The invention relates to the preparation process of a drop pill, in particular to a method for preparing the drop pill. The method is high in medicine loading capacity, simple in preparation procedure and high in production speed. The method comprises the following steps of (1) a material melting step, i.e. putting a medicine and a base material in the weight ratio of 1:5-5:1 into a homogenizer, homogenizing and mixing the materials at the rotation speed of 1,000 to 5,000 rpm for 1 to 200 minutes, and homogenizing the mixture at the rotation speed of 3,000 to 10,000 rpm for 1 to 100 minutes at the temperature of 60 to 100 DEG C to melt the materials, and obtaining a liquid intermediate material; (2) a dropping step, i.e. performing vibration dropping on the liquid intermediate material by a dripper, wherein the vibration frequency is 2 to 2,000Hz, the acceleration speed is 1 to 15G, the dropping pressure is 0.5 to 4.0 Bar, the dripper temperature is 70 to 200 DEG C, and the dropping speed is matched with the material melting speed in the step (1); (3) a condensing step, i.e. quickly cooling and condensing medicine drops which are formed by dropping into uncoated drop pills with the diameter of 0.2 to 4.0mm in a condensing agent, wherein a condensate is selected from liquid paraffin, methyl silicone oil, coal oil or a mixture of the liquid paraffin, the methyl silicone oil and the coal oil, the temperature of the condensate is 30 DEG C below zero to 80 DEG C, and the cooling time is not smaller than 30 seconds.