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A kind of industrial preparation method of medicinal simethicone oil

A technology for dimethyl silicone oil and hexamethyldisiloxane, which is applied in the field of preparing medicinal dimethyl silicone oil, can solve the problems of low product viscosity, complicated operation and the like, and achieves strong catalytic activity, low environmental pollution and production cost. low effect

Active Publication Date: 2017-03-22
CHONGQING KANGLE PHARMA
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] The technical problem to be solved by the present invention is to provide an industrial production method of pharmaceutical simethicone oil, which uses octamethylcyclotetrasiloxane and hexamethyldisiloxane as raw materials and acid sulfate as a catalyst to produce pharmaceutical The use of simethicone oil solves the common defects of cumbersome operation and low product viscosity in industrial production methods, and the quality index of medicinal simethicone oil obtained by this method stably meets the requirements of the 2010 edition of "Chinese Pharmacopoeia"

Method used

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  • A kind of industrial preparation method of medicinal simethicone oil
  • A kind of industrial preparation method of medicinal simethicone oil

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] In the reaction kettle, add 60.0Kg of octamethylcyclotetrasiloxane (D4) and 1.0Kg of hexamethyldisiloxane (MM) respectively, start stirring, control the speed at 90~100 rpm, start heating, and then Add 3.05 Kg of sodium bisulfate, raise the temperature to 80°C±2°C and keep it warm for 4 hours, cool to 50°C±5°C after the reaction, and press filter to obtain crude simethicone oil.

[0031] Transfer the crude product to the rectification kettle with nitrogen, start the stirring, control the speed at 90~100 rpm, start the vacuum, control the vacuum degree ≤ -0.09MPa, raise the temperature to 150°C~180°C, and conduct the rectification operation for 3~4 hours, then Cool to 50°C±5°C, and obtain 58.2Kg of medicinal simethicone oil after fine filtration, with a weight yield of 95.4%. Product viscosity is 848.5mm 2 / s, and other quality indicators meet the requirements of the 2010 edition of "Chinese Pharmacopoeia".

Embodiment 2~8

[0033] Based on Example 1, by only changing one of the three items of catalyst dosage, the ratio of D4 and MM, and reaction temperature, and keeping the other conditions unchanged (the following table uses "--" to indicate that the conditions are the same as Example 1), we can obtain The results are as follows:

[0034] Table 1

[0035] sequence The amount of catalyst Ratio of D4 to MM temperature yield viscosity other indicators 2 4.58Kg -- -- 95.5% 853.9mm 2 / s

Embodiment 9

[0037] In the reaction kettle, add 80.0Kg of octamethylcyclotetrasiloxane (D4) and 1.0Kg of hexamethyldisiloxane (MM) respectively, start stirring, control the speed at 90~100 rpm, start heating, and then Add 6.08 Kg of potassium hydrogen sulfate, raise the temperature to 90°C±2°C and keep it warm for 5 hours, cool to 50°C±5°C after the reaction, and press filter to obtain crude dimethyl silicone oil.

[0038] Transfer the crude product to the rectification kettle with nitrogen, start the stirring, control the speed at 90~100 rpm, start the vacuum, control the vacuum degree ≤ -0.09MPa, raise the temperature to 150°C~180°C, and conduct the rectification operation for 3~4 hours, then Cool to 50°C±5°C, and obtain 76.3Kg of medicinal simethicone oil after fine filtration, with a weight yield of 94.2%. Product viscosity is 710.4mm 2 / s, and other quality indicators meet the requirements of the 2010 edition of "Chinese Pharmacopoeia".

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Abstract

The invention discloses an industrialized preparation method of medicinal dimethyl silicone oil. By using acid sulfate as a catalyst, octamethylcyclotetrasiloxane (D4) and hexamethyl disiloxane (MM), which are cheap and commercially accessible, are utilized to prepare the medicinal dimethyl silicone oil which satisfies the medicinal requirements. The method is simple, the whole technique is convenient to operate, the catalyst is cheap, simple and accessible, and the obtained product has the advantages of high quality and high yield; and thus, the method is more suitable for industrial production.

Description

technical field [0001] The invention belongs to the technical fields of medicine and chemical industry, and in particular relates to an industrialized method for preparing medicinal simethicone oil. Background technique [0002] Dimethicone is polydimethylsiloxane, the CAS number is 63148-62-9, and its chemical structure is as follows: [0003] [0004] Medicinal simethicone oil can be used as raw material medicine, has defoaming effect, and can be made into oral gastrointestinal anti-bloating tablets and pulmonary edema defoaming aerosol and other drugs. Simethicone oil can also be used as a pharmaceutical excipient and is widely used in various aspects of preparation production, preparation of antacid capsules, polishing agent for sugar-coated tablets, film coating materials, the best condensing agent for water-soluble dropping pills, micropowder and The only effective antistatic agent in the production of pellets, used as a lubricant in solid preparations, as a releas...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G77/08
Inventor 唐明胡红英黄宏章俊杨继斌蔡中文查正华王亚川
Owner CHONGQING KANGLE PHARMA