69 results about "Bone trabeculation" patented technology

The invention discloses an intelligent identification system for an osteoporosis area, belongs to the field of image processing calculation, and aims to solve the problems of limited technical coverage and lack of a dynamic optimization mechanism. In a feature extraction stage, a system combines traditional image processing and deep learning technologies in parallel, extracts bone trabecula multidirectional texture features by using a Gabor filter and a local binary pattern algorithm, analyzes bone contour curvature by combining Sobel edge detection and morphological operation, constructs geometric morphological parameters, and performs feature extraction on the bone trabecula. The local branch focuses on the porosity and arrangement rule of the bone trabecula by adopting a 3D convolutional network, the global branch is embedded into a compression excitation module based on an improved MobileNetV3 network to strengthen the overall morphological expression of the bone, the response intensity of a local microstructure is enhanced by space attention, the weight of global bone topological characteristics is calibrated by channel attention, and a multi-scale splicing strategy is combined, so that the overall morphological expression of the bone trabecula is optimized. And finally, outputting a fusion feature matrix after noise suppression, and remarkably improving the expression ability of pathological features.

The invention belongs to the technical field of biological medicine, and discloses a probiotic agent capable of improving the physiological activity function of vitamin D and maintaining bone health and application of the probiotic agent. The invention provides a probiotic agent composed of bifidobacterium adolescentis and bifidobacterium longum, the probiotic agent can significantly improve the bone mineral density, the bone trabecula thickness, the bone trabecula number, the bone trabecula connectivity and the bone volume fraction of an osteoporosis mouse, and meanwhile, the bone trabecula separation degree of the osteoporosis-removed mouse is significantly reduced; the level of vitamin D metabolites such as 25-hydroxy vitamin D and 1, 25-dihydroxy vitamin D in mouse serum is improved; the content of serum calcium and alkaline phosphatase in serum of mice is reduced, and the level of osteocalcin and type I procollagen amino terminal peptide in the serum is improved. The probiotic agent can relieve bone calcium loss, maintain bone health, repair bone injury, increase osteoblasts and reduce the osteoporosis degree, and can be used for preparing drugs for preventing and / or treating osteoporosis or preparing health care products or food beneficial to improving bone mineral density.

The invention discloses bifidobacterium longum subsp.infantis capable of promoting bone growth and a metagen thereof, and belongs to the technical field of biology. The bifidobacterium longum subsp. Infantis CCFM1445 provided by the invention can promote the increase of bone volume fraction, femoral bone trabecula thickness and far-end growth plate thickness of mammals in a growth period, reduce the levels of serum bone resorption markers I-type collagen amino-terminal peptide and tartrate-resistant acid phosphatase, improve the levels of serum bone alkaline phosphatase and parathyroid hormone, and improve the clinical application value of the bifidobacterium longum subsp. Infantis CCFM1445. And the relative abundance of the other bacteria in the intestinal flora and the levels of creatine and indole-3-lactic acid are increased. The thermally inactivated bifidobacterium longum subsp. Infantis CCFM1445 can promote the increase of the volume fraction of femoral bones and the number of bone trabecula of malnourished mice and improve the N-terminal propeptide level of serum I-type procollagen. Therefore, the medicine or health care product prepared from the bifidobacterium longum subsp. Infantis CCFM1445 can be used for assisting in regulating bone metabolism and bone mass, and has a wide market prospect.

The invention relates to the field of medical imaging analysis, and discloses a bone trabecula feature construction method and system, and the method comprises the steps: preferentially extracting a fragile region from an obtained vertebral image sequence, and generating an initial feature set representing the stability of a fine-grained structure; performing coherence comparison on the initial feature set in a cross-slice dimension to obtain a composite feature vector capable of reflecting the vulnerability level of the structure; based on the composite feature vector, a connectivity change curve of the bone trabecula in a loading environment is extracted by adopting a multi-layer progressive clustering mode, and candidate bone trabecula units with potential micro-damage trends are marked; classifying the candidate bone trabecula units according to risk gradients, and reconstructing a bone trabecula local topology network with weight levels; and according to the local topology network, identifying high-risk nodes showing an imbalance tendency in a specific mechanical simulation period, and generating a feature construction path finally used for micro-fracture risk prediction. The method has the advantage of improving the micro-fracture risk prediction sensitivity.

