48 results about "Bone trabeculation" patented technology

The invention discloses bifidobacterium longum subsp.infantis capable of promoting bone growth and a metagen thereof, and belongs to the technical field of biology. The bifidobacterium longum subsp. Infantis CCFM1445 provided by the invention can promote the increase of bone volume fraction, femoral bone trabecula thickness and far-end growth plate thickness of mammals in a growth period, reduce the levels of serum bone resorption markers I-type collagen amino-terminal peptide and tartrate-resistant acid phosphatase, improve the levels of serum bone alkaline phosphatase and parathyroid hormone, and improve the clinical application value of the bifidobacterium longum subsp. Infantis CCFM1445. And the relative abundance of the other bacteria in the intestinal flora and the levels of creatine and indole-3-lactic acid are increased. The thermally inactivated bifidobacterium longum subsp. Infantis CCFM1445 can promote the increase of the volume fraction of femoral bones and the number of bone trabecula of malnourished mice and improve the N-terminal propeptide level of serum I-type procollagen. Therefore, the medicine or health care product prepared from the bifidobacterium longum subsp. Infantis CCFM1445 can be used for assisting in regulating bone metabolism and bone mass, and has a wide market prospect.

The invention relates to the field of disease animal model construction, and particularly discloses a postmenopausal osteoporosis and knee osteoarthritis co-disease animal model construction method which comprises the following steps: selecting a female animal as an experimental subject; the selected female animals are injected with a GnRH agonist, meanwhile, low-calcium feed feeding and oxidative stress stimulation are conducted, and feeding is conducted for a preset time; detecting bone mineral density and bone trabecula parameters of the fed female animals, and screening qualified female animals meeting set standards; performing meniscus tearing operation on the qualified female animal, and implanting sustained release microspheres loaded with inflammatory factors at the torn part during the operation; carrying out weight-bearing training on the female animal after the operation, and continuing for a set time length; and performing health detection on the female animals at different time points. According to the method, through multi-factor collaborative induction of the PMOP, minimally invasive construction of the KOA and multi-dimensional health detection, accurate simulation of a co-disease pathological process and clinical characteristics is realized, and the authenticity and stability of the model are improved.

The invention discloses a titanium-magnesium hollow screw system capable of promoting fracture healing and a manufacturing method. The titanium-magnesium hollow screw system comprises a titanium-based supporting structure and a magnesium filling layer. The titanium-based supporting structure comprises a main body part, the surface of the main body part is provided with an imitated bone trabecula part, and a plurality of bone gaps are formed in the imitated bone trabecula part; wherein bone gaps are filled with the magnesium filling layer, and the magnesium filling layer is combined with the titanium-based supporting structure in a physical embedding mode; the titanium-based supporting structure bears and maintains initial fixation and long-term bearing, so that the strength and the stability of the screw are ensured; the surface imitated bone trabecula and the communicated bone gaps increase the surface area and provide a physical channel for vascularization and bone tissue ingrowth, so that synostosis is promoted; the magnesium filling layer releases magnesium ions after being locally controllably degraded, so that osteogenesis and angiogenesis are favorably stimulated, the local biological environment is improved, instant mechanical support after an operation is ensured, bone healing is promoted through local biological activity release and structural orientation, the healing time is favorably shortened, and the healing quality is favorably improved.

The invention provides application of linariin-6-O-glucoside in preparation of a product for preventing and treating osteoporosis, and relates to the field of biological medicine. According to the invention, dyeing experiments of alkaline phosphatase, alizarin red and tartaric acid resistant acid phosphatase prove that the sesaminin-6-O-glucoside has affinity for FPPS receptors, has the capability of promoting bone marrow mesenchymal stem cells to form bone cells, is superior to that of bisphosphate, and can inhibit the generation of osteoclasts; microCT (micro computed tomography) detection results show that the sesaminin-6-O-glucoside has the effect of relieving the osteoporosis and can promote the formation of bone trabecula. According to the application disclosed by the invention, it is proved for the first time that the sesaminin-6-O-glucoside has the effect of resisting osteoclast formation, and meanwhile, the sesaminin-6-O-glucoside also has a better osteogenesis effect, so that a basis is provided for developing the sesaminin-6-O-glucoside as a potential medicine for treating osteoporosis.

CT images from the neck, lung, cardiac, abdominal, pelvis, hip, spine or lower extremity areas are obtained and analyzed by a computer to measure trabecular bone density on each level it is available, in the spine and hip. Any bone tissue associated with vertebrae that is fractured is excluded, along with Schmorl's nodes, large blood vessels, and cortical bone, to accurately average the trabecular bone density on a scan. The density of fat, heart, and muscle tissue of a subject is used to calibrate the results. That data may be input to an absolute fracture risk model (Fracture Risk Algorithm calculator). Information such as bone density, T score, Z score, fracture risk, and identification of vertebral fractures (if present) may be determined and reported.

The invention discloses a method for preparing a phosphorylated salmon collagen peptide-calcium chelate by taking salmon collagen peptide as a raw material, preparing high-calcium binding active peptide (P-CP) through phosphorylation modification and chelating the high-calcium binding active peptide with calcium ions. The method comprises the following steps: (1) enzymolysis preparation of salmon bone collagen; (2) phosphorylation modification of a peptide fragment mediated by sodium tripolyphosphate; and (3) optimizing a calcium ion chelation process. The chelating rate of the obtained P-CP-Ca calcium reaches 91.21%, and structural characterization proves that a phosphate group (PO4 < 2->) is combined with calcium ions through ionic bonds. Animal experiments show that P-CP-Ca can significantly improve the serum calcium level of a calcium-deficiency mouse (the H group recovers to a normal range), reduce the activity of a bone resorption marker TRAP (Target Related Amplified Protein) (which is 25.4% lower than that of a model group), and improve the bone trabecula microstructure (the bone mineral density is improved by 32.7%). The invention provides a new technology for valuable utilization of fishery by-products and development of functional calcium supplements.

The utility model belongs to the technical field of orthopedic implants, and particularly relates to a porous bone grafting-free window type interbody fusion cage. The multi-hole type bone grafting window-free interbody fusion cage comprises a frame body which comprises four side faces and two end faces, and the four side faces are of hollow structures; the space defined by the frame body is filled with the porous structure body; the meshing teeth are arranged on the upper surface and the lower surface of the frame body; and the clamping structure is arranged at one end part of the frame body. According to the multi-hole type bone grafting-free window type interbody fusion cage, due to the design of the bone grafting-free window, the complexity of the using process is reduced, the operation is convenient, and the possibility that the fusion cage is polluted is reduced; the porous structure body with the bionic bone trabecula can be printed through 3D printing, and pore channels for bone tissue to grow in and a surface beneficial to cell adhesion can be effectively provided; the hydroxyapatite coating improves the biological activity of the surface of the base material and enhances the interface integration of the interbody fusion cage and the upper and lower end plates of the vertebral body.

The invention provides a bone evaluation method based on neural network enhancement and finite element analysis. The bone evaluation method comprises the following steps: acquiring an ultrahigh-resolution CT image of a living vertebra; performing domain conversion processing on the CT image by adopting a generative neural network; carrying out resampling and segmentation on the enhanced CT image; constructing a bone trabecula microstructure model in the cancellous bone mask area; assembling the RVE unit and the cortical bone model into a complete vertebral finite element model, and applying a multi-working-condition load to the RVE unit to calculate anisotropic material parameters; and carrying out axial compression finite element analysis on the complete centrum model, and judging the bone health state. According to the method, information of two dimensions of bone mass and bone, especially contribution of a bone trabecula microstructure to bone strength, is comprehensively considered, bone degeneration and fracture high-risk patients can be recognized earlier, and a scientific basis is provided for clinical early intervention.

The invention discloses a bone trabecular bionic implant, and relates to the field of bone trabecular bionic planting, the bone trabecular bionic implant comprises a bone trabecular bionic body, the lower end of the bone trabecular bionic body is fixedly connected with a fixed threaded part, and a reserved filling cavity is formed in the bone trabecular bionic body; an external threaded piece is arranged at the lower end of the bone trabecula bionic body. According to the bone trabecular bionic implant, the whole bone trabecular bionic body is made of a tantalum metal material, the tantalum metal has bone healing force and supporting strength, and the surface of the bone trabecular bionic body is of a porous structure, so that attachment and ingrowth of muscle fulcrums are facilitated, fulcrums are provided for long-term stability of nodules and muscles, exertion of muscle force is facilitated, and the bone trabecular bionic implant has a good application prospect. The bone trabecula bionic body is filled with gel biological factor substances through a reserved filling cavity, the bone trabecula bionic body is mainly applied to implant operation after femoral head necrosis in early and middle stages and drilling decompression, and other drugs can be plugged into micropores in the surface of the bone trabecula bionic body and are slowly released.

