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Injectable expanded composite bone cement of bone-imitating trabecula structure and preparation method of injectable expanded composite bone cement

A technology of trabecular structure and bone cement, applied in medical science, tissue regeneration, prosthesis, etc., can solve the problems of heat generation, high elastic modulus, and difficult for cells to grow in.

Pending Publication Date: 2018-06-22
UNIV OF SCI & TECH BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] Based on the above discussion, in order to overcome the problems existing in the application of traditional bone cement, such as heat generation, high elastic modulus, volume shrinkage after curing, and difficulty in cell growth, etc.

Method used

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  • Injectable expanded composite bone cement of bone-imitating trabecula structure and preparation method of injectable expanded composite bone cement
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  • Injectable expanded composite bone cement of bone-imitating trabecula structure and preparation method of injectable expanded composite bone cement

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preparation example Construction

[0032] Such as Figure 1-Figure 3 As shown, the present invention provides an injectable expandable composite bone cement imitating a bone trabecular structure and a preparation method thereof. The injectable expandable bone cement has injectability, and can generate volume expansion during solidification and form a porous structure after solidification The high-quality bone cement can solve the problems of heat generation, high elastic modulus, volume shrinkage and other problems in the application of traditional bone cement, and it also has good biocompatibility and degradability.

[0033] Its preparation method is as follows:

[0034] Mix the powder material and the expansion material evenly in a certain proportion, add a certain amount of curing liquid, and stir quickly to form a slurry; inject the formed slurry into the mold, and put the mold into a constant temperature and humidity box to cure for a certain period of time; after the curing is completed Demoulding to obt...

Embodiment 1

[0047] The powder material of the injectable expandable bone cement of the imitation bone trabecular structure of this embodiment is calcium sulfate hemihydrate powder with a volume fraction of 95%, and an expansion material with a volume fraction of 5%; the solidification liquid is deionized water, liquid-solid The ratio is 0.5 ml / g.

[0048] The expanded material in this implementation example is prepared according to the following steps: Mix polyvinyl alcohol with deionized water and stir to fully dissolve; The resulting polyvinyl alcohol solution is foamed to form bubbles of uniform size in the solution; Add crosslinking agent and catalyst to the foamed solution, and pour the solution into the mold; After molding, it is taken out from the mold, rinsed, dried and mechanically crushed into granules with a particle size of less than 1 mm.

[0049] The preparation steps of the injectable expansive bone cement imitating the bone trabecular structure are as follows:

[00...

Embodiment 2

[0054] The powder material of the injectable expandable bone cement of the imitation bone trabecular structure of this embodiment is calcium phosphate bone cement powder with a volume fraction of 90%, and an expansion material with a volume fraction of 10%; the solidification solution is a physiological saline solution, liquid-solid The ratio is 0.5 ml / g.

[0055] The expanded material in this implementation example is prepared according to the following steps: Mix polyvinyl alcohol with deionized water and stir to fully dissolve; The resulting polyvinyl alcohol solution is foamed to form bubbles of uniform size in the solution; Add crosslinking agent and catalyst to the foamed solution, and pour the solution into the mold; After molding, it is taken out from the mold, washed, dried and mechanically crushed into granules, and the particle size is less than 1 mm.

[0056] The preparation steps of the injectable expansive bone cement imitating the bone trabecular structur...

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Abstract

The invention provides injectable expanded composite bone cement of a bone-imitating trabecula structure and a preparation method of the injectable expanded composite bone cement. The composite bone cement is prepared from a powder material, a curing solution and an expanding material, wherein the powder material and the expanding material are uniformly mixed according to a certain ratio; the curing solution is added and is uniformly stirred to obtain composite bone cement slurry; the composite bone cement slurry is injected into a mold and is cured to obtain a composite bone cement cured body. The bone cement prepared by the method has good injection performance; in a condensation process, remarkable volume expansion can be generated; finally, a porous structure similar with a bone trabecula is formed in the bone cement; the injectable expanded composite bone cement has good biocompatibility, the growth of cells and tissues is facilitated and the cells have remarkable activity on theinjectable expanded composite bone cement. The method provided by the invention has a simple and convenient process and can be widely applied to field of bone repairing.

Description

technical field [0001] The invention belongs to the technical field of biomedical materials, and in particular relates to an injectable expandable composite bone cement imitating a bone trabecular structure and a preparation method thereof. Background technique [0002] The global trend of aging is increasing. At the same time, with the continuous improvement of disease diagnosis and treatment, rehabilitation and nursing, the life expectancy of the elderly population is getting longer and longer, and the proportion of the elderly population will become higher and higher. Osteoporotic vertebral compression fracture is a common osteoporotic brittle fracture that has become a common and frequently-occurring disease in the elderly. According to the "China White Paper on Osteoporosis Prevention and Control", new vertebral compression fractures occur every year in my country. As high as 1.81 million cases. The most prominent clinical symptom of vertebral compression fractures is...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/46A61L27/44A61L27/48A61L27/56
CPCA61L27/446A61L27/46A61L27/48A61L27/56A61L2430/02C08L29/04C08L33/12
Inventor 郑裕东王岩森杜红玉杨益鑫
Owner UNIV OF SCI & TECH BEIJING
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