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Lutein ester nano particle and preparation method thereof

A technology of lutein esters and nanoparticles, which is applied in the field of medicines and health care products to achieve the effects of expanding the application range, increasing stability, and increasing water solubility

Active Publication Date: 2014-10-15
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there are few literatures on making lutein esters water-soluble, and there are no reports on making lutein esters into nanoparticles

Method used

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  • Lutein ester nano particle and preparation method thereof
  • Lutein ester nano particle and preparation method thereof
  • Lutein ester nano particle and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Lutein ester (containing lutein 140g / kg) 4g

[0031] Sodium hydroxymethylcellulose 8g

[0032] Tween 80 4g

[0033] Add 8g sodium hydroxymethyl cellulose and 400mL acetone into a 500mL three-necked flask, heat it in an oil bath at 50°C to dissolve it; add 4g lutein ester and 200mL acetone into a 500mL eggplant-shaped bottle, heat it in an oil bath at 50°C It dissolves; under mechanical stirring (100rpm), slowly add the lutein ester solution into the sodium hydroxymethyl cellulose solution, then add 4g Tween 80, continue heating at 50°C; evaporate the solvent under reduced pressure, vacuum dry, embrittle Then crushed into powder.

[0034] Example 2

Embodiment 2

[0036] Lutein ester (containing lutein 155g / kg) 2g

[0037] Macrogol 4000 100g

[0038] Span 80 20g

[0039] Add 100g of polyethylene glycol 4000 and 500mL of absolute ethanol into a 1000mL three-neck flask, heat it in an oil bath at 60°C to dissolve it; add 2g of lutein ester and 50mL of absolute ethanol into a 100mL eggplant-shaped bottle, Heat it in the bath to dissolve; slowly add the lutein ester solution to the polyethylene glycol 4000 solution under mechanical stirring (1000rpm), then add 20g Span 80, continue heating at 60°C; evaporate the solvent under reduced pressure, and spray dry Made into powder.

[0040] Example 3

Embodiment 3

[0042] Lutein ester (containing lutein 180g / kg) 2g

[0043] Galactose 5g

[0044] Povidone K30 5g

[0045] Tween 40 4g

[0046] Add 5g of galactose, 5g of povidone K30 and 250mL of absolute ethanol into a 500mL three-neck flask, heat in an oil bath at 70°C to dissolve; add 2g of lutein ester and 100mL of absolute ethanol into a 250mL eggplant-shaped flask, Heat in an oil bath at 50°C to dissolve; slowly add the lutein ester solution to the galactose and povidone K30 solution under mechanical stirring (3000rpm), then add 4g Tween 40, continue heating at 70°C; evaporate under reduced pressure Solvent, dried in vacuum, crushed into powder after embrittlement.

[0047] Example 4

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Abstract

The present invention relates to lutein ester nano particles and a preparation method thereof. A prescription for the lutein ester nano particles provided by the invention comprises lutein ester, a wrapping material and an emulsifier in a weight ratio of 1:2-50:2-20 and the optimal ratio of 1:5-20:2-5. The method comprises the steps of: 1, dissolving the wrapping material in an organic solvent under heating conditions; 2, mixing the lutein ester with the same organic solvent, and heating to dissolve; 3, adding the lutein ester solution in batch with mechanical stirring to a wrapping material solution and adding the emulsifier to make the solution particles reach nanometer level; and 4, volatilizing the solvent in the solution by a conventional method, and drying to obtain a powder. According to the invention, lutein ester is prepared into nano particles to dissolve in cold water or water at room temperature, and the stability of lutein ester is enhanced, thereby widening the scope of application, and facilitating transportation and storage.

Description

technical field [0001] The invention belongs to the field of medicines and health care products, and relates to a lutein ester nano-particle with stable properties and wide application and a preparation method thereof. Background technique [0002] Lutein esters are important carotenoid fatty acid esters. It is widely found in marigolds, pumpkins, cabbage, alfalfa and other plants. As early as 1994, the U.S. Food and Drug Administration (USA.FDA) recommended lutein esters as "eye health supplements" ("Supports eye health"). It is a safe, reliable, non-toxic and harmless food coloring that can improve human health. It can be widely used in meat products, fish products, various cans, drinks, fruit juices, pasta, cakes and advanced cosmetics (such as rouge, lipstick, etc.) , nail polish), etc., can also be used in medicine, feed and other fields. In recent decades, lutein esters have been continuously researched due to their wider application in human and animal consumption....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K36/28A61K31/047A61P3/02A23L2/52A23L1/30A23C9/152
Inventor 韩静赵长东程惠
Owner SHENYANG PHARMA UNIVERSITY