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Baicalein production method

A production method and technology for baicalein are applied in the production field of baicalein, can solve the problems of low collection ratio of baicalin, rough process, waste and the like, and achieve the effects of improving collection rate, high collection rate, and optimizing process parameters.

Inactive Publication Date: 2014-11-05
施佩蓓
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the rough process of the current baicalin production method, the collection ratio of baicalin is low, resulting in a large amount of waste

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The invention provides a kind of production method of baicalein, it is characterized in that, comprises the steps:

[0016] S1. Take 150g of Scutellaria baicalensis coarse powder, add 1.2kg of water at 90°C, and let stand for 20min;

[0017] S2. Filter with cotton, add 700 g of the residue to 90°C water, let stand for 20 minutes, and combine the filtrates;

[0018] S3. Add hydrochloric acid to adjust the pH value to 2, heat the acidic water solution in a water bath to 80°C, and let it stand for 30 minutes. When the supernatant liquid is clear, pour the supernatant liquid into another container, and rinse the lower sediment with 80°C water , to obtain crude total flavonoids;

[0019] S4. Put the crude total flavonoids in the Erlenmeyer flask, add ethanol to soak for several times, until the color of the ethanol infusion becomes lighter, and then add acetone to precipitate the resinous residue;

[0020] S5, reclaim the ethanol soaking solution and the acetone soaking so...

Embodiment 2

[0026] A kind of production method of baicalein, is characterized in that, comprises the steps:

[0027] S1. Take 150g of Scutellaria baicalensis root powder, add 1.2kg of water at 95°C, and let it stand for 20 minutes;

[0028] S2. Filter with cotton, add 700 g of the residue to 95°C water, let stand for 20 minutes, and combine the filtrates;

[0029] S3. Add hydrochloric acid to adjust the pH value to 2, heat the acidic water solution in a water bath to 80°C, and let it stand for 30 minutes. When the supernatant liquid is clear, pour the supernatant liquid into another container, and rinse the lower sediment with 80°C water , to obtain crude total flavonoids;

[0030] S4. Put the crude total flavonoids in the Erlenmeyer flask, add ethanol to soak for several times, until the color of the ethanol infusion becomes lighter, and then add acetone to precipitate the resinous residue;

[0031] S5, reclaim the ethanol soaking solution and the acetone soaking solution respectively,...

Embodiment 3

[0037] The invention provides a kind of production method of baicalein, it is characterized in that, comprises the steps:

[0038] S1. Take 150 g of Scutellaria baicalensis root powder, add 1.2 kg of water at 100°C, and let stand for 20 minutes;

[0039] S2. Filter with cotton, add 700 g of the residue to 100°C water, let stand for 20 minutes, and combine the filtrates;

[0040] S3. Add hydrochloric acid to adjust the pH value to 2, heat the acidic water solution in a water bath to 80°C, and let it stand for 30 minutes. When the supernatant liquid is clear, pour the supernatant liquid into another container, and rinse the lower sediment with 80°C water , to obtain crude total flavonoids;

[0041] S4. Put the crude total flavonoids in the Erlenmeyer flask, add ethanol to soak for several times, until the color of the ethanol infusion becomes lighter, and then add acetone to precipitate the resinous residue;

[0042] S5, reclaim the ethanol soaking solution and the acetone soa...

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PUM

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Abstract

The invention provides a baicalein production method which comprises the following steps: S1, taking 150g of scutellaria root crude powder, adding into 1.2kg of 90-100 DEG C water, and placing for 20min; S2, filtering, adding residues into 700g of 90 to 100 DEG C water, placing for 20min, and merging filtrate; S3, adding hydrochloric acid to regulate pH value to 2, heating to 80 DEG C with water bath, placing for 30min, using 80 DEG C water for flushing lower layer sediment to obtain coarse total flavonoids; S4, adding the coarse total flavonoids into ethanol, adding acetone for cleaning to obtain a resinous residue; S5, respectively recovering an ethanol soaking solution and an acetone soaking liquid to obtain ethanol and acetone insoluble substances as crude baicalin products; S6, adding the crude baicalin products into the ethanol for water bath for 30min, filtering, adding into methanol, crystallizing, filtering, and drying to obtain baicalin, taking the baicalin, adding into the ethanol, placing the extracting solution for placing for crystallization, and filtering crystal to obtain a crude baicalein product; S8, adding the crude baicalein product into chloroform for extraction, merging chloroform extracts, placing for crystallization, filtering crystal, and adding acetone for recrystallization for 2-4 times to obtain baicalein. The baicalein collection rate is high.

Description

technical field [0001] The invention relates to a production method of baicalein, in particular to a production method of baicalein by utilizing the root powder of baicalein root. Background technique [0002] Baicalein synonym: baicalein, extraction source: Lamiaceae plant Scutellaria altissima L. leaves; S. Scrodiifolia Fisch. (S.galericulata L.) leaves and roots; Bignoniaceae plant wood butterfly Seeds and stem bark of Oroxylumindicum (L.) Vent.; leaves of PlantagomajorL. Properties: Yellow needle-like crystal (from ethanol) Melting point: 264°C-265°C Solubility: Soluble in methanol, ethanol, acetone, ethyl acetate and hot glacial acetic acid, slightly soluble in chloroform, soluble in dilute sodium hydroxide and turns green Brown, but unstable, easily oxidized to green. Molecular formula: C15H10O5, molecular weight: 270.24. Pharmacological effects: Baicalein has the functions of reducing cerebrovascular resistance, improving cerebral blood circulation, increasing cere...

Claims

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Application Information

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IPC IPC(8): C07D311/30C07D311/40
CPCC07D311/30C07D311/40
Inventor 施佩蓓
Owner 施佩蓓
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