Application of mulberry fruit extract in preparation of hypoglycaemic agent

A mulberry extract and mulberry technology, which are applied in the field of medicine, can solve problems such as no public report on the mulberry extract, and achieve the effects of improving medicinal value, abundant raw materials, and simple preparation method.

Inactive Publication Date: 2014-12-10
HENAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] With the development of people's food preference and medicinal value of mulberry, more and more researches have been done on mulberry, but so far there has been no public report on the use of mulberry extract in the preparation of hypoglycemic drugs

Method used

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Embodiment Construction

[0007] The specific embodiments of the present invention will be described in detail below in combination with specific conditions.

[0008] The application of a mulberry extract of the present invention in the preparation of a hypoglycemic medicine. The mulberry extract is obtained by taking dried mulberry medicinal materials and crushing them into coarse powder through a 20-mesh sieve, and adding 10 times the weight and 80% ethanol of the mass concentration each time Extract twice with a flash extractor, 5 minutes each time, filter, combine the extracts, concentrate under reduced pressure until there is no alcohol taste, and obtain a concentrated solution. Disperse the concentrated solution with distilled water to a dispersion equivalent to 0.2g / ml of crude drug ; The dispersion was passed through AB-8 type macroporous adsorption resin, first eluted with 4 times the column volume of distilled water, discarded the aqueous solution; followed by 2 times the column volume of 10% eth...

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Abstract

The invention relates to application of mulberry fruit extract in preparation of a hypoglycaemic agent and aims at effectively solving the problem of preparation of the hypoglycaemic agent, further developing a new medicine used for treating diabetes and realizing new application of the mulberry fruit extract in the preparation of the hypoglycaemic agent. The mulberry fruit extract is obtained by the following steps: taking dry mulberry fruit medicinal material, smashing into coarse powder, adding ethyl alcohol the weight of which is 10 times that of the powder for extracting twice, filtering, putting extracting solutions together, carrying out reduced pressure concentration until no alcohol taste exists, thus concentrate is obtained, adding distilled water into the concentrate, dispersing to obtain dispersion liquid; causing the dispersion liquid to pass through macropore adsorption resin, firstly eluting with distilled water, and discarding water; continuously eluting with ethyl alcohol with the mass concentration of 10%, and discarding eluate; then eluting with ethyl alcohol with the mass concentration of 80%, collecting ethyl alcohol eluate with the mass concentration of 80%, carrying out pressure reduction for recycling ethyl alcohol, drying, and smashing, so that the mulberry fruit extract is obtained, wherein mulberry fruit total flavonoid content is more than 60%. Raw materials are rich, a preparation method is simple, and the obtained mulberry fruit extract has hypoglycaemic effect, can be used for preparing the hypoglycaemic agent and has good economic and social benefits.

Description

Technical field [0001] The invention relates to medicine, in particular to the application of a mulberry extract in the preparation of a hypoglycemic medicine. Background technique [0002] Mulberry is the mature fruit of the deciduous tree mulberry tree of the Moraceae family. Mulberry is also called mulberry fruit, mulberry jujube, and mulberry. People like to eat the ripe fresh fruit, which is sweet and juicy. It is one of the fruits that people often eat. Mature mulberries are oily, sweet and sour, preferably large, thick, purplish-red, and rich in sugar. From April to June each year, the fruits are harvested when they are ripe, washed, removed from impurities, sun-dried or slightly steamed and dried for consumption. It can also be used for making wine. Sweet, sour, cold in nature, enters the liver and kidney meridian, has the effects of nourishing yin and blood, nourishing body fluid, moisturizing dryness, moisturizing the intestines and detoxification, nourishing yin, nour...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/605A61P3/10
Inventor 苗明三王凤杰白明
Owner HENAN UNIV OF CHINESE MEDICINE
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