2

[0045] This embodiment is basically the same as Embodiment 1, and there are differences in the preparation method between the two, as follows:

[0046] According to the above synthetic route, the Cu based on rhodamine structure 2+ The preparation method of fluorescent probe comprises the following process steps:

[0047] (1) Preparation of rhodamine B hydrazide: rhodamine B hydrazide is prepared by using rhodamine B to obtain rhodamine B hydrazide;

[0048] (2) Preparation of rhodamine B hydrazide suspension: add 2.28 g of rhodamine B hydrazide obtained in step (1) and 4 ml of tetrahydrofuran into a reaction vessel, grind for 5 minutes and cool to 0°C to obtain rhodamine B hydrazide suspension;

[0049] (3) Preparation of acryloyl chloride suspension: 0.5ml of acryloyl chloride was dissolved in 2ml of tetrahydrofuran to obtain acryloyl chloride suspension;

[0050] (4)Cu 2+ Fluorescent probe preparation: add the acryloyl chloride suspension prepared in step (3) to the rhod...

Embodiment 3

[0053] This embodiment is basically the same as Embodiment 1, and there are differences in the preparation method between the two, as follows:

[0054] According to the above synthetic route, the Cu based on rhodamine structure 2+ The preparation method of fluorescent probe comprises the following process steps:

[0055] (1) Preparation of rhodamine B hydrazide: rhodamine B hydrazide is prepared by using rhodamine B to obtain rhodamine B hydrazide;

[0056] (2) Preparation of rhodamine B hydrazide suspension: add 2.28 g of rhodamine B hydrazide obtained in step (1) and 4.4 ml of tetrahydrofuran into a reaction vessel, grind for 4 minutes and cool to 0°C to obtain rhodamine B hydrazide Hydrazine suspension;

[0057] (3) Preparation of acryloyl chloride suspension: 0.55ml of acryloyl chloride was dissolved in 2.2ml of tetrahydrofuran to obtain acryloyl chloride suspension;

[0058] (4)Cu 2+ Fluorescent probe preparation: add the acryloyl chloride suspension prepared in step ...

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Abstract

The invention discloses a rhodamine structure based Cu<2+> fluorescent probe and a preparation method thereof. A structural formula of the rhodamine structure based Cu<2+> fluorescent probe is shown in the description. The preparation method of the rhodamine structure based Cu<2+> fluorescent probe comprises the steps of preparing rhodamine B hydrazide, preparing a rhodamine B hydrazide suspension, preparing an acryloyl chloride suspension, preparing a Cu<2+> fluorescent probe, and carrying out surface cleaning on Cu<2+> fluorescent probe Mrh. According to the rhodamine structure based Cu<2+> fluorescent probe and the preparation method thereof, the Cu<2+> fluorescent probe has good solvent applicability and high anti-interference property.

Description

technical field [0001] The invention relates to the technical field of fluorescent probes for metal ion detection, in particular to a rhodamine-based Cu 2+ Fluorescent probes and methods for their preparation. Background technique [0002] Fluorescent probes can be used for detection and research in the fields of biology, chemistry, environment, food, etc. Currently, for Cu 2+ There are many reports on fluorescent probes for detection, but most of them lack practicability. The most critical problem is that the solvent applicability is not enough. Most applications need to be carried out in 100% aqueous solution, and most Cu 2+ Fluorescent probes need to work in a mixed solvent of organic solvents and water; secondly, the existing Cu 2+ The anti-interference of fluorescent probes is not enough, the existing Cu 2+ Fluorescent probes, except for Cu under certain conditions 2+ In addition to having a selective response, it often also responds to Hg 2+ Wait for other metal i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/06C07D491/107G01N21/64
CPCC09B11/24C09K11/06
Inventor 不公告发明人
Owner KUNSHAN DONGDA ZHIHUI TECH CONSULTANT
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