Modification method of titanium metal having antibacterial property and capable of promoting growth of osteoblast
A technology of osteoblasts and titanium metal, applied in the field of surface modification of biomedical materials, can solve the problems of removal of implants, antibiotic treatment, high infection rate, etc., to prevent coating from falling off, good biocompatibility, and preparation method simple effect
Active Publication Date: 2015-01-07
陕西德健众普生物科技有限公司
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However, the infection rate of this type of surgery is high, which may lead to serious consequences such as heavy antibiotic treatment, removal of implants and even death
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Embodiment 1
[0029] Step 1, pretreatment of titanium metal, ultrasonic treatment of titanium metal in 20ml 1mol / L acetone solution 3 times, each time for 45 minutes, then put into 30ml of nitric acid solution with a volume fraction of 40% for 25 minutes, at a pressure of 0.3 MPa, the temperature is 80°C, and dried for 10 minutes to obtain pretreated titanium metal;
[0030] Step 2, coating preparation, soak the pretreated titanium metal in 50ml 1mg / mL dopamine aqueous solution for 24 hours to obtain the coated titanium metal;
[0031] Step 3, the introduction of osteoblasts, get 2.5g of chitosan whose terminal group is carboxyl molecular weight and be dissolved in 50ml distilled water containing 0.5mmol acetic acid to obtain chitosan solution; get 0.2g epichlorohydrin and dissolve in 10ml ethanol to obtain epichlorohydrin solution; get 0.01g silver nitrate and dissolve it in 1ml distilled water to obtain silver nitrate solution, mix the three kinds of solutions to obtain a mixed solution w...
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The invention discloses a modification method of titanium metal having antibacterial property and capable of promoting the growth of osteoblast. The modification method comprises the following steps: pretreating titanium metal, preparing a mixed liquid which can be adhered on the surface of the titanium metal and contains a certain crosslinking space structure, wherein the mixed liquid contains silver nitrate with an antibacterial function; then adding osteoblast and the pretreated titanium metal, and performing vacuum drying to obtain titanium metal the coating of which is coated by osteoblast; and finally immersing into a pancreatin solution for 15-45 seconds, performing ultrasonic elution and vacuum drying to obtain modified medical titanium metal capable of promoting the growth of osteoblast. The method is simple, and mild in preparation conditions, no harmful substances are generated during preparation, the modified titanium metal can effective recognize osteoblast, promote the fast growth of the osteoblast on the surface of the titanium metal, and effectively inhibit the growth of bacteria; and after being implanted into a human body as an implant, the modified titanium metal is beneficial to fixed growth of osteoblast on the surface of the titanium metal.
Description
technical field [0001] The invention relates to the field of surface modification of biomedical materials, in particular to a method for modifying titanium metal which has antibacterial properties and promotes the growth of osteoblasts. Background technique [0002] With the development of medical technology, medical titanium metal is widely used as implant materials such as dental implants and bone implants in the treatment of dentition defects, bone loss and other diseases, and has played an important role in saving human lives. However, the infection rate of this type of operation is high, which may lead to serious consequences such as heavy antibiotic treatment, removal of implants and even death. There are two main reasons for the high incidence of implant-associated infection: the accumulation of bacterial plaque on the implant surface and the low resistance of the implant osseointegration interface. Therefore, there is a need to improve the antibacterial properties o...
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IPC IPC(8): A61L27/54A61L27/38A61L27/06
Inventor 李培源苏炜霍丽妮陈睿
Owner 陕西德健众普生物科技有限公司