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Improved method for preparing ginkgo extracts having a low content of 4'-o-methyl pyridoxine and/or biflavones

A technology of methyl pyridoxine and extract, which is used in food preparation, medical raw materials derived from Ginkgo biloba, drug combination and other directions

Inactive Publication Date: 2014-12-10
DR VILMAR SHVABE GMBKH EHND KO KG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, depending on constraints that may be established in the future and in view of the requirement to modify the extraction composition as little as possible, it may be desirable to remove only the biflavones or 4'-O-methylpyridoxine

Method used

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  • Improved method for preparing ginkgo extracts having a low content of 4'-o-methyl pyridoxine and/or biflavones
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Examples

Experimental program
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Effect test

example 1

[0066] Example 1: Ginkgo biloba extract with reduced content of 4'-O-methylpyridoxine

[0067] 1249 g of the extract solution obtained according to the above preparation method were adjusted with water until the ethanol content was about 40% (w / w) and applied to 50 ml (corresponding to 0.28 ml per gram of dry extract) of Amberlite IR-120 (strongly acidic ion exchanger ) (column: about 2×16.5 cm; flow rate: about 8 ml / min) (step I)), followed by washing with 200 ml of 50% ethanol (w / w). The resulting solution was concentrated on a rotary evaporator and dried in vacuo at 50° C. (step m)): 179.4 g.

[0068] As can be seen from the table below, a 4'-O-methylpyridoxine content of 0.4 ppm was achieved without substantially changing the content of components relevant to efficacy.

example 2

[0071] Example 2a): Ginkgo biloba extract with reduced content of biflavones

[0072] 500 g of the extract solution obtained according to the above preparation method was adjusted with water until the ethanol content was about 40% (w / w) and applied to 400 ml (corresponding to 5.7 ml per gram of dry extract) of Sepabeads SP-850 (adsorbent resin) ( Column: about 4×32 cm; flow rate: about 8 ml / min) (step 1)), followed by flushing with a total of about 2 l of 40% ethanol (w / w). 10% (259.3 g) of the resulting solution was concentrated on a rotary evaporator and freeze-dried (step m)): 6.92 g. The remaining 90% of the solution was used in Example 2b).

[0073] It can be seen from the table below that the content of biflavones less than 1 ppm was respectively achieved without substantially changing the content of components related to efficacy.

example 2

[0074] Example 2b): Ginkgo biloba extract with reduced content of 4'-O-methylpyridoxine and biflavones

[0075] 90% (2334.1 g) of the solution obtained in Example 2a) was applied to 25 ml (corresponding to 0.40 ml per gram of dry extract) Amberlite IR-120 (strongly acidic ion exchanger) (column: about 1.5×11 cm; Flow rate: about 10 ml / min) (step 1)), followed by rinsing with 100 ml 40% ethanol (w / w). The resulting solution was concentrated on a rotary evaporator and freeze-dried (step m)): 61.67 g.

[0076] It can be seen from the table below that the 4'-O-methylpyridoxine content of 0.4 ppm and the biflavone content of less than 1 ppm were respectively achieved without substantially changing the content of components related to efficacy.

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Abstract

The present invention relates to an improved multi-step method for preparing an extract from ginkgo biloba having a reduced content of 4'-O-methyl pyridoxine and / or biflavones, wherein the depletion is carried out by filtration over an adsorber resin and / or an ion exchanger and the substances to be removed are retained on the resin. The invention further relates to an extract from ginkgo biloba having a reduced content of 4'-O-methyl pyridoxine and / or biflavones, which is obtainable by the method according to the present invention, as well as to its use.

Description

technical field [0001] The present invention relates to an improved multi-step process for the preparation of extracts of Ginkgo biloba (ginkgo biloba) with reduced levels of 4'-O-methylpyridoxine and / or biflavones, wherein exclusion is achieved by means of adsorbent resins and / or ionic Exchanger filtration is achieved and the material to be removed remains on the resin. The present invention further relates to Ginkgo biloba extracts obtainable by the process of the present invention having a reduced content of 4'-O-methylpyridoxine and / or biflavones, and uses thereof. Background technique [0002] For decades, Ginkgo biloba extract has been used as a medicine. It is currently used in the treatment of various dementias and their symptoms as well as abdominal and peripheral circulatory disorders. Components associated with efficacy were terpene lactones (ginkgolides A, B and C and bilobalide) and flavonoid glycosides (quercetin, kaempferol and iso rhamnetin (isorhamnetin)....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/16A61P25/28A61P7/00A23L1/30
CPCA23L1/3004A61K36/16A23L33/11A61P25/00A61P25/28A61P7/00A61P9/00A61P9/02A61P9/08A61P9/10A61K31/445A61K31/353
Inventor 克莱门斯·埃德尔迈尔荷尔曼·休格伊哥·酷克福瑞德须·朗
Owner DR VILMAR SHVABE GMBKH EHND KO KG
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