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Panaxoside composition as well as preparation method and application thereof

A technology of ginsenoside and composition, applied in the field of ginsenoside composition, can solve the problems of inaccurate clinical curative effect, recurrence of tumor patients, and unsatisfactory clinical application, and achieve significant direct inhibition and killing of tumors, definite clinical curative effect, and satisfying clinical requirements. The desired effect of the application

Inactive Publication Date: 2014-10-29
祁展楷
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no effective way to solve the above problems. The usual way is to stop chemotherapy, or switch to other drugs, or use traditional Chinese medicine for adjuvant therapy. However, the above methods have inaccurate clinical curative effects and lead to a large number of cancer patients relapse. Defects, unable to meet the needs of clinical application

Method used

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  • Panaxoside composition as well as preparation method and application thereof
  • Panaxoside composition as well as preparation method and application thereof
  • Panaxoside composition as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] The preparation method of ginsenoside composition:

[0062] First, 10g of the total saponin composition obtained from ginseng stems and leaves is dissolved in a solution composed of 15g of alkali metal hydroxide and high-boiling point fatty alcohol compounds, and heated under a pressure of 2mp for hydrolysis. The hydrolysis temperature is 240°C. The reaction time is 4 hours, the reaction product is cooled to room temperature, diluted with water to 6 times the original volume, added to a macroporous resin for adsorption, eluted, and the eluate is collected to obtain the product of the present invention.

[0063] The macroporous resin is the product of AB-8 chemical plant of Tianjin Nankai University.

[0064] In the solution that alkali metal hydroxide and high-boiling fatty alcohol compound form, the weight concentration of alkali metal hydroxide is 15%;

[0065] The high-boiling fatty alcohol compound is glycerol;

[0066] Described alkali metal hydroxide is NaOH;

...

Embodiment 2

[0070] The preparation method of ginsenoside composition:

[0071] First, 10g of the total saponin composition obtained from ginseng stems and leaves is dissolved in a solution composed of 20g of alkali metal hydroxide and high-boiling fatty alcohol compounds, and heated under a pressure of 1.5mp for hydrolysis. The hydrolysis temperature is 230°C , The reaction time is 6 hours, the reaction product is cooled to room temperature, diluted with water to 8 times the original volume, added to the macroporous resin for adsorption, eluted, and the eluate is collected to obtain the product of the present invention. The macroporous resin is the SA-2 product of Tianjin Orui Biotechnology Co., Ltd.

[0072] In the solution that alkali metal hydroxide and high-boiling fatty alcohol compound form, the weight concentration of alkali metal hydroxide is 20%;

[0073] The high-boiling fatty alcohol compound is glycerol;

[0074] The alkali metal hydroxide is KOH;

[0075] After comparing t...

Embodiment 3

[0080] Experimental Study on the Killing and Inhibitory Effects of Ginsenoside Composition Sensitizing Chemotherapeutic Drugs on Tumor

[0081] Materials and Methods

[0082] 1. Experimental animals and tumor models

[0083] C57 mice bearing Lewis lung cancer, B16 melanoma, and EL-4 lymphoma (provided by ATCC) were used in the experiment, 90 male and female mice in total, weighing 20±2 grams.

[0084] 2. Grouping of animals

[0085] Transplant the tumor into the forelimb of the mouse according to the conventional experimental techniques, and wait for the tumor to grow to 200~400mm 3 Afterwards, they were divided into groups at random, and the experiment was divided into a blank control group, a chemotherapy group alone, and a chemotherapy plus ginsenoside composition group, with 10 animals in each group.

[0086] 3. Drugs and dosage

[0087] A. Ginsenoside composition

[0088] The product of Example 1 was used, prepared as an injection when used, with a concentration of ...

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Abstract

The invention discloses a panaxoside composition as well as a preparation method and application thereof. The panaxoside composition comprises the following components in percentage by weight: 10-80 percent of 20(S)-protopanoxadiol, 1-20 percent of 25-alkene-20(S)-protopanoxadiol, 5-50 percent of 20(S) and 24(R)-panaxatriol epoxy compounds, 5-50 percent of 20(S)-panaxatriol, 1-20 percent of 20(S)-24-methyl-23-alkene-24-carbonyl-protopanoxadiol and 1-20 percent of 25-hydroxy-23-alkene-20(S)-protopanoxadiol. The panaxoside composition disclosed by the invention has the beneficial effects that the panaxoside composition has remarkable treatment effects of directly inhibiting and killing cancers, reversing the multidrug resistance of cancer cells and enhancing the treatment effects of a cancer chemotherapeutic medicine, is definite in clinical effect and capable of preventing the defects that no other treatment methods are available after drug discontinuance and drug-resisting relapse because lots of cancer patients cannot tolerate the toxicity of the chemotherapeutic medicine, and meeting the needs of clinical application.

Description

technical field [0001] The invention relates to a ginsenoside composition and its preparation method and application. Background technique [0002] Tumor is a disease that is extremely harmful to human beings. [0003] In the process of treating tumors with chemotherapy, there are problems that tumor patients cannot tolerate the toxicity of chemotherapy drugs and the drug resistance and recurrence of cancer cells. Among them, how to reverse the problem of tumor multidrug resistance, how to sensitize tumor chemotherapy drugs to The problem of inhibition and killing of tumor cells and the problem of developing low-toxic or non-toxic anti-tumor drugs are difficult problems in the treatment of tumors. [0004] At present, there is no effective way to solve the above problems. The usual way is to stop chemotherapy, or switch to other drugs, or use traditional Chinese medicine for adjuvant therapy. However, the above methods have inaccurate clinical curative effects and lead to a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/58A61P35/00A61K31/575
Inventor 祁展楷
Owner 祁展楷
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