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A kind of Poria polysaccharide injection and preparation method thereof

A technology of tuckahoe polysaccharide and carboxymethyl tuckahoe polysaccharide is applied in the directions of pharmaceutical formulation, drug delivery, digestive system, etc., which can solve problems such as limitations and achieve the effects of safe and reliable use and good drug absorption.

Active Publication Date: 2017-03-29
LONGYAN UNIV
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  • Abstract
  • Description
  • Claims
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Problems solved by technology

Practice has shown that the activity of Poria cocos polysaccharide will be limited due to oral administration, while injection Poria cocos polysaccharide can directly enter the human body through intravenous injection or intraperitoneal injection to directly play a medicinal role, which is incomparable to the oral drug effect.

Method used

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preparation example Construction

[0029] The present invention relates to a kind of preparation method of Poria cocos polysaccharide injection, described method step is as follows:

[0030] Step 1, the extraction and purification of carboxymethylpachyran:

[0031] A. Reflux the poria cocos powder dried at 60-100°C to constant weight in a Soxhlet extractor for 4-6 hours, remove the esters, and take the dregs. The reflux extraction solvent is ethyl acetate, and reflux extraction 2-3 times ;

[0032] B. The obtained dregs are refluxed and extracted in a boiling water bath in a reflux device for 4-6 hours, refluxed and extracted 2 to 3 times, and centrifuged to get the supernatant;

[0033] C. Concentrate the supernatant in a rotary evaporator to a water content of 10-15%, remove protein by Severge method, take the supernatant and add ethanol to precipitate polysaccharides, refrigerate at 0-4°C overnight, centrifuge at 3000-4000r / min for 10 -15min to take the precipitate, dry at low temperature to obtain water-s...

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Abstract

The invention provides a pachymaran injection and a preparation method thereof. The injection comprises carboxymethyl pachymaran, water for injection, benzyl alcohol and Tween 80. Each milliliter of the injection comprises 2 mg of carboxymethyl pachymaran; and 10 mL of benzyl alcohol and Tween 80 is added in every 2 g of carboxymethyl pachymaran. The method comprises the steps of extracting poria cocos powder by refluxing and removing impurities to obtain pachymaran; then adding an organic solvent for modification and purification to obtain a carboxymethyl pachymaran pure product; and finally adding the water for injection, benzyl alcohol and Tween 80, thus obtaining the pachymaran injection. The injection is suitable for intramuscular injection, is good in drug absorption, has no irritant reaction, and is safe and reliable for use.

Description

technical field [0001] The invention relates to a poria cocos polysaccharide injection and a preparation method thereof. Background technique [0002] Poria cocos (scientific name: Poria cocos (Schw.) Wolf.), the medicinal part is the sclerotia of Poria cocos, a fungus of Polyporaceae. It has diuresis and dampness expelling, invigorating the spleen, and calming the nerves. It can also be made into powder and used as a whitening mask for ladies. The ancients called Poria cocos "the magic medicine of the four seasons" because it has a wide range of effects, regardless of the seasons, and it can be combined with various medicines to exert its unique effects regardless of cold, temperature, wind, and dampness. Poria cocos is sweet, light, and flat in nature. When used as medicine, it has the functions of diuresis and dampness, spleen and stomach, and calming the mind. Modern medical research: Poria cocos can enhance the immune function of the body, and Poria cocos polysacchar...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/715A61P35/00A61P1/16C08B37/00
Inventor 林标声胡晓冰杨生玉陈小红朱德霞
Owner LONGYAN UNIV
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