The invention relates to the field of disease animal model construction, and particularly discloses a postmenopausal osteoporosis and knee osteoarthritis co-disease animal model construction method which comprises the following steps: selecting a female animal as an experimental subject; the selected female animals are injected with a GnRH agonist, meanwhile, low-calcium feed feeding and oxidative stress stimulation are conducted, and feeding is conducted for a preset time; detecting bone mineral density and bone trabecula parameters of the fed female animals, and screening qualified female animals meeting set standards; performing meniscus tearing operation on the qualified female animal, and implanting sustained release microspheres loaded with inflammatory factors at the torn part during the operation; carrying out weight-bearing training on the female animal after the operation, and continuing for a set time length; and performing health detection on the female animals at different time points. According to the method, through multi-factor collaborative induction of the PMOP, minimally invasive construction of the KOA and multi-dimensional health detection, accurate simulation of a co-disease pathological process and clinical characteristics is realized, and the authenticity and stability of the model are improved.

The invention provides an application of narirutin in preparation of a medicine for preventing and / or treating osteoclast of inflammatory arthritis, relates to the technical field of biomedicine, and adopts a collagen-induced mouse arthritis model to observe the treatment effect of the narirutin on the osteoclast of the inflammatory arthritis. The arthritis activity degree of the mouse is analyzed through general claw photographing, thickness measurement, near-infrared temperature measurement and a claw imprinting experiment, three-dimensional reconstruction and bone trabecula analysis are carried out on local joints and the whole body bone mass of the mouse through micro-CT scanning, and Hamp is applied; e, dyeing and Famp; through histological staining analysis such as O staining and TRAP staining, in combination with immunohistochemical staining and the like, the narirutin is proved to play a role in treating inflammatory arthritis, inhibit macrophage pro-inflammatory M1 type polarization, relieve the inflammation level, improve the bone mass of local joints and the whole body, and further improve bone destruction in inflammatory arthritis diseases. The narirutin provides a new way for medicine prevention and treatment of inflammatory arthritis.

The invention discloses a titanium-magnesium hollow screw system capable of promoting fracture healing and a manufacturing method. The titanium-magnesium hollow screw system comprises a titanium-based supporting structure and a magnesium filling layer. The titanium-based supporting structure comprises a main body part, the surface of the main body part is provided with an imitated bone trabecula part, and a plurality of bone gaps are formed in the imitated bone trabecula part; wherein bone gaps are filled with the magnesium filling layer, and the magnesium filling layer is combined with the titanium-based supporting structure in a physical embedding mode; the titanium-based supporting structure bears and maintains initial fixation and long-term bearing, so that the strength and the stability of the screw are ensured; the surface imitated bone trabecula and the communicated bone gaps increase the surface area and provide a physical channel for vascularization and bone tissue ingrowth, so that synostosis is promoted; the magnesium filling layer releases magnesium ions after being locally controllably degraded, so that osteogenesis and angiogenesis are favorably stimulated, the local biological environment is improved, instant mechanical support after an operation is ensured, bone healing is promoted through local biological activity release and structural orientation, the healing time is favorably shortened, and the healing quality is favorably improved.

The utility model relates to the technical field of medical instruments, and discloses a high-stability durable tibial prosthesis which comprises a locking mechanism, the locking mechanism is of a double-layer structure, an anti-rotation mechanism is rotatably arranged on the lower end face of the locking mechanism, a telescopic mechanism is movably arranged on the lower end face of the anti-rotation mechanism, and an implanting mechanism is fixedly arranged on the lower end face of the telescopic mechanism. The locking mechanism comprises a locking hole, a side wing steel plate, a tibial plateau, a bone trabecula porous structure, a locking bone screw, a first suture hole and a second suture hole, the anti-rotation mechanism comprises an anti-rotation block, an anti-rotation groove, a first cylindrical pin and an anti-rotation rod, and the telescopic mechanism comprises a telescopic handle, a second through hole, a second cylindrical pin, an adjusting button and an adjusting shaft. The implanting mechanism comprises an intramedullary nail and a bone cement groove. According to the bone trabecula prosthesis, the retraction mechanism is arranged and can be adjusted according to the requirements of different patients, and the bone trabecula porous structure and the anti-rotation mechanism are arranged, so that the prosthesis can be kept stable.