The present application relates to a kind of biomimetic reticular nanofiber composite coating and its preparation method and infectious bone defect repair application, belong to biomedical material field.The present application is aimed at solving the technical problem of the poor bone integration of implant in infectious bone defect.The present application provides a kind of biomimetic reticular nanofiber composite coating, which is formed by layer-by-layer self-assembly on the surface of implant by lysozyme amyloid fiber and polyphenols (such as tannin etc.) Form reticular structure, then prepared with bioactive metal ions coordination;The number of coating layers is 4-8 layers.Preparation method includes lysozyme fiberization, alternate deposition and ion loading steps.The composite coating of the present application has broad-spectrum antibacterial, antioxidant stress and promotes osteogenesis function;In animal model, bacterial load is reduced by 80%, bone volume fraction and trabecular bone parameters are significantly improved, and can realize anti-bacterial biofilm infection-antioxidant stress-angiogenesis-promote bone regeneration synergy.

The present disclosure discloses a zonal trabecular femoral condylar component containing zirconium-niobium alloy with an oxidation layer and a preparation method thereof. The preparation method is as follows: using zirconium-niobium alloy powder as a raw material, conducting a 3D printing for one-piece molding, and obtaining intermediate products of the zonal trabecular femoral condylar component containing zirconium-niobium alloy with the oxidation layer, after Sinter-HIP, cryogenic cooling and surface oxidation, the zonal trabecular femoral condylar component containing zirconium-niobium alloy with the oxidation layer is prepared. Partial of the zonal trabecular femoral condylar component containing zirconium-niobium alloy with the oxidation layer is provided with Zonal trabecula.

The present application belongs to the field of foot and ankle surgical implant devices and biomedical material surface engineering technology, and discloses a tibial component of ankle prosthesis with a composite coating, which comprises: a metal substrate which is a bionic trabecular three-dimensional interconnected porous titanium alloy structure, the porosity is 50-80%, the average pore size is 400-900 mu m, and the connected porosity is greater than or equal to 85%, so that the elastic modulus is controlled in the range of 5-20 GPa, and is matched with the cancellous bone of the tibia; a composite functional coating is in situ grown on the surface of the metal substrate, and the composite functional coating comprises a bioactive layer and a functional ion doped layer. The tibial component of the present application comprises a porous titanium alloy metal substrate and a composite functional coating constructed in situ on the surface thereof, the porous titanium alloy substrate is designed in a bionic trabecular structure to form a three-dimensional interconnected porous structure, so as to provide an elastic modulus matched with the cancellous bone of the tibia and promote the growth of bone tissue.

This invention discloses a composition with bone-health-promoting functions and its applications, belonging to the field of microbial engineering. The composition comprises milk calcium, colostrum basic protein, and Bifidobacterium breve i1088 powder. The composition provided by this invention, which has a synergistic effect between milk calcium, colostrum basic protein, and Bifidobacterium breve i1088 powder, enhances the conversion rate of calcium from the blood to bone through the action of probiotics, thereby improving the actual utilization rate of calcium and effectively promoting bone health. Experimental data show that this composition significantly increases bone mineral density, bone volume fraction, and trabecular thickness in a female rat osteoporosis model, and significantly reduces trabecular spacing in the same model. The composition provided by this invention is suitable for promoting bone health and preventing and / or improving osteoporosis.

The invention provides a method for predicting spinal refracture of an OVCF patient based on an X-ray image. According to the method, a multi-scale space-time convolutional neural network is adopted to analyze a standardized thoracolumbar spine X-ray image sequence, a vertebral body morphology analysis module, a microstructure texture feature extraction module and a time sequence dynamic modeling module are integrated, and the vertebral body morphology analysis module is used for extracting vertebral body geometric morphology features including the height ratio relation of the front edge, the center and the rear edge; the microstructure texture feature extraction module adopts a multi-direction Gabor filter combination and a local binary mode operator to extract the directivity, density and connectivity features of the bone trabecula; the time sequence dynamic modeling module adopts a hybrid architecture of combining a three-dimensional convolutional neural network with a long-short-term memory network; the system further comprises inter-vertebral-body relevance modeling. According to the method, a multi-task loss function item is adopted for joint optimization. According to the method, the prediction accuracy reaches 92.6%, patients can be divided into three risk levels, and effective decision support is provided for clinical precise prevention and treatment.

