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Method for preparing drop pill by high-speed vibration in dropping way

A drop pill and drop system technology, applied in the direction of making medicines into special physical or taking form devices, etc., can solve problems such as clogging of the dripper, inability to cut materials effectively, and reduce auxiliary materials, expand production capacity, and reduce the amount of auxiliary materials. Effect

Inactive Publication Date: 2015-01-14
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The electric method cannot effectively cut the material, causing the dripper to be blocked and affecting the preparation of the dropping pills, the pneumatic vibration method can be used

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1 Compound Danshen Dripping Pills

[0029] Get 600g of Danshen Sanqi extract, 5g of borneol, and 2000g of PEG-6000 auxiliary material. First add PEG-6000 into the chemical tank, heat to 90°C, melt in advance, then add Danshen Sanqi extract, borneol, mix well to form a liquid. Adjust the vibration frequency of the pneumatic vibrating dripper to 140Hz, the acceleration to 3.5-4.5G, the dripping pressure to 1.8Bar, and the temperature of the dripper to be 75-85°C. The dripper is kept warm with a steam jacket, and the temperature is controlled at 80°C. The liquid medicine flows into the dripper through pressurization, and drips out from the bottom of the dripper into the cooling pipe. Liquid paraffin is used, the cooling temperature is -10°C, and the cooling time is not less than 30s, so as to ensure that the dripping pills are fully cooled so that the dropped medicinal liquid is cooled into solid dripping pills. The drop pills with a particle size of 1.0-2.0mm ar...

Embodiment 2

[0030] Example 2 Preparation of Salvia Miltiorrhiza Dropping Pills

[0031] (1) Material preparation step: 600g of Salvia miltiorrhiza extract, add 3000g of PEG-6000 auxiliary material into the homogenizer, homogeneously mix at 1000rpm for 1min, and then homogenize the material at 3000rpm for 1min at a temperature of 60°C to obtain an intermediate material (2) Dropping step: the intermediate feed liquid is dripped by dripper vibration, the vibration frequency is 50Hz, the dripping pressure is 0.5Bar, the dripper temperature is 70°C, and the dripping speed matches the speed of the chemical material in step (1). (3) Condensation step: the dripping pills with a diameter of 0.2mm are rapidly cooled and solidified by dripping drops in a condensing agent, and the condensate is selected from liquid paraffin, methyl silicone oil, kerosene or their mixture, The temperature of the condensate is -30°C, and the cooling time is not less than 30 seconds. Then carry out fluidized drying and...

Embodiment 3

[0032] Example 3 Preparation of Huoxiangzhengqi Dropping Pills

[0033] (1) Material preparation step: take Huoxiangzhengqi extract 200g. Put 1ml of patchouli oil, 2ml of perilla leaf oil, and 40g of polyethylene glycol into a homogenizer, mix homogeneously at 5000rpm for 200min, then homogenize the material at 10000rpm for 100min at a temperature of 100°C to obtain an intermediate material liquid ; (2) Dropping step: the intermediate material liquid is dripped by dripper vibration, the vibration frequency is 300Hz, the dripping pressure is 4.0Bar, the dripper temperature is 300°C, and the dripping speed matches the speed of the chemical material in step (1); (3) Condensation step: the dripping pills with a diameter of 4.0mm are rapidly cooled and solidified by the dropped medicine droplets in a condensing agent, and the condensed liquid is selected from liquid paraffin, methyl silicone oil, kerosene or their mixture, so The temperature of the condensate is 10°C, and the cool...

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PUM

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Abstract

The invention relates to the preparation process of a drop pill, in particular to a method for preparing the drop pill. The method is high in medicine loading capacity, simple in preparation procedure and high in production speed. The method comprises the following steps of (1) a material melting step, i.e. putting a medicine and a base material in the weight ratio of 1:5-5:1 into a homogenizer, homogenizing and mixing the materials at the rotation speed of 1,000 to 5,000 rpm for 1 to 200 minutes, and homogenizing the mixture at the rotation speed of 3,000 to 10,000 rpm for 1 to 100 minutes at the temperature of 60 to 100 DEG C to melt the materials, and obtaining a liquid intermediate material; (2) a dropping step, i.e. performing vibration dropping on the liquid intermediate material by a dripper, wherein the vibration frequency is 2 to 2,000Hz, the acceleration speed is 1 to 15G, the dropping pressure is 0.5 to 4.0 Bar, the dripper temperature is 70 to 200 DEG C, and the dropping speed is matched with the material melting speed in the step (1); (3) a condensing step, i.e. quickly cooling and condensing medicine drops which are formed by dropping into uncoated drop pills with the diameter of 0.2 to 4.0mm in a condensing agent, wherein a condensate is selected from liquid paraffin, methyl silicone oil, coal oil or a mixture of the liquid paraffin, the methyl silicone oil and the coal oil, the temperature of the condensate is 30 DEG C below zero to 80 DEG C, and the cooling time is not smaller than 30 seconds.

Description

technical field [0001] The invention relates to a preparation process of dropping pills, in particular to a preparation method of dropping pills with high drug loading, simple preparation process and high production rate. Background technique [0002] Dropping pills are the traditional dosage form of traditional Chinese medicine preparations. Its advantages are: short production cycle, no dust pollution; high bioavailability, rapid onset, long-term effect of local administration; can reduce drug volatilization and increase drug stability; And easy to carry and store. [0003] However, the traditional drop pill preparation process adopts the natural drop method, and the molten material is dropped into an immiscible cooling medium to obtain it. Since it mainly depends on the falling gravity, the surface tension of the liquid medicine and the internal stress to form, the dropped pill The frequency of preparation is low, the roundness is not enough, the weight of pills and the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61J3/06
Inventor 章顺楠闫希军董海鸥荣昌盛叶正良孙小兵王世庆张洪波陈聪李晨鸣郑永锋范立君
Owner TIANJIN TASLY PHARMA CO LTD
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