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Novel application of periplaneta americana extractive

A technology of Periplaneta americana and its extract, which is applied in the field of medicine, can solve the problems that have not yet been reported on fractures, etc., and achieve the effect of promoting trabecular bone area, significant curative effect, and promoting callus formation

Inactive Publication Date: 2015-01-28
耿福能
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] There are no relevant reports about the treatment of fractures by Periplaneta americana or its extracts

Method used

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  • Novel application of periplaneta americana extractive
  • Novel application of periplaneta americana extractive
  • Novel application of periplaneta americana extractive

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Embodiment 1: the preparation of American cockroach extract

[0023] Coarsely crush 1000kg of dried Periplaneta americana, add 4 times the amount of 70% ethanol, soak for 1 hour, and extract twice at a temperature of 70°C for 8 hours for the first time; add 3 times the amount of ethanol for the second time, extract for 6 hours and combine Secondary extract, filter, when the filtrate is concentrated to a clear paste with a relative density of 1.09-1.16 (70°C), add water, keep stirring at 70°C for 60 minutes, let stand for 12 hours, discard the upper layer of grease, filter the lower layer of liquid medicine, Recover ethanol from the filtrate, concentrate under reduced pressure to a liquid medicine (70°C) with a relative density of 1.16 to 1.22, add 50ml of glycerin for every 1000ml, stir well, filter, boil the filtrate for 30 minutes, divide into bottles, and then pass through 125°C, The pressure is 0.1Mpa, sterilized for 30 minutes, cooled to room temperature, that is. ...

Embodiment 2

[0024] Embodiment 2: the preparation of American cockroach extract

[0025] Coarsely crush 1000kg of dried Periplaneta americana, add 400kg of water for every 100kg of coarse powder, soak for 1 hour, the temperature is about 70°C, extract three times, the first time is 8 hours; add water 300kg for the second time; extract for 6 hours; thirdly Add water 300kg at a time and extract for 4 hours. Combine the three extracts, filter, and concentrate the filtrate to a relative density of 1.10-1.20 (70°C), add 95% ethanol, keep stirring at 70°C for 30 minutes, let stand for 12 hours, discard the upper layer of grease, filter the lower layer of liquid medicine, Recover ethanol from the filtrate, concentrate under reduced pressure to a relative density of 1.20-1.25 (70°C), add glycerin (50ml glycerin per 1000ml), stir well, and filter to obtain the product.

Embodiment 3

[0026] Embodiment 3: the preparation of American cockroach extract

[0027] Coarsely crush 1000kg of dried Periplaneta americana, add 500kg of water for every 100kg of coarse powder, soak for 2 hours, the temperature is about 80°C, extract three times, the first time is 8 hours; the second time add water 300kg, extract for 6 hours; the third time Add water 300kg at a time and extract for 4 hours. Combine the three extracts, filter, and concentrate the filtrate to a relative density of 1.10-1.20 (70°C), add 95% ethanol, keep stirring at 70°C for 30 minutes, let stand for 12 hours, discard the upper layer of grease, filter the lower layer of liquid medicine, Recover ethanol from the filtrate, concentrate under reduced pressure to a relative density of 1.20-1.25 (70°C), add glycerin (60ml of glycerin per 1000ml), stir well, and filter to obtain the product.

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Abstract

The invention discloses a novel application of a periplaneta americana extractive and in particular discloses a novel application of the periplaneta americana extractive in preparation of a medicament for treating bone fracture. The periplaneta americana extractive is capable of promoting increase of the amount and substance content of callus fibrocyte, area of bone trabecula, osteoblast and osteocyte and facilitating decrease of osteoclast, thus promoting generation of callus, and is also capable of promoting healing of skins at fracture parts. The medicament prepared by singly using periplaneta americana or matching the periplaneta americana and other medicaments is used for treating the bone fracture, is capable of promoting the generation of the callus, promoting the healing of the skins at the fracture parts and shortening treating time, is low in cost, is remarkable in curative effect and is a new choice for clinically treating the bone fracture.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to the new application of the extract of Periplaneta americana. Background technique [0002] Fractures are mostly an acute traumatic disease caused by direct or indirect violence, and the treatment should aim at reducing swelling, relieving pain, and promoting fracture healing. Drugs for invigorating blood circulation, regulating qi and invigorating the kidney are commonly used, administered orally or applied externally. It is important to treat fractures, and often has auxiliary effects such as promoting blood circulation, dispelling blood stasis, reducing inflammation, and relieving pain. [0003] The treatment of fracture healing is divided into three cycles, using three different treatment principles, that is, the famous three-stage treatment method: the hematoma organization stage (the first stage after the fracture, within 1 to 2 weeks after the fracture), mainly using Danshen , Chu...

Claims

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Application Information

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IPC IPC(8): A61K35/64A61P19/08A61P17/02
CPCA61K47/10A61K2236/333A61K2236/35A61K2236/39A61K2236/51A61K2236/53
Inventor 耿福能
Owner 耿福能
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