The invention provides application of linariin-6-O-glucoside in preparation of a product for preventing and treating osteoporosis, and relates to the field of biological medicine. According to the invention, dyeing experiments of alkaline phosphatase, alizarin red and tartaric acid resistant acid phosphatase prove that the sesaminin-6-O-glucoside has affinity for FPPS receptors, has the capability of promoting bone marrow mesenchymal stem cells to form bone cells, is superior to that of bisphosphate, and can inhibit the generation of osteoclasts; microCT (micro computed tomography) detection results show that the sesaminin-6-O-glucoside has the effect of relieving the osteoporosis and can promote the formation of bone trabecula. According to the application disclosed by the invention, it is proved for the first time that the sesaminin-6-O-glucoside has the effect of resisting osteoclast formation, and meanwhile, the sesaminin-6-O-glucoside also has a better osteogenesis effect, so that a basis is provided for developing the sesaminin-6-O-glucoside as a potential medicine for treating osteoporosis.

CT images from the neck, lung, cardiac, abdominal, pelvis, hip, spine or lower extremity areas are obtained and analyzed by a computer to measure trabecular bone density on each level it is available, in the spine and hip. Any bone tissue associated with vertebrae that is fractured is excluded, along with Schmorl's nodes, large blood vessels, and cortical bone, to accurately average the trabecular bone density on a scan. The density of fat, heart, and muscle tissue of a subject is used to calibrate the results. That data may be input to an absolute fracture risk model (Fracture Risk Algorithm calculator). Information such as bone density, T score, Z score, fracture risk, and identification of vertebral fractures (if present) may be determined and reported.

The invention relates to the field of biological medicine, in particular to application of myeloid-derived suppressor cell-derived vesicles in preparation of a medicine for relieving osteoporosis. The bone resorption-resistant drug is entrapped by the myeloid-derived suppressor cell-derived vesicles and is delivered to the myeloid-derived suppressor cells, so that the targeting property of the bone resorption-resistant drug is improved, and bone resorption is inhibited by inhibiting the activity of osteoclasts and the absorption effect of the osteoclasts on bone trabecula; the proportion of abnormal myeloid-derived suppressor cell subgroups in bone marrow can be reduced, formation and activity of osteoclasts are indirectly inhibited, the bone resorption process is further slowed down, and the curative effect of the anti-bone resorption medicine on osteoporosis can be improved.

The invention discloses a method for preparing a phosphorylated salmon collagen peptide-calcium chelate by taking salmon collagen peptide as a raw material, preparing high-calcium binding active peptide (P-CP) through phosphorylation modification and chelating the high-calcium binding active peptide with calcium ions. The method comprises the following steps: (1) enzymolysis preparation of salmon bone collagen; (2) phosphorylation modification of a peptide fragment mediated by sodium tripolyphosphate; and (3) optimizing a calcium ion chelation process. The chelating rate of the obtained P-CP-Ca calcium reaches 91.21%, and structural characterization proves that a phosphate group (PO4 < 2->) is combined with calcium ions through ionic bonds. Animal experiments show that P-CP-Ca can significantly improve the serum calcium level of a calcium-deficiency mouse (the H group recovers to a normal range), reduce the activity of a bone resorption marker TRAP (Target Related Amplified Protein) (which is 25.4% lower than that of a model group), and improve the bone trabecula microstructure (the bone mineral density is improved by 32.7%). The invention provides a new technology for valuable utilization of fishery by-products and development of functional calcium supplements.

The invention belongs to the technical field of medicines, and particularly relates to application of lycium barbarum glycopeptide in preparation of a medicine for preventing or treating senile ossification. The experimental results show that the wolfberry glycopeptide can improve the posterior limb movement ability and the bone trabecula condition of old mice by increasing the femoral hardness, relieving the bone tissue calcium loss condition, improving the bone formation rate, promoting osteoblasts and inhibiting osteoclasts, so that the effect of treating bone aging is achieved. As a traditional Chinese medicinal material extraction product, the lycium barbarum glycopeptide can be effectively used for preventing and treating senile ossification, has the prospect of being developed into the medicine for preventing and treating senile ossification, provides more treatment choices for clinically preventing or treating senile ossification, and has important social benefits and economic values.

The utility model belongs to the technical field of orthopedic implants, and particularly relates to a porous bone grafting-free window type interbody fusion cage. The multi-hole type bone grafting window-free interbody fusion cage comprises a frame body which comprises four side faces and two end faces, and the four side faces are of hollow structures; the space defined by the frame body is filled with the porous structure body; the meshing teeth are arranged on the upper surface and the lower surface of the frame body; and the clamping structure is arranged at one end part of the frame body. According to the multi-hole type bone grafting-free window type interbody fusion cage, due to the design of the bone grafting-free window, the complexity of the using process is reduced, the operation is convenient, and the possibility that the fusion cage is polluted is reduced; the porous structure body with the bionic bone trabecula can be printed through 3D printing, and pore channels for bone tissue to grow in and a surface beneficial to cell adhesion can be effectively provided; the hydroxyapatite coating improves the biological activity of the surface of the base material and enhances the interface integration of the interbody fusion cage and the upper and lower end plates of the vertebral body.

