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Method for preparing fenofibrate by virtue of intelligent temperature control and remote monitoring

A remote monitoring and fenofibrate technology, which is applied in the field of remote monitoring and preparation of fenofibrate and intelligent temperature control, can solve the problems of the three wastes not being effectively treated, the difficulty of industrialization implementation, and the large amount of acid and alkali. Large-scale industrial production, less impurities and less acid-base dosage

Active Publication Date: 2015-01-14
NANJING GWDR POWER TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] The invention provides a method for preparing fenofibrate with intelligent temperature control and remote monitoring, which is used to solve the problems of the prior art that the amount of acid and alkali is large, the cost is high, the impurities are relatively high, the industrialization is difficult, and the three wastes have not been effectively treated. It has the advantages of high efficiency, low cost, environmental friendliness and easy implementation of industrialization

Method used

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  • Method for preparing fenofibrate by virtue of intelligent temperature control and remote monitoring
  • Method for preparing fenofibrate by virtue of intelligent temperature control and remote monitoring

Examples

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Effect test

Embodiment 1

[0018] Embodiment one: prepare a four-necked flask, two ports of this four-necked flask are provided with electric stirring bar, thermometer respectively, the 3rd port is provided with reflux condenser and water separator, and the 4th port is used for feeding; Add 60g of toluene, 18g of isopropanol, and 6g of concentrated sulfuric acid into the four-necked flask, then add 60g of fenofibric acid under stirring, and stir with an electric stirring bar, and the speed is controlled at 400r~500r / min. Heat to reflux at 110°C to separate the moisture generated by the reaction from the water separator. Toluene, a small amount of water and isopropanol flow back to the four-necked flask through the reflux condenser. When the reaction reaches anhydrous and then enters the water separator, stop heating and Stir, wash the feed liquid left after the esterification reaction with hot water at 60-70°C, separate the impurities and the feed liquid, keep the mixture of the upper layer of material a...

Embodiment 2

[0019] Embodiment two: prepare a four-necked flask, two ports of this four-necked flask are provided with electric stirring bar, thermometer respectively, the 3rd port is provided with reflux condenser and water separator, and the 4th port is used for feeding; Add 72g of toluene, 24g of isopropanol, and 8g of concentrated sulfuric acid into the four-necked flask, then add 60g of fenofibric acid under stirring, and stir with an electric stirring rod, and the speed is controlled at 400r~500r / min. Heat to reflux at 110°C to separate the moisture generated by the reaction from the water separator. Toluene, a small amount of water and isopropanol flow back to the four-necked flask through the reflux condenser. When the reaction reaches anhydrous and then enters the water separator, stop heating and Stir, wash the feed liquid left after the esterification reaction with hot water at 60-70°C, separate the impurities and the feed liquid, keep the mixture of the upper layer of material a...

Embodiment 3

[0020] Embodiment three: prepare a four-necked flask, two ports of this four-necked flask are provided with electric stirring bar, thermometer respectively, the 3rd port is provided with reflux condenser and water separator, and the 4th port is used for feeding; Add 84g of toluene, 30g of isopropanol, and 9g of concentrated sulfuric acid into the four-necked flask, then add 60g of fenofibric acid under stirring, and stir with an electric stirring rod, and the speed is controlled at 400r~500r / min. Heat to reflux at 110°C to separate the moisture generated by the reaction from the water separator. Toluene, a small amount of water and isopropanol flow back to the four-necked flask through the reflux condenser. When the reaction reaches anhydrous and then enters the water separator, stop heating and Stir, wash the feed liquid left after the esterification reaction with hot water at 60-70°C, separate the impurities and the feed liquid, keep the mixture of the upper layer of material...

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Abstract

The invention discloses a method for preparing fenofibrate and specifically relates to a method for preparing fenofibrate by virtue of intelligent temperature control and remote monitoring. The method comprises the following steps: reacting by taking fenofibric acid and isopropanol as raw materials and concentrated sulfuric acid as a catalyst, and after the reaction of the raw materials in the presence of the catalyst is finished, performing water washing, neutralizing, water washing, distilling and purifying operations on the product to obtain the fenofibrate. Besides, toluene is taken as a water-carrying agent, the method has the advantages of mild reaction conditions, short reaction time, convenient after-treatment, low dosage of acid and alkali, few impurities, low environmental pollution, recycling of non-reacting fenofibric acid and the like; the product yield is above 85% and the production cost is low; as a result, the method for synthesizing the fenofibrate is efficient and environment-friendly, and is advantageous to large-scale industrial production.

Description

technical field [0001] The invention relates to a preparation method of fenofibrate, in particular to a method for preparing fenofibrate through intelligent temperature control and remote monitoring. Background technique [0002] Fenofibrate (Fenofibrate), also known as Profafen, chemical name, 2-methyl-[4-(4-chlorobenzoyl)phenoxy]propionate isopropyl ester, is the second generation of phenoxy Acetic acid lipid-lowering drugs have been widely used in France, the United States, Japan and other countries, and have become the first choice for the treatment of hyperlipidemia, and have a strong effect of lowering cholesterol and triglycerides. [0003] Fenofibrate is usually synthesized from fenofibric acid and isopropanol under certain process conditions under the action of a catalyst. [0004] At present, there have been reports on the preparation of fenofibrate in China, but there are problems such as large amount of acid and alkali, high cost, high impurities, difficult indu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C69/708C07C67/08
CPCC07C67/08C07C69/708
Inventor 李敢张丽丽
Owner NANJING GWDR POWER TECH
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