A traditional Chinese medicine composition and its application in the preparation of medicines for treating nephrotic syndrome
A technology of composition and traditional Chinese medicine, applied in the directions of drug combination, pharmaceutical formula, plant raw material, etc., can solve the problems of large side effects, low treatment efficiency of nephrotic syndrome, easy recurrence, etc.
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0023] Example 1 Clinical trial
[0024] (1) Case selection
[0025] Between May 2010 and May 2013, 60 patients with nephrotic syndrome were screened, all of whom had clinical manifestations of varying degrees of edema, massive proteinuria, and hypoalbuminemia. Laboratory examination results indicated that urine protein exceeded 3.5g / 24h , Plasma albumin is less than 30g / L, in line with the diagnostic criteria in the 2003 "Nephropathy Diagnosis and Treatment and Curative Effect Criteria Symposium", and exclude the secondary caused by systemic lupus erythematosus, diabetes, hypertension, purpuric nephritis, etc. Nephrotic syndrome.
[0026] (2) Case data
[0027] The 60 patients included in the observation, aged between 22-61 years old, with a course of 7-96 months, were grouped according to the random number form blind method, 30 cases in the experimental group and 30 cases in the control group. There were 18 males and 12 females in the experimental group, with an average age of 46....
Embodiment 2
[0051] Example 2 Clinical trial
[0052] (1) Case selection
[0053] From February 2010 to January 2014, 108 patients with nephrotic syndrome were selected as observation objects, and the selection criteria were the same as in Example 1.
[0054] (2) Case data
[0055] The 108 patients included in the observation were aged between 3-58 years old and the disease course was 6-72 months. They were grouped according to the random number table blinding method, including 54 cases in the experimental group and 54 cases in the control group. There were 28 males and 26 females in the experimental group, with an average age of 29.01±7.23 years and an average course of 38.52±13.41 months; the control group had 25 males and 29 females with an average age of 31.09±6.49 years and an average course of 39.14±13.63 months. There was no difference in age, gender, smoking, drinking, weight, education level, etc. between the two groups, and they were comparable.
[0056] (3) Treatment methods
[0057] The...
Embodiment 3
[0078] Example 3 Specific test cases
[0079] 1. Name: Qin × × Gender: Male Age: 24
[0080] In September 2010, the patient developed edema of the eyelids and lower extremities for no obvious cause or cause, accompanied by oliguria, increased foam in the urine, and waist and knee weakness. The edema gradually increased and spread to the whole body. Hospital laboratory tests showed: total protein 40.6g / L, albumin 23.4g / L, total cholesterol 10.9mmol / L, urine protein quantitative 7.66g / 24h, urine protein 3+, occult blood -. Renal biopsy revealed: "minimal change nephropathy". When oral prednisone 60mg / d was given, it became negative after 2 weeks, and the dose was reduced by 5mg every month. During the reduction process, there were multiple recurrences. When the hormone was reduced to 5mg / d, urine protein appeared again, accompanied by both lower limbs. Edema.
[0081] Tested in October 2011 for urine protein 2+, albumin 30g / L, total cholesterol 6.20mmol / L, urinary protein quantitati...
PUM
Login to View More Abstract
Description
Claims
Application Information
Login to View More