Bionic design method of skull tissue engineering scaffold

Abstract

The invention discloses a bionic design method of a skull tissue engineering scaffold, which comprises the following steps of: implementing three-dimensional reconstruction according to naturally aired skull micro CT (computed tomography) data to obtain a skull sample three-dimensional model; implementing statistics and analysis for the skull sample three-dimensional model to build a skull microporous structure parametric model; implementing skull scaffold bionic design through the skull microporous structure parametric model; and generating a bionic scaffold. Based on measurement of a natural skull micro CT image, the method raises three elements of a space network architecture, a cavity and a connection tube to implement the bionic design for the scaffold; an obtained internal microporous architecture is similar to a bone trabecula of a natural skull, and the average hole scale is about 500-700 microns, so that bone cell growth and climbing demands are satisfied; and moreover, the skull scaffold, obtained by intersection operation with a patch model of a coloboma part, can be matched with an adjacent part, so that the communication among holes is realized, and a bone structure of a true skull is suited better.

Description

Technical field [0001] The invention relates to a bionic design of a scaffold, in particular to a bionic design method of a skull tissue engineering scaffold. Background technique [0002] See figure 1 , Skull defects caused by injuries, tumors and congenital bone abnormalities can cause changes in intracranial pressure, localized hydrocephalus, brain atrophy, and epilepsy. The current clinical treatment of neurosurgery is mainly to perform skull repair. There are three ways of autologous bone transplantation, allogeneic or xenogeneic bone transplantation and allogeneic bone replacement material transplantation. Autologous bone is considered to be the most ideal bone graft material. However, the source of bone tissue of autologous bone is very limited; allogeneic or xenogeneic bone transplantation has the risk of spreading the source of disease and may produce rejection reactions; see figure 2 , Allogeneic bone substitute materials, such as stainless steel mesh, titanium mesh, s...

AI Technical Summary

Problems solved by technology

However, it is difficult to form biomaterials, the shape distribution of internal pores cannot be controlled, and the connectivity is difficult to guarantee.

see image 3 , some scholars also generate various regular pore units by CAD method, such as: orthogonal type, radial type