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Topical skin preparation and healthy skin cell activation agent

A technology for skin external preparations and normal skin, applied in skin care preparations, skin diseases, cosmetics, etc., can solve problems such as no effective research, and achieve excellent effects over time

Inactive Publication Date: 2014-10-22
FUJIFILM CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, no detailed studies on the effects in cells other than

Method used

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  • Topical skin preparation and healthy skin cell activation agent
  • Topical skin preparation and healthy skin cell activation agent
  • Topical skin preparation and healthy skin cell activation agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-1～1-4

[0151] [Examples 1-1 to 1-4, Comparative Examples A-1 to A-2, B-1 to B-2]

[0152] In Examples 1-1 to 1-4, Comparative Examples A-1 to A-2, and B-1 to B-2, the total content of lycopene and astaxanthin contained in the present invention and the individual It was confirmed that when these were used, a superior cell activation effect was obtained.

[0153] The samples used in Examples 1 to 4 were samples in which the contents of lycopene and astaxanthin were within the range of the total contents of these components in the present invention. On the other hand, in the samples used in Comparative Examples A-1 to A-2 and B-1 to B-2, the contents of lycopene and astaxanthin were within the range of the total contents of these components in the present invention. external samples.

[0154]

[0155] The HaCaT cell line (human epidermal keratinocyte line, purchased from DKFZ, Germany, the same below) was seeded into a 96-well plate using DMEM medium supplemented with 10v / v% FBS, at...

Embodiment 2-1～2-8、 comparative example 2-1

[0171]

[0172] Astaxanthin dispersions and lycopene dispersions used in the respective skin external preparations of Examples and Comparative Examples were prepared as follows.

[0173] "Preparation of Astaxanthin Dispersion A"

[0174] The following components were melt|dissolved for 1 hour, heating at 70 degreeC, and the aqueous phase composition A was obtained.

[0175]

[0176] The following components were melt|dissolved for 1 hour, heating at 70 degreeC, and the oil phase composition A was obtained.

[0177]

[0178] The aqueous phase composition A obtained above was directly stirred (10,000 rpm) with a homogenizer (model name: HP93, manufactured by SMT CORPORATION) while maintaining 70°C, and the oil phase composition was added to the aqueous phase composition A. Material A, to obtain a predispersion. Next, the obtained predispersion was cooled to about 40° C., and high-pressure emulsification was performed at a pressure of 200 MPa using Altimizer HJP-25005 (ma...

Embodiment 2-9

[0224] An emulsion (100% by mass in total) having the following composition was prepared.

[0225]

[0226]

[0227] The content of lycopene was 0.0002% by mass, the content of astaxanthin was 0.003% by mass, and the content of tocopherols was 0.026% by mass relative to the total mass of the emulsion having the above composition.

[0228] The mass ratio of lycopene to astaxanthin and the mass ratio of tocopherols to lycopene and astaxanthin are as follows.

[0229] Lycopene / Astaxanthin=0.67

[0230] Tocopherols / (lycopene + astaxanthin) = 8.1

[0231] (The term "tocopherols" is a general term for tocopherols and derivatives thereof.)

[0232] In addition, it was confirmed that in the above composition, when fucoxanthin was used instead of lutein, an emulsion could be prepared in the same manner.

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Abstract

A topical skin preparation and healthy skin cell activation agent, containing lycopene and astaxanthin, the total amount of lycopene and astaxanthin contained being in the range of 0.00001-0.2 mass%.

Description

technical field [0001] The present invention relates to an external preparation for skin and an agent for activating normal skin cells. Background technique [0002] Carotenoids are known to have various physiological activities. For example, Mol. Cancer Ther., 2005, Vol.4(1), pp177-186 discloses the relationship between certain cancers and carotenoids. In addition, Japanese Patent Application Publication No. 2009-511570 discloses that lycopene or a derivative thereof inhibits the proliferation of breast cancer cells or prostate cancer cells. However, no detailed studies on the effect in cells other than it have been performed. [0003] In addition, in the field of cosmetics, cosmetics containing lycopene, which is a kind of carotenoid, are known. It is described that by adding lycopene to cosmetics, effects such as anti-oxidation and active oxygen removal can be obtained (for example, JP-A-2000-229827 and JP-A-2002-128651). [0004] In addition, primrose, lycopodium, an...

Claims

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Application Information

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IPC IPC(8): A61K8/31A61K8/35A61K8/37A61K8/55A61K8/60A61K8/67A61K31/01A61K31/122A61K47/24A61K47/26A61K47/34A61K47/36A61P17/00A61P43/00A61Q1/14A61Q19/00A61Q19/08A61Q19/10
CPCA61K31/01A61Q19/00A61K8/35A61K8/31A61Q19/08A61K31/122A61P17/00A61P43/00A61K2300/00A61K8/37A61K9/10A61K47/10
Inventor 乾江梨子金泽克彦
Owner FUJIFILM CORP
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