The invention discloses an additive-manufactured biological tibia tray prosthesis and a manufacturing method thereof, and relates to the technical field of artificial knee joint prostheses. The biological type tibia support prosthesis comprises four types: a biological type symmetrical tibia support, a biological type symmetrical stemless tibia support, a biological type anatomical tibia support and a biological type anatomical stemless tibia support. The prosthesis mainly comprises a support body, a porous structure, a plug pin and the like, and is integrally formed through an additive manufacturing technology, so that the precision and the strength are ensured. The porous structure is designed to be in an irregular space three-dimensional grid shape, the thickness ranges from 0.6 mm to 1.6 mm, and the porous structure is used for promoting bone trabecula ingrowth and achieving biological fixation. The positioning nail adopts a bullet-shaped design and is provided with an exhaust groove and a notch, so that the installation is simplified and the stability is enhanced. The manufacturing method comprises the steps of design modeling, stress optimization, additive manufacturing and aftertreatment, and the prosthesis is made of a titanium alloy material and meets related international standards. The invention has the advantages of simple installation, reliable fixation, good bone ingrowth effect and the like.

The embodiment of the invention provides a bone evaluation model training method and device and a storage medium. In the embodiment of the invention, a plurality of CT images obtained by scanning a target skeleton of a living object through high-resolution CT equipment are acquired, and the enhanced images are input into an unsupervised clustering algorithm to complete voxel-level segmentation of the bone microstructure through global contrast enhancement and local contrast enhancement of the bone microstructure and a background region. Based on the segmentation result, bone microstructure images are extracted to construct a training sample set, and an attention mechanism is utilized to construct an initial model structure for supervised training, so that a bone evaluation model is obtained. According to the method, the problem of manual labeling is solved by utilizing an unsupervised method, so that bone microstructure segmentation can be efficiently and automatically completed, the recognition accuracy and efficiency of microstructures such as bone trabecula and the like are improved, quantitative analysis on the bone microstructure under a high-resolution CT imaging condition is realized by virtue of supervised model training, and the reliability of bone quality evaluation is improved.

The present disclosure discloses an osteoporosis treatment system, apparatus, and method. According to the present disclosure, the osteoporosis treatment system includes: a solid gel pad that has a groove formed to be inclined in consideration of a main direction of trabeculae for an osteoporosis treatment area of a patient obtained using an imaging device; and a fixing part that fixes the solid gel pad to skins near treatment areas of each patient, wherein a probe of low-intensity pulsed ultrasound is inserted into the groove of the solid gel pad so that pulsed ultrasound applied by the low-intensity pulsed ultrasound amplifies movement of fluid inside a trabecular bone to maximize a response of osteoblasts distributed on a surface of the trabeculae.

The invention relates to application of a TRMT10C agonist TM3 in preparation of a medicine for treating senile osteoporosis, and belongs to the technical field of biological medicines. According to the invention, the TRMT10C agonist TM3 is used for treating senile osteoporosis for the first time. A mouse experiment verifies that the TRMT10C agonist TM3 can inhibit bone loss of a mouse with osteoporosis, increase the bone density, the number of bone trabecula and the volume fraction of the bone trabecula, reduce the separation degree of the bone trabecula and promote bone formation. It is fully proved that the TRMT10C agonist TM3 can be used for treating the senile osteoporosis caused by the fact that the osteogenesis rate is remarkably reduced due to age increase, and therefore the TRMT10C agonist TM3 can be used for preparing the medicine for treating the senile osteoporosis and has important significance in clinical treatment of the senile osteoporosis in the future.

The invention discloses an application of 6-CEPN in preparation of a product for preventing and improving osteoporosis. According to the invention, ovariectomized mice are fed with two doses of 6-CEPN, which discovers that the 6-CEPN can obviously inhibit abnormal weight increase of the mice caused by estrogen decrease and can also improve bone microstructure of the ovariectomized mice; the bone trabecula network structure is adjusted by increasing the bone trabecula connection density, the bone trabecula number and the bone trabecula thickness and reducing the separation degree of the bone trabecula, meanwhile, 6-CEPN can further increase the bone density and the bone volume fraction of ovariectomized mice, increase the rigidity and deflection of bones and improve the bone strength, the effect of high-dose 6-CEPN is larger than that of low-dose 6-CEPN, and the effect of high-dose 6-CEPN is better than that of low-dose 6-CEPN. Therefore, the composition has a dose-dependent effect.

The invention discloses an intramedullary nail for outer side wall smashing type femoral intertrochanteric fracture, and belongs to the field of medical instruments, the intramedullary nail comprises a main nail, the main nail is connected with a tension bolt through a duct adjusting mechanism, and the main nail is provided with a lock nail; the hole channel adjusting mechanism is arranged on the main screw and used for adjusting the neck-shaft angle of the lag screw, the hole channel adjusting mechanism adjusts and changes the installation angle of the lag screw on the main screw through the structure of the hole channel adjusting mechanism, and then adjustment of the neck-shaft angle of the lag screw is achieved. The lag screw can cross the outer side wall to crush a fracture line, the problem of supporting failure caused by the fact that the screw penetrates through the fracture line in traditional fixation is avoided, meanwhile, the tip end of the lag screw is more accurately embedded into a main pressure bone small beam column (PCS) at the proximal end of the femur, and the holding force of the screw to the femoral head is improved; the main nail and the femoral shaft are tightly fixed through transverse locking, and rotation and axial displacement of the main nail in the medullary cavity are limited.

The invention discloses an application of a bone marrow mesenchymal stem cell outer vesicle for inhibiting miR-221-3p and a preparation method of the bone marrow mesenchymal stem cell outer vesicle. Rat bone marrow mesenchymal stem cell outer vesicles (rBMSCs-EVs) are extracted, rBMSCs-EVs (miR-221-3pin-EVs are used for cells, and antiagomiR-221-3p-EVs are used for animals) for inhibiting miR-221-3p are prepared, and in-vitro osteogenic induction differentiation experiments define that the miR-221-3pin-EVs can remarkably inhibit fluorine-induced osteogenic differentiation enhancement. Meanwhile, the fact that the antagomiR-221-3p-EVs can improve the phenomena of bone mineral density increase, bone trabecula number increase, bone trabecula thickening and the like of a sclerotic bone fluorosis rat model in vivo is further proved, and the antagomiR-221-3p-EVs has important significance on clinical treatment of a patient with the bone fluorosis.

The present application relates to the technical field of medical devices, and discloses a knee joint prosthesis, which comprises a trabecular bone type, one side of the trabecular bone type is provided with a front condyle side, the other side of the trabecular bone type is provided with a notch, both ends of the trabecular bone type notch are provided with distal end sides, the upper surface of the distal end side is provided with a trabecular column, one side of the distal end side is provided with a rear condyle side, the side wall of the trabecular bone type is provided with a femoral condyle body, the inside of the trabecular column is provided with a column, one side of the rear condyle side is provided with a femoral component surface, and the outer wall of the femoral component surface is provided with. The femoral side prosthesis realizes better fusion of the femoral side prosthesis and bone tissue, promotes bone ingrowth, and achieves the effect of long-term stable fixation. The problems of poor long-term stability, easy loosening and easy wear of the friction interface of the traditional femoral side prosthesis are solved, and the service life of the prosthesis and the life quality of the patient are improved.

This invention discloses the application of PT-129 in the preparation of drugs for treating rheumatoid arthritis (RA), belonging to the field of RA treatment. This invention is the first to demonstrate that the compound PT-129 can target and intervene in the synovial microenvironment, effectively inhibiting the abnormal activation behaviors of RA fibroblast-like synovial cells (FLS) such as proliferation, migration, and invasion, and downregulating the expression of N-cadherin and MMP3 proteins in synovial tissue. This invention provides a combined drug formulation containing PT-129 and RGFP966. This composition exhibits a significant synergistic effect in vivo, effectively relieving joint swelling, increasing bone density and trabecular bone thickness, reducing trabecular bone separation, thereby inhibiting cartilage degradation and bone destruction. This invention provides a novel targeted drug and combination therapy with definite efficacy for the clinical intervention of RA, possessing extremely high clinical application development value.

This invention provides the application of Neoruscogenin in the preparation of anti-osteoporosis drugs, belonging to the field of pharmaceutical biotechnology. It was found that Neoruscogenin can significantly increase bone volume fraction, bone surface area to tissue volume ratio, bone mineral density, trabecular bone number, and trabecular bone thickness in osteoporotic mice, while significantly reducing trabecular bone separation; that is, Neoruscogenin can alleviate low bone mass in postmenopausal osteoporotic mice. Furthermore, Neoruscogenin treatment for 8 weeks did not significantly affect the major organs of mice, suggesting the biocompatibility of Neoruscogenin.

This invention comprises base plate and glenosphere designs, as well as cutting guides and holder instruments, developed to provide stronger fixation with a more minimally invasive approach to the shoulder in patients undergoing reverse shoulder arthroplasty for any reason. This newly developed technique allows for surgical operation in a more confined space, particularly in challenging cases such as tight shoulders. In addition, it offers advantages such as being usable as an alternative technique in osteoporotic patients with high cortical fixation and in revision surgeries or in cases with reduced bone stock due to various reasons. In standard base plate designs, it is known that fixation is predominantly achieved in the trabecular bone by screws inserted from the reamed peripheral bone surface surrounding the implant. However, in osteoporotic patients, trabecular bone becomes weakened and the bone stock may not provide sufficient support. Furthermore, version differences related to anatomical variations of the glenoid seen among patients may cause problems in component placement and screw insertion if proper preoperative assessment is not performed. Moreover, in classical component design, in order to send the guidewire in the correct direction corresponding to the surface where the central peg will be applied, soft tissue dissection exposing the entire glenoid must be performed. Performing this dissection may pose challenges for the surgeon in tight shoulders, increase the duration of surgery, and carry risks of complications such as instability or injury to neurovascular structures. In addition, in classical component design, the acceptable threshold of contact between the glenoid and base plate is considered to be 80%. If this is not achieved, implant failure may occur after prosthesis application. When the contact surface between the glenoid and base plate falls below 50%, graft application becomes indicated. Although it is a successful method, it is technically demanding, and in cases of graft non-union, alternative options are limited. Another method is the use of augment components for the defective area. This application not only presents high technical difficulty but also requires well-prepared three-dimensional preoperative planning. Custom-made implants are another option and are technically the most laborious and expensive to manufacture. With this invention, compared to previous techniques, the management of glenoid defect and excessive version problems can be achieved by providing higher cortical fixation with anterior-weighted support.

The invention provides a partitioned porous structure ankle joint tibia prosthesis, and relates to the technical field of artificial joint prostheses, the partitioned porous structure ankle joint tibia prosthesis comprises a tibia prosthesis, the upper end face of the tibia prosthesis is of a porous structure, and the lower end face of the tibia prosthesis is of a porous structure. And the pore diameter of the porous structure of the first outer area is different from that of the porous structure of the first inner area. The upper end face of the tibia prosthesis of the ankle joint tibia prosthesis with the partitioned porous structure is provided with the porous structure, the porous structure is divided into the first outer area and the first inner area, the first outer area and the first inner area are different in aperture, and then the first outer area and the first inner area can be matched with a bone trabecula structure at the far end of a tibia in a regional non-uniform distribution characteristic; a porous structure partition of a first outer area and a porous structure partition of a first inner area are arranged on an osseointegration interface in a targeted mode, and therefore bone resorption and secondary prosthesis looseness caused by postoperative stress shielding are reduced.

The application discloses an acetabular cup for acetabular surgery, which adopts a multilayer structure, namely a first acetabular cup and a second acetabular cup, and the two are connected through an acetabular cup spacer block, the acetabular cup spacer block can prevent the relative movement between the first acetabular cup and the second acetabular cup, improve the stability and wear resistance of the acetabular cup, prolong the service life of the acetabular cup, the first acetabular cup and the second acetabular cup are both trabecular bone structure and are both hollow hemispheres, and have high porosity, so that the biomechanical adaptability of the acetabular cup can be improved, the growth of bone tissue and the fixation of the acetabular cup can be promoted, the stress concentration and osteolysis of the acetabular cup can be reduced, the biocompatibility and corrosion resistance of the acetabular cup can be improved, and a plurality of groups of internal thread base holes are formed in the first acetabular cup, the second acetabular cup and the acetabular cup spacer block, so that the installation and fixation of the acetabular cup are facilitated, and thus the accurate positioning and close connection of the acetabular cup are realized.

The application discloses a use of a benzene sulfonamide compound in preparation of a medicine for preventing and / or treating osteoporosis. The application first proposes the use of the benzene sulfonamide compound in the medicine for preventing and / or treating osteoporosis. Experiments show that the benzene sulfonamide compound can significantly improve bone remodeling of mice, inhibit osteoclasts and promote osteoblasts, and maintain bone metabolism balance; meanwhile, the benzene sulfonamide compound can significantly improve bone volume fraction, trabecular bone surface area, trabecular bone thickness, trabecular bone density, trabecular bone number and bone mineral content of old mice, and significantly reduce the trabecular bone gap of the old mice, which indicates that the benzene sulfonamide compound can improve osteoporosis, and has very important significance for drug development and prevention and treatment of the disease in the future.