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Ceramide dispersion, and process for producing same

A technology of ceramide and manufacturing method, which is applied in the direction of amide active ingredients, chemical instruments and methods, and medical preparations of non-active ingredients, etc., which can solve the problem of compromising safety, usability, inability to make ceramide transparent and soluble, and difficulty in ensuring overtime Stability and other issues

Inactive Publication Date: 2011-10-12
FUJIFILM CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in order to make ceramide transparent and soluble, it is necessary to mix a large amount of surfactant, which may impair safety and usability.
On the other hand, when the amount of the surfactant is reduced in order to obtain excellent usability, it often forms a cloudy or translucent milky state, and the ceramide cannot be made transparent and soluble. However, separation or creaming occurs, and it may be difficult to secure sufficient stability over time.
[0008] As described above, the present situation is that, even with these technologies, it is not possible to obtain a ceramide dispersion capable of stably dispersing ceramide and having excellent stability over time.

Method used

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  • Ceramide dispersion, and process for producing same
  • Ceramide dispersion, and process for producing same
  • Ceramide dispersion, and process for producing same

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0244] When the micro-mixer is used in the preparation of small particle size emulsion as one of the microchemical processes, due to the low energy and low heat generation, compared with the usual stirring emulsification dispersion method and high-pressure homogenizer emulsification dispersion, it is easy to obtain uniform particle size , A good emulsion or dispersant with excellent storage stability. It is the best method for emulsification containing natural ingredients that are easily deteriorated by heat.

[0245] The outline of the method of emulsifying or dispersing using a micro mixer is to divide the water phase and the oil phase into minute spaces, and to make the respective minute spaces contact or collide with each other. This is obviously different from the membrane emulsification method and the fine channel emulsification method, which are methods in which only one is divided into a small space and the other is bulk. Effect. There are devices of various structur...

Embodiment 1

[0300] The components described in the following oil phase liquid 1 were stirred at room temperature for about 30 minutes to prepare oil phase liquid 1. In addition, for the following aqueous phase liquid 1, add inulin lauryl carbamate (INUTEC SP1: manufactured by SIBER HEGNER, Japan; the same below) to pure water, heat to about 50°C, and stir well to dissolve it. The remaining ingredients were added and mixed, and the temperature of the liquid was adjusted to 30°C.

[0301]

[0302]

[0303]

[0304]

[0305]

[0306] (pH=7.4 of the final ceramide dispersion)

[0307] The obtained oil phase liquid 1 (oil phase) and water (water phase) were micromixed (dispersed) with a collision type KM micromixer 100 / 100 at a ratio (mass ratio) of 1:7 to obtain ceramide Dispersion 1. In addition, the usage conditions of the micromixer are as follows.

[0308] -Microchannel-

[0309] oil side microchannel

[0310] Section shape / width / depth / length=rectangular / 70μm / 100μm / 10mm ...

Embodiment 2

[0317] The oil phase liquid 1 and the water phase liquid 1 in Example 1 were changed to the following oil phase liquid 2 and the water phase liquid 2, and mixed in the same manner as in Example 1, and the liquid temperature was adjusted to 28°C, Micromixing was carried out in the same manner as in Example 1 to obtain a ceramide dispersion 2. Then, 90 parts of the obtained ceramide dispersion liquid 2 and 10 parts of 1,3-butanediol were added, mixed and stirred well, and then concentrated, and concentrated in the same manner as in Example 1 to obtain a ceramide dispersion B. .

[0318]

[0319]

[0320]

[0321]

[0322] (pH=7.7 of final ceramide dispersion)

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Abstract

Disclosed is a ceramide dispersion which comprises (1) ceramide-containing particles which contain a ceramide component, are dispersed as an oily phase component in an aqueous phase, and have a volume average particle diameter of 1 to 100 nm inclusive, (2) a fatty acid component comprising either a fatty acid and / or a fatty acid salt, (3) a polyhydric alcohol which is contained in the ceramic dispersion in an amount 5 to 20 times larger than the amount of the ceramide component, and (4) a polysaccharide fatty acid ester. The ceramide dispersion has a pH value of 6 to 8 inclusive.

Description

technical field [0001] The invention relates to a ceramide dispersion and a manufacturing method thereof. Background technique [0002] Ceramides exist in the stratum corneum of the skin and play an important role in building a lipid barrier necessary for moisture retention and maintaining moisture. Ceramides located in the stratum corneum are substances produced by decomposing cerebrosides with an enzyme called cerebrosidase. It is known that a part of ceramide is converted into phytosphingosine and sphingosine by an enzyme called ceramidase, and is important as a regulator of cell proliferation and differentiation. There are 6 different types of ceramides in human skin, and they have different functions. [0003] However, since ceramides are highly crystalline substances, have low solubility in other oils, and crystallize at low temperatures, it is difficult to secure stability when blending them into cosmetics. In addition, although the aqueous ceramide dispersion can ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01J13/00A61K8/04A61K8/34A61K8/36A61K8/37A61K8/65A61K8/68A61K8/73A61K9/10A61K31/164A61K47/10A61K47/12A61K47/14A61K47/36A61Q19/00C09K23/34C09K23/38C09K23/56
CPCA61K8/06A61K8/062A61K8/345A61K8/361A61K8/68A61K8/85A61K31/164A61K2800/21A61Q19/00A61K8/04A61K8/73B01J13/00B01J13/02
Inventor 芹泽慎一郎森久容荒河纯
Owner FUJIFILM CORP
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