Bionic design method of skull tissue engineering scaffold

A tissue engineering scaffold and design method technology, applied in bone implants, medical science, prostheses, etc., can solve problems such as inability to achieve pore connectivity, difficulty in forming biomaterials, and difficulty in ensuring connectivity.

Inactive Publication Date: 2013-03-20
TIANJIN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, it is difficult to form biomaterials, the shape distribution of internal pores cannot be controlled, and the connectivity is difficult to guarantee.
see image 3 , some scholars also generate various regular pore units by C...

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  • Bionic design method of skull tissue engineering scaffold
  • Bionic design method of skull tissue engineering scaffold
  • Bionic design method of skull tissue engineering scaffold

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Embodiment Construction

[0048] In order to make the objectives, technical solutions, and advantages of the present invention clearer, the following describes the embodiments of the present invention in further detail.

[0049] In view of the various deficiencies of the clinical repair methods of the skull defect, the application of bone tissue engineering to the clinic is urgently requested. The problem to be solved in the design of the skull scaffold is how to construct a microscopic simulation structure with mutual conduction. See Figure 20 In the present invention, by measuring the CT image of natural air-dried skull tissue, the corresponding algorithm is proposed to carry out the bionic design of the defected skull tissue engineering scaffold structure. This is of great significance for accelerating the clinical application of skull tissue engineering repair. There is no report on the bionic design of skull defects based on micro-CT technology.

[0050] 101: Perform three-dimensional reconstruction ...

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Abstract

The invention discloses a bionic design method of a skull tissue engineering scaffold, which comprises the following steps of: implementing three-dimensional reconstruction according to naturally aired skull micro CT (computed tomography) data to obtain a skull sample three-dimensional model; implementing statistics and analysis for the skull sample three-dimensional model to build a skull microporous structure parametric model; implementing skull scaffold bionic design through the skull microporous structure parametric model; and generating a bionic scaffold. Based on measurement of a natural skull micro CT image, the method raises three elements of a space network architecture, a cavity and a connection tube to implement the bionic design for the scaffold; an obtained internal microporous architecture is similar to a bone trabecula of a natural skull, and the average hole scale is about 500-700 microns, so that bone cell growth and climbing demands are satisfied; and moreover, the skull scaffold, obtained by intersection operation with a patch model of a coloboma part, can be matched with an adjacent part, so that the communication among holes is realized, and a bone structure of a true skull is suited better.

Description

Technical field [0001] The invention relates to a bionic design of a scaffold, in particular to a bionic design method of a skull tissue engineering scaffold. Background technique [0002] See figure 1 , Skull defects caused by injuries, tumors and congenital bone abnormalities can cause changes in intracranial pressure, localized hydrocephalus, brain atrophy, and epilepsy. The current clinical treatment of neurosurgery is mainly to perform skull repair. There are three ways of autologous bone transplantation, allogeneic or xenogeneic bone transplantation and allogeneic bone replacement material transplantation. Autologous bone is considered to be the most ideal bone graft material. However, the source of bone tissue of autologous bone is very limited; allogeneic or xenogeneic bone transplantation has the risk of spreading the source of disease and may produce rejection reactions; see figure 2 , Allogeneic bone substitute materials, such as stainless steel mesh, titanium mesh, s...

Claims

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Application Information

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IPC IPC(8): A61F2/28
CPCA61F2/28A61F2002/30001
Inventor 郑淑贤李佳
Owner TIANJIN UNIV
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