Application of cyclocarya paliurus in preparation of medicine used for inhibiting synthesis and secretion of intestinal tract apoB48

A intestinal and drug technology, applied in the direction of drug combination, plant/algae/fungus/moss components, pharmaceutical formulations, etc., can solve the problems of delayed disease, incomplete control of hyperlipidemia, limited development, etc.

Inactive Publication Date: 2015-01-14
JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

By reducing bile acid reabsorption, inhibiting the expression of MTTP and apoB to regulate high lipid levels in the body and the excessive intake of exogenous lipids, but apoB expression inhibitors are mainly focused on the development of apoB-100 lipid-lowering drugs, Therefore, the development of drugs related to intestinal apoB48 is limited, and the hyperlipidemia caused by excessive intake of lipids cannot be completely controlled, resulting in delayed treatment

Method used

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  • Application of cyclocarya paliurus in preparation of medicine used for inhibiting synthesis and secretion of intestinal tract apoB48
  • Application of cyclocarya paliurus in preparation of medicine used for inhibiting synthesis and secretion of intestinal tract apoB48

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] The preparation of embodiment 1 Cyclocarurus alcoholic extract

[0015] Before the leaves of Cyclocarya paliurus are extracted, impurities and thicker branches are removed. Take 2.5 kg of crude drug, use 8 times the amount of 80% ethanol to reflux extract three times, each time for 2 hours, and combine the extracts to obtain 466 g of extract. The extract is dissolved in 0.5% CMC-Na to make a suspension.

Embodiment 2

[0016] The preparation of embodiment 2 serum sample

[0017] 40 male KM mice were adaptively fed for 1 week and randomly divided into two groups, 10 mice in the blank group were given normal feed and water, and the remaining 30 mice in the model group were given high-fat diet for 6 weeks. After 6 weeks, blood was taken from the mouse orbit (fasting for 12 hours before blood collection), centrifuged at 3000r / min for 15 minutes, and serum was taken to measure the fasting total cholesterol (TC) level. Hyperlipidemia was defined as TC>3.85mmol / L (150mg / dL) According to the TC value, they were randomly divided into 3 groups with 10 rats in each group. The hyperlipidemia model group was centrifuged at 3000r / min for 15min, and the serum was taken to measure the fasting total cholesterol (TC) level. With TC>3.85mmol / L (150mg / dL) as the successful model of hyperlipidemia, it was randomly divided into 3 groups according to the TC value. Group, 10 in each group. High-fat model group (H...

Embodiment 3

[0019] The mensuration of embodiment 3 sample apoB48 content

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Abstract

The invention relates to the field of medicines, especially the field of application of cyclocarya paliurus, and in particular relates to an application of cyclocarya paliurus in preparation of a medicine used for inhibiting secretion of apoB48. By utilizing the inhibiting effect of a cyclocarya paliurus alcohol extract to synthesis and secretion of intestinal tract apoB48, the aim of effectively controlling hyperlipidemia caused by long-term excessive ingestion of exogenous lipid is achieved.

Description

technical field [0001] The present invention relates to the field of medicines, in particular to the application field of Cyclocarya paliurus, and more specifically to the application of Cyclocarya paliurus in the preparation of medicines for inhibiting the synthesis and secretion of apoB48. Background technique [0002] Lipid metabolism disorder refers to a high-incidence disease of abnormal blood lipid metabolism in the whole body caused by various reasons. The lipid metabolism disorder in the body will increase blood viscosity, and blood lipids are easily deposited on the blood vessel wall, which is easy to cause atherosclerosis Sclerosis, myocardial infarction, stroke, coronary heart disease and other diseases. [0003] There are two sources of lipids in the body: one is the exogenous lipids from food, which mainly include most triglycerides and a small part of cholesterol, which are absorbed and utilized by the small intestine after digestion; the other is the endogenou...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/52A61P3/06A61P43/00
CPCA61K36/52A61K2236/333
Inventor 张健蒋翠花高萌殷志琦姚楠李玥马永兰林孜
Owner JIANGSU PROVINCE INST OF TRADITIONAL CHINESE MEDICINE
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