The invention provides a bone evaluation method based on neural network enhancement and finite element analysis. The bone evaluation method comprises the following steps: acquiring an ultrahigh-resolution CT image of a living vertebra; performing domain conversion processing on the CT image by adopting a generative neural network; carrying out resampling and segmentation on the enhanced CT image; constructing a bone trabecula microstructure model in the cancellous bone mask area; assembling the RVE unit and the cortical bone model into a complete vertebral finite element model, and applying a multi-working-condition load to the RVE unit to calculate anisotropic material parameters; and carrying out axial compression finite element analysis on the complete centrum model, and judging the bone health state. According to the method, information of two dimensions of bone mass and bone, especially contribution of a bone trabecula microstructure to bone strength, is comprehensively considered, bone degeneration and fracture high-risk patients can be recognized earlier, and a scientific basis is provided for clinical early intervention.

The invention discloses a bone trabecular bionic implant, and relates to the field of bone trabecular bionic planting, the bone trabecular bionic implant comprises a bone trabecular bionic body, the lower end of the bone trabecular bionic body is fixedly connected with a fixed threaded part, and a reserved filling cavity is formed in the bone trabecular bionic body; an external threaded piece is arranged at the lower end of the bone trabecula bionic body. According to the bone trabecular bionic implant, the whole bone trabecular bionic body is made of a tantalum metal material, the tantalum metal has bone healing force and supporting strength, and the surface of the bone trabecular bionic body is of a porous structure, so that attachment and ingrowth of muscle fulcrums are facilitated, fulcrums are provided for long-term stability of nodules and muscles, exertion of muscle force is facilitated, and the bone trabecular bionic implant has a good application prospect. The bone trabecula bionic body is filled with gel biological factor substances through a reserved filling cavity, the bone trabecula bionic body is mainly applied to implant operation after femoral head necrosis in early and middle stages and drilling decompression, and other drugs can be plugged into micropores in the surface of the bone trabecula bionic body and are slowly released.

The present disclosure discloses a tibial plateau prosthesis with trabeculae containing zirconium-niobium alloy on oxidation layer and a preparation method thereof. The preparation method uses zirconium niobium alloy powder as raw material, conducting a 3D printing for one-piece molding to obtain an intermediate product of the tibial plateau, performing hot isostatic pressing and cryogenic oxidation to obtain the tibial plateau prosthesis comprising a proximal trabecular layer and a distal trabecular layer; the pore size and porosity of the proximal trabecular layer are evenly arranged, and the distal trabecular layer are partitioned; the topological structure of the trabeculae of the tibial plateau prosthesis is gradiently distributed from three dimensions; the micro-strain in the 64%-72% region of the finite element model of the tibial plateau bone tissue is between the minimum effective strain threshold and the supraphysiological strain threshold, which increases the mechanical adaptation of the prosthesis.

The present application relates to a kind of trabecula-cement composite finite element model construction method, method includes obtaining trabecula microimage data;Reconstruct the three-dimensional structure of trabecula in the region of interest;The trabecula in the three-dimensional structure image of trabecula is polished and smoothed;Convert to entity after being wrapped using fluid domain;Two-dimensional surface mesh subdivision is carried out to fluid domain, and three-dimensional body mesh division is carried out after subdivision to fluid domain;Trabecula is divided into three-dimensional body mesh;With fluid domain as cement, obtain the trabecula-cement composite of preset filling depth, respectively give cement, trabecula grid corresponding material attribute and material parameter, set boundary condition, load and the contact type between cement and trabecula, obtain trabecula-cement composite finite element model.The method of the present application omits the process of traditional construction trabecula-cement composite sample, and the finite element model established is high in accuracy, low in cost and easy to popularize.

