Preparation method of porous titanium-alloy femoral head support rod in bionic bone trabecula structure

A trabecular structure and support rod technology, which is applied in the fields of femoral head, medical science, hip joint, etc., can solve the problems of increased risk of fractures at the base of the greater trochanter, reduce the occurrence of rod loosening, achieve slow-release effects, Favorable effect of bone tissue ingrowth

Active Publication Date: 2015-05-27
维度(西安)生物医疗科技有限公司
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In addition, some literatures reported that the risk of fracture of the base of

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  • Preparation method of porous titanium-alloy femoral head support rod in bionic bone trabecula structure
  • Preparation method of porous titanium-alloy femoral head support rod in bionic bone trabecula structure
  • Preparation method of porous titanium-alloy femoral head support rod in bionic bone trabecula structure

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Embodiment Construction

[0030] The present invention will be further described in detail below in conjunction with the drawings.

[0031] The preparation method of the present invention is as follows:

[0032] 1) First, construct a three-dimensional model of a bionic support rod with a bionic bone trabecular structure with the internal cancellous bone structure of the human femoral head;

[0033] 2) Secondly, select Ti6Al4V or Ti2448 spherical powder with a particle size of less than 45μm, and use Selective Laser Melting (SLM) or Electron Beam Melting (EBM) technology to print out the three-dimensional model of the bionic support rod. Support rod

[0034] 3) After printing, the support rods are ultrasonically cleaned for 10 minutes in the order of acetone, alcohol, and distilled water, and then dried. Cobalt 60 radiation sterilization, and nitric acid, hydrofluoric acid and water are mixed in a molar ratio of 1:4:5. Obtain an acid mixture, and place the support rod in the acid mixture to erode the rod body ...

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Abstract

The invention relates to a preparation method of a porous titanium-alloy femoral head support rod in a bionic bone trabecula structure. The support rod is prepared from titanium alloy powder by printing by adopting an SLM (selective laser melting) or EBM (electron beam melting) technology, wherein the titanium alloy powder serves as a raw material, has low modulus of elasticity and has a particle size of less than 45mu m. The structure of the support rod structure is similar to that of the human cancellous femoral neck bone trabecula so that the modulus of elasticity of the support rod is made to be similar to that of the human femoral neck as much as possible and the phenomenon that the support rod becomes loose can be reduced effectively. In addition, the surface of the support rod is provided with a poly(lactic-co-glycolic acid (PLGA) nanoparticle, bone morphogenetic protein-2 (BMP-2) and a vascular endothelial growth factor (VEGF) complex so that a growth factor slow-release effect can be achieved and the bone tissue can grow into the support rod.

Description

Technical field [0001] The invention belongs to the field of medical devices, and specifically relates to a preparation method of a porous titanium alloy femoral head support rod with a bionic bone trabecular structure for treating human early femoral head necrosis and reducing the risk of early femoral head necrosis collapse. Background technique [0002] Femoral head necrosis usually occurs in young and middle-aged people aged 20-50. If they are not treated in time, they often progress to collapse of femoral head necrosis and have to undergo total hip replacement. At present, the service life of hip joint prostheses used in clinical practice is generally 15-20 years, and young and middle-aged people often face the problem of prosthesis revision after total hip replacement. Therefore, how to actively and effectively treat early femoral head necrosis, delay or avoid patients undergoing total hip replacement is a clinical problem currently facing. [0003] Common treatments for ear...

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Application Information

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IPC IPC(8): A61L27/56A61L27/54A61L27/18A61L27/06A61F2/36
Inventor 郭征王财儒吴智钢张涌泉
Owner 维度(西安)生物医疗科技有限公司
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