Application of cyclocarya paliurus in preparation of medicine used for inhibiting synthesis and secretion of intestinal tract apoB48
A intestinal and drug technology, applied in the direction of drug combination, plant/algae/fungus/moss components, pharmaceutical formulations, etc., can solve the problems of delayed disease, incomplete control of hyperlipidemia, limited development, etc.
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Embodiment 1
[0014] The preparation of embodiment 1 Cyclocarurus alcoholic extract
[0015] Before the leaves of Cyclocarya paliurus are extracted, impurities and thicker branches are removed. Take 2.5 kg of crude drug, use 8 times the amount of 80% ethanol to reflux extract three times, each time for 2 hours, and combine the extracts to obtain 466 g of extract. The extract is dissolved in 0.5% CMC-Na to make a suspension.
Embodiment 2
[0016] The preparation of embodiment 2 serum sample
[0017] 40 male KM mice were adaptively fed for 1 week and randomly divided into two groups, 10 mice in the blank group were given normal feed and water, and the remaining 30 mice in the model group were given high-fat diet for 6 weeks. After 6 weeks, blood was taken from the mouse orbit (fasting for 12 hours before blood collection), centrifuged at 3000r / min for 15 minutes, and serum was taken to measure the fasting total cholesterol (TC) level. Hyperlipidemia was defined as TC>3.85mmol / L (150mg / dL) According to the TC value, they were randomly divided into 3 groups with 10 rats in each group. The hyperlipidemia model group was centrifuged at 3000r / min for 15min, and the serum was taken to measure the fasting total cholesterol (TC) level. With TC>3.85mmol / L (150mg / dL) as the successful model of hyperlipidemia, it was randomly divided into 3 groups according to the TC value. Group, 10 in each group. High-fat model group (H...
Embodiment 3
[0019] The mensuration of embodiment 3 sample apoB48 content
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