The present application relates to a kind of biomimetic reticular nanofiber composite coating and its preparation method and infectious bone defect repair application, belong to biomedical material field.The present application is aimed at solving the technical problem of the poor bone integration of implant in infectious bone defect.The present application provides a kind of biomimetic reticular nanofiber composite coating, which is formed by layer-by-layer self-assembly on the surface of implant by lysozyme amyloid fiber and polyphenols (such as tannin etc.) Form reticular structure, then prepared with bioactive metal ions coordination;The number of coating layers is 4-8 layers.Preparation method includes lysozyme fiberization, alternate deposition and ion loading steps.The composite coating of the present application has broad-spectrum antibacterial, antioxidant stress and promotes osteogenesis function;In animal model, bacterial load is reduced by 80%, bone volume fraction and trabecular bone parameters are significantly improved, and can realize anti-bacterial biofilm infection-antioxidant stress-angiogenesis-promote bone regeneration synergy.

The present disclosure discloses a zonal trabecular femoral condylar component containing zirconium-niobium alloy with an oxidation layer and a preparation method thereof. The preparation method is as follows: using zirconium-niobium alloy powder as a raw material, conducting a 3D printing for one-piece molding, and obtaining intermediate products of the zonal trabecular femoral condylar component containing zirconium-niobium alloy with the oxidation layer, after Sinter-HIP, cryogenic cooling and surface oxidation, the zonal trabecular femoral condylar component containing zirconium-niobium alloy with the oxidation layer is prepared. Partial of the zonal trabecular femoral condylar component containing zirconium-niobium alloy with the oxidation layer is provided with Zonal trabecula.

The present application belongs to the field of foot and ankle surgical implant devices and biomedical material surface engineering technology, and discloses a tibial component of ankle prosthesis with a composite coating, which comprises: a metal substrate which is a bionic trabecular three-dimensional interconnected porous titanium alloy structure, the porosity is 50-80%, the average pore size is 400-900 mu m, and the connected porosity is greater than or equal to 85%, so that the elastic modulus is controlled in the range of 5-20 GPa, and is matched with the cancellous bone of the tibia; a composite functional coating is in situ grown on the surface of the metal substrate, and the composite functional coating comprises a bioactive layer and a functional ion doped layer. The tibial component of the present application comprises a porous titanium alloy metal substrate and a composite functional coating constructed in situ on the surface thereof, the porous titanium alloy substrate is designed in a bionic trabecular structure to form a three-dimensional interconnected porous structure, so as to provide an elastic modulus matched with the cancellous bone of the tibia and promote the growth of bone tissue.

This invention discloses a composition with bone-health-promoting functions and its applications, belonging to the field of microbial engineering. The composition comprises milk calcium, colostrum basic protein, and Bifidobacterium breve i1088 powder. The composition provided by this invention, which has a synergistic effect between milk calcium, colostrum basic protein, and Bifidobacterium breve i1088 powder, enhances the conversion rate of calcium from the blood to bone through the action of probiotics, thereby improving the actual utilization rate of calcium and effectively promoting bone health. Experimental data show that this composition significantly increases bone mineral density, bone volume fraction, and trabecular thickness in a female rat osteoporosis model, and significantly reduces trabecular spacing in the same model. The composition provided by this invention is suitable for promoting bone health and preventing and / or improving osteoporosis.

The invention provides an implicit porous structure modeling method based on Voronoi subdivision, and relates to the technical field of implicit modeling. The method comprises the following steps: firstly, carrying out Voronoi space subdivision on a point set to generate a three-dimensional cell structure; constructing an internally tangent implicit field based on the surface normal and vertex coordinates; constructing a surface-level connected implicit field according to a surface-adjacency relationship, and further fusing to generate a unit-level implicit field; fusing all the unit fields to obtain a global implicit field, and extracting a contour surface to generate a porous structure. By adjusting control parameters, high-precision controllable modeling of the pore structure is achieved, and the method is suitable for bone trabecula structure matching.

The invention provides a method for predicting spinal refracture of an OVCF patient based on an X-ray image. According to the method, a multi-scale space-time convolutional neural network is adopted to analyze a standardized thoracolumbar spine X-ray image sequence, a vertebral body morphology analysis module, a microstructure texture feature extraction module and a time sequence dynamic modeling module are integrated, and the vertebral body morphology analysis module is used for extracting vertebral body geometric morphology features including the height ratio relation of the front edge, the center and the rear edge; the microstructure texture feature extraction module adopts a multi-direction Gabor filter combination and a local binary mode operator to extract the directivity, density and connectivity features of the bone trabecula; the time sequence dynamic modeling module adopts a hybrid architecture of combining a three-dimensional convolutional neural network with a long-short-term memory network; the system further comprises inter-vertebral-body relevance modeling. According to the method, a multi-task loss function item is adopted for joint optimization. According to the method, the prediction accuracy reaches 92.6%, patients can be divided into three risk levels, and effective decision support is provided for clinical precise prevention and treatment.

