Method for dropping drop pills by vibration

A technology for preparing dripping pills and dropping pills, which is applied in the direction of making medicines into special physical or taking forms of devices, which can solve the problems of large dosage, inaccurate dosage, and slow speed, and reduce the amount of excipients and dosage , Reduce drying time, simplify the operation process

Inactive Publication Date: 2015-01-14
TIANJIN TASLY PHARMA CO LTD
View PDF4 Cites 6 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the traditional drop pill preparation process is obtained by dropping the melted material into an immiscible cooling medium. Since it mainly depends on the falling gravity, the surface tension of the liquid medicine and the internal stress to form it, the amount of matrix used is large. The drug loading per unit is small, and the drug loading of the main drug is generally only about 25%, which does not meet the international market's limit on the maximum daily dosage of PEG excipients not exceeding 700mg, and cannot meet the requirements of the international market
Moreover, it is very difficult to make drop pills with a particle size of less than 2.5mm in the traditional drop pill process. Patients need to take a large number of pills that are difficult to swallow each time, which does not meet the modern fast-paced requirements, and is prone to problems such as inaccurate doses, which is not easy for international acceptance.
The frequency of dripping is low, the roundness is not enough, the weight of the pills and the size of the dripping pills are quite different, in order to ensure the effect of dripping, a large amount of matrix needs to be added, resulting in a small drug loading per unit and a large dose of medicine; use cooling liquid to solidify the dripping pills , needs to be added to the post-oil removal process, and there will be organic solvent residues caused by the coolant cannot be removed
[0004] Using the traditional drop pill drying method takes a long time, slow speed, and uneven drying, which may easily cause the volatilization of products containing volatile oil or the precipitation of borneol in the drying process of substances containing borneol

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0034] Example 1 Preparation of Compound Danshen Dripping Pills

[0035] Get 600g of Danshen Sanqi extract, 5g of borneol, and 2000g of PEG-6000 auxiliary material. First add PEG-6000 into the chemical tank, heat it to 90°C, melt it in advance, then add the extract of Danshen notoginseng, mix well to form a liquid. Adjust the vibration frequency of the pneumatic vibrating dripper to 50Hz, the dripper is kept warm with a steam jacket, and the temperature is controlled at 80°C. The liquid medicine flows into the dripper through pressurization, and drips out from the bottom of the dripper into the cooling pipe. It is cooled by low-temperature inert gas, and the cooling temperature is -20°C, so that the dripping liquid medicine is cooled into a solid drop pill. Then the dropping pills are subjected to fluidized drying and drug-loaded coating, and the drying temperature is 75 degrees. The prepared pellets with a particle size of 1.0-2.0 mm are filled into capsules, and 100% onli...

example 2

[0037] Example 2 prepares Danshen dripping pills

[0038] Take 600g of salvia miltiorrhiza extract, add 60g of water, add 1500g of PEG-6000 auxiliary material, put it into a chemical tank and heat to 90°C, make it melt completely and mix evenly into a liquid. The medicinal liquid is pressurized and transported to the dripper, the dripping vibration frequency is 20Hz, infrared heating is used for heat preservation, and the dripping temperature is controlled at 80°C. It is cooled by low-temperature nitrogen, and the cooling temperature is -10°C. Then carry out fluidized drying at 40°C and drug-loaded coating, pass through sieve pellets and granulate, and finally pack into the final product.

example 3

[0039] Example 3 Preparation of Huoxiangzhengqi Dropping Pills

[0040]Take Huoxiangzhengqi Extract 200g. Add 1ml of patchouli oil, 2ml of perilla leaf oil, and 600g of polyethylene glycol into the chemical tank at the same time, heat to 65-85°C, melt, and mix evenly to form a liquid. The liquid medicine flows into the dripper through pressurization, and drips out from the bottom of the dripper into the cooling pipe. Adjust the vibration frequency of the electric vibrating dripper to 200Hz, and the heat preservation room adopts an electric heating jacket for heat preservation, and the temperature is controlled at 80°C. It is cooled by low-temperature nitrogen, and the cooling temperature is -20°C. Then carry out fluidized drying at 60°C, coat with 15% coating solution, and pass through sieve pellets and granules, and finally pack into the final product.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Viscosityaaaaaaaaaa
Particle sizeaaaaaaaaaa
Diameteraaaaaaaaaa
Login to view more

Abstract

The invention relates to a preparation process of drop pills and particularly relates to a drop pill preparation method which has high drug loading capacity, and is simple in preparation procedure and high in production speed. The method comprises the following steps: (1) heating and fusing drugs and auxiliary base materials; (2) conveying fused drug liquid to a dropping head and dropping out the drug liquid by using a vibration dropping method; (3) cooling by low-temperature gas to obtain the drop pills.

Description

technical field [0001] The invention relates to a preparation process of drop pills, in particular to a method for preparing drop pills with high drug loading, simple preparation process and high production rate; the method can be used to prepare high drug load micropills and coated drop pills and drop pill capsules. Background technique [0002] Dropping pills are the traditional dosage form of traditional Chinese medicine preparations. Its advantages are: short production cycle, no dust pollution; high bioavailability, rapid onset, long-term effect of local administration; can reduce drug volatilization and increase drug stability; And easy to carry and store. [0003] However, the traditional drop pill preparation process is obtained by dropping the melted material into an immiscible cooling medium. Since it mainly depends on the falling gravity, the surface tension of the liquid medicine and the internal stress to form it, the amount of matrix used is large. The drug l...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61J3/06
Inventor 闫希军孙小兵
Owner TIANJIN TASLY PHARMA CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap