A degradable spherical artificial bladder

An artificial bladder and artificial technology, applied in the direction of human tubular structure devices, can solve the problems of bladder tissue indistinguishability, and achieve the effect of convenient suture operation, reasonable structural design, and favorable adhesion and growth

Active Publication Date: 2016-05-18
杭州祥实生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Postoperative histological examination found that three layers of normal bladder tissue (epithelial, muscular layer, serosal layer) could be seen at the patch, and it was indistinguishable from normal bladder tissue

Method used

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  • A degradable spherical artificial bladder
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Experimental program
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Embodiment 1

[0012] see figure 1 , figure 2 , the object of the present invention is to provide a degradable spherical artificial bladder, which is a medical in situ implantable degradable spherical artificial bladder lined with small intestinal submucosa, which consists of an artificial ureteral loop 1, an artificial bladder body 2, an artificial urethral loop 3. The submucosa of the small intestine is composed of 4, the artificial ureteral loop 1 is a mesh pipe structure with a diameter of 0.6-0.8cm, the artificial urethral loop 3 is a mesh pipe structure with a diameter of 0.8-1.0cm, and the artificial bladder body 2 is a mesh spherical structure. The capacity is 200~300ml. The artificial urethral loop 3 is connected to the artificial ureteral loop 1 and the artificial bladder body 2 respectively. The three are integrally formed. The small intestinal submucosa 4 is lined inside the artificial ureteral loop 1, the artificial bladder body 2 and the artificial urethral loop 3. .

[0013...

Embodiment 2

[0015] The implantation method of the present invention is as follows: under general anesthesia or epidural anesthesia, perform total cystectomy on the patient, after hemostasis is complete, insert the artificial bladder of the present invention in the pelvic cavity in situ, after adjusting the appropriate position, clinically One end of the commonly used 5Fr ureteral stent is placed into the artificial ureteral loop 1, and the other end is placed into the autologous ureteral stump, and then the artificial ureteral loop 1 is anastomosed with the autologous ureteral stump. At this time, attention should be paid to suturing the normal ureteral mucosa to the SIS layer of the artificial ureter as much as possible. First, the autologous ureteral stump can be properly everted, and the autologous ureteral mucosa and the SIS layer of the artificial urinary catheter can be sutured intermittently with absorbable sutures, and then the outer frame and the ureteral serosa layer can be suture...

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Abstract

The present invention provides a degradable spherical artificial bladder, which is a medical in situ implantable degradable spherical artificial bladder lined with small intestinal submucosa. The artificial ureteral loop and the artificial urethral loop are reticular pipe structures, and the artificial bladder body is a reticulated spherical structure. The artificial urethral loop, the artificial ureteral loop, and the artificial bladder body are integrally formed, and the small intestinal submucosa is lined inside the three. The invention has a reasonable structural design and fully utilizes the advantages of natural-artificial composite materials. The mesh outer support plays a role of mechanical support in the early stage of implantation, facilitates the suture operation of the surgical port, and can maintain the structure of the urinary bladder for temporary urine storage. functions as well as facilitate fixation to pelvic tissues. The invention is applied in cystectomy operation to replace the resected diseased bladder, and finally form an organ similar to the autologous bladder.

Description

technical field [0001] The invention belongs to medical artificial organs, in particular to a degradable spherical artificial bladder, which is suitable for bladder tumors, necrotizing and interstitial cystitis, tuberculous bladder contracture and congenital deformities and other patients who need urinary diversion and bladder reconstruction . Background technique [0002] At present, after total cystectomy for advanced bladder cancer, urinary diversion is necessary, that is, an artificial bladder is used to replace the function of the original bladder. The existing clinical method is to use the patient's own intestinal segment to make a urinary bladder with a capacity of about 300-500ml—artificial bladder, but this method not only destroys the normal structure and function of the patient's digestive tract, but also destroys the intestinal segment structure. It is far from the bladder structure, so there may be many postoperative complications such as intestinal obstruction...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/04
Inventor 张大宏王帅
Owner 杭州祥实生物科技有限公司
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