Method for dropping drop pills by vibration

Abstract

The invention relates to a preparation process of drop pills and particularly relates to a drop pill preparation method which has high drug loading capacity, and is simple in preparation procedure and high in production speed. The method comprises the following steps: (1) heating and fusing drugs and auxiliary base materials; (2) conveying fused drug liquid to a dropping head and dropping out the drug liquid by using a vibration dropping method; (3) cooling by low-temperature gas to obtain the drop pills.

Description

technical field [0001] The invention relates to a preparation process of drop pills, in particular to a method for preparing drop pills with high drug loading, simple preparation process and high production rate; the method can be used to prepare high drug load micropills and coated drop pills and drop pill capsules. Background technique [0002] Dropping pills are the traditional dosage form of traditional Chinese medicine preparations. Its advantages are: short production cycle, no dust pollution; high bioavailability, rapid onset, long-term effect of local administration; can reduce drug volatilization and increase drug stability; And easy to carry and store. [0003] However, the traditional drop pill preparation process is obtained by dropping the melted material into an immiscible cooling medium. Since it mainly depends on the falling gravity, the surface tension of the liquid medicine and the internal stress to form it, the amount of matrix used is large. The drug l...

AI Technical Summary

Problems solved by technology

[0003] However, the traditional drop pill preparation process is obtained by dropping the melted material into an immiscible cooling medium. Since it mainly depends on the falling gravity, the surface tension of the liquid medicine and the internal stress to form it, the amount of matrix used is large. The drug loading per unit is small, and the drug loading of the main drug is generally only about 25%, which does not meet the international market's limit on the maximum daily dosage of PEG excipients not exceeding 700mg, and cannot meet the requirements of the international market

Moreover, it is very difficult to make drop pills with a particle size of less than 2.5mm in the traditional drop pill process. Patients need to take a large number of pills that are difficult to swallow each time, which does not meet the modern fast-paced requirements, and is prone to problems such as inaccurate doses, which is not easy for international acceptance.

The frequency of dripping is low, the roundness is not enough, the weight of the pills and the size of the dripping pills are quite different, in order to ensure the effect of dripping, a large amount of matrix needs to be added, resulting in a small drug loading per unit and a large dose of medicine; use cooling liquid to solidify the dripping pills , needs to be added to the post-oil removal process, and there will be organic solvent residues caused by the coolant cannot be removed

[0004] Using the traditional drop pill drying method takes a long time, slow speed, and uneven drying, which may easily cause the volatilization of products containing volatile oil or the precipitation of borneol in the drying process of substances containing borneol