High-content vitamin C and vitamin E stable system compound preparation and preparation method thereof

A stable system and compound preparation technology, applied in the fields of personal care products, chemical industry, and medicine, can solve problems such as limiting the effect of antioxidants, achieve the effects of improving transdermal absorption efficiency and skin feel, improving absorption efficiency, and improving stability

Active Publication Date: 2014-10-29
YUNNAN BOTANEE BIO TECH GRP CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Vitamin C due to its water-soluble properties and instability in aqueous systems, and vitamin E due to its oil-soluble

Method used

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  • High-content vitamin C and vitamin E stable system compound preparation and preparation method thereof
  • High-content vitamin C and vitamin E stable system compound preparation and preparation method thereof
  • High-content vitamin C and vitamin E stable system compound preparation and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0037] The preparation method of the high-content vitamin CE compound stable system compound preparation of the present embodiment comprises the following steps:

[0038] A. Mix 0.1kg vitamin E and 0.25kg PEG-40 hydrogenated castor oil in a stainless steel container in advance to prepare the vitamin E mixture for subsequent use;

[0039] B. Put 0.6kg of butyrolactone, 1.6kg of ethoxydiethylene glycol and 1.60kg of N-methylpyrrolidone into the configuration pot, turn on the stirring, set the speed at 50 rpm, then slowly add 1.0kg of vitamin C, and put in After completion, stir for 30 minutes until the system is a clear liquid to obtain a vitamin C mixture;

[0040]C. drop into 1.0kg glycerin, 2.6kg butanediol, 1.0kg propylene glycol and 0.25kg polyethylene glycol-8 in the vitamin C mixed solution that step B makes again, stir 20 minutes to mix;

[0041] D. Set the stirring speed to 35 rev / min, then slowly drop in the vitamin prepared in step A while stirring.

[0042] Among t...

Embodiment 2

[0044] The preparation method of the present embodiment comprises the following steps:

[0045] A. Mix the weighed 0.12kg vitamin E and 0.3kg PEG-40 hydrogenated castor oil in a stainless steel container in advance to prepare the vitamin E mixture for subsequent use;

[0046] B. Put the weighed 0.72kg of butyrolactone, 1.92kg of ethoxydiethylene glycol and 1.92kg of N-methylpyrrolidone into the configuration pot, turn on the stirring, set the speed at 50 rpm, and then slowly add the weighed 1.2kg of vitamin C, after putting in completely, stir for 40 minutes until the system is a clear liquid to obtain a vitamin C mixture;

[0047] C. drop into 0.8kg glycerol, 1.92kg butylene glycol, 0.8kg propylene glycol and 0.3kg polyethylene glycol-8 in the vitamin C mixed solution that step B makes again, stir 20 minutes to mix;

[0048] D. Set the stirring speed to 35 rpm, then slowly add the vitamin E mixture prepared in step A while stirring, stir for 10 minutes until the system is a ...

Embodiment 3

[0050] The preparation method of the present embodiment comprises the following steps:

[0051] A. Mix the weighed 0.15kg vitamin E and 0.375kg PEG-40 hydrogenated castor oil in a stainless steel container in advance to prepare the vitamin E mixture for subsequent use;

[0052] B. Put 0.9kg of butyrolactone, 2.4kg of ethoxydiethylene glycol, and 2.4kg of N-methylpyrrolidone into the configuration pot, turn on the stirring, set the speed at 50 rpm, and then slowly add the weighed 1.5kg of vitamin C, after the input is complete, stir for 50 minutes until the system is a clear liquid, to obtain a vitamin C mixture;

[0053] C. drop into 0.6kg glycerin, 0.7kg glycol, 0.6kg propylene glycol and 0.375kg polyethylene glycol-8 in the vitamin C mixed solution that step B makes again, stir 20 minutes to mix;

[0054] D. Set the stirring speed to 35 rpm, then slowly add the vitamin E mixture prepared in step A while stirring, stir for 10 minutes until the system is a clear liquid, and t...

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Abstract

The invention discloses a high-content vitamin C and vitamin E stable system compound preparation. The high-content vitamin C and vitamin E stable system compound preparation comprises the following components in percentage by weight: 10.0-15.0 percent of vitamin C, 1.0-1.5 percent of vitamin E, 6.00-9.0 percent of butyrolactone, 10.0-24.0 percent of ethoxy diethylene glycol, 7.0-26.0 percent of butanediol, 2.5-3.75 percent of PEG-40 hydrogenated castor oil, 6.0-10.0 percent of propylene glycol, 2.5-3.75 percent of polyethylene glycol-8, 6.0-10.0 percent of glycerinum and 16.0-24.0 percent of N-methyl pyrrolidone. The invention also provides a preparation method of the compound preparation. Through an anhydrous system, the contact between vitamin C and vitamin E and oxygen and heavy metals is greatly reduced, vitamin E is protected by virtue of vitamin C, and in reverse, vitamin E can coordinately protect vitamin C; therefore, the compound preparation is good in skin touch and easy to absorb, can be widely applied to the fields of medicines, medical care products, and personal care products which have functions of whitening, skin brightening, antioxidation, line reduction, anti-aging and the like.

Description

technical field [0001] The invention belongs to the fields of medicine, chemical industry and personal care products, and relates to a high-content vitamin CE stable system compound preparation and a preparation method thereof. Background technique [0002] Vitamin C and vitamin E are the most well-known natural antioxidants. One is water-soluble and the other is oil-soluble. They are widely derived from foods such as fruits, vegetables and meat. Since its discovery, countless studies at home and abroad have confirmed that it not only plays an important role as a powerful antioxidant for external and internal use in the fields of medicine and food, but also can be widely used as a powerful antioxidant in the fields of functional skin care products and cosmetics. But its stability has been the focus of domestic and foreign researchers. [0003] As we all know, vitamin C is difficult to maintain stability. Chemically speaking, vitamin C is a monovalent hydrophilic hydroxyl co...

Claims

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Application Information

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IPC IPC(8): A61K8/67A61K8/92A61K8/06A61K31/375A61K9/107A61K47/44A61Q19/08A61Q19/02A61P39/06A61P17/18A61K31/355
Inventor 李冰马骁苏温柔何黎
Owner YUNNAN BOTANEE BIO TECH GRP CO LTD
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