The invention discloses an additive-manufactured biological tibia tray prosthesis and a manufacturing method thereof, and relates to the technical field of artificial knee joint prostheses. The biological type tibia support prosthesis comprises four types: a biological type symmetrical tibia support, a biological type symmetrical stemless tibia support, a biological type anatomical tibia support and a biological type anatomical stemless tibia support. The prosthesis mainly comprises a support body, a porous structure, a plug pin and the like, and is integrally formed through an additive manufacturing technology, so that the precision and the strength are ensured. The porous structure is designed to be in an irregular space three-dimensional grid shape, the thickness ranges from 0.6 mm to 1.6 mm, and the porous structure is used for promoting bone trabecula ingrowth and achieving biological fixation. The positioning nail adopts a bullet-shaped design and is provided with an exhaust groove and a notch, so that the installation is simplified and the stability is enhanced. The manufacturing method comprises the steps of design modeling, stress optimization, additive manufacturing and aftertreatment, and the prosthesis is made of a titanium alloy material and meets related international standards. The invention has the advantages of simple installation, reliable fixation, good bone ingrowth effect and the like.

The embodiment of the invention provides a bone evaluation model training method and device and a storage medium. In the embodiment of the invention, a plurality of CT images obtained by scanning a target skeleton of a living object through high-resolution CT equipment are acquired, and the enhanced images are input into an unsupervised clustering algorithm to complete voxel-level segmentation of the bone microstructure through global contrast enhancement and local contrast enhancement of the bone microstructure and a background region. Based on the segmentation result, bone microstructure images are extracted to construct a training sample set, and an attention mechanism is utilized to construct an initial model structure for supervised training, so that a bone evaluation model is obtained. According to the method, the problem of manual labeling is solved by utilizing an unsupervised method, so that bone microstructure segmentation can be efficiently and automatically completed, the recognition accuracy and efficiency of microstructures such as bone trabecula and the like are improved, quantitative analysis on the bone microstructure under a high-resolution CT imaging condition is realized by virtue of supervised model training, and the reliability of bone quality evaluation is improved.

The present disclosure discloses an osteoporosis treatment system, apparatus, and method. According to the present disclosure, the osteoporosis treatment system includes: a solid gel pad that has a groove formed to be inclined in consideration of a main direction of trabeculae for an osteoporosis treatment area of a patient obtained using an imaging device; and a fixing part that fixes the solid gel pad to skins near treatment areas of each patient, wherein a probe of low-intensity pulsed ultrasound is inserted into the groove of the solid gel pad so that pulsed ultrasound applied by the low-intensity pulsed ultrasound amplifies movement of fluid inside a trabecular bone to maximize a response of osteoblasts distributed on a surface of the trabeculae.

The invention relates to application of a TRMT10C agonist TM3 in preparation of a medicine for treating senile osteoporosis, and belongs to the technical field of biological medicines. According to the invention, the TRMT10C agonist TM3 is used for treating senile osteoporosis for the first time. A mouse experiment verifies that the TRMT10C agonist TM3 can inhibit bone loss of a mouse with osteoporosis, increase the bone density, the number of bone trabecula and the volume fraction of the bone trabecula, reduce the separation degree of the bone trabecula and promote bone formation. It is fully proved that the TRMT10C agonist TM3 can be used for treating the senile osteoporosis caused by the fact that the osteogenesis rate is remarkably reduced due to age increase, and therefore the TRMT10C agonist TM3 can be used for preparing the medicine for treating the senile osteoporosis and has important significance in clinical treatment of the senile osteoporosis in the future.

The invention discloses an application of 6-CEPN in preparation of a product for preventing and improving osteoporosis. According to the invention, ovariectomized mice are fed with two doses of 6-CEPN, which discovers that the 6-CEPN can obviously inhibit abnormal weight increase of the mice caused by estrogen decrease and can also improve bone microstructure of the ovariectomized mice; the bone trabecula network structure is adjusted by increasing the bone trabecula connection density, the bone trabecula number and the bone trabecula thickness and reducing the separation degree of the bone trabecula, meanwhile, 6-CEPN can further increase the bone density and the bone volume fraction of ovariectomized mice, increase the rigidity and deflection of bones and improve the bone strength, the effect of high-dose 6-CEPN is larger than that of low-dose 6-CEPN, and the effect of high-dose 6-CEPN is better than that of low-dose 6-CEPN. Therefore, the composition has a dose-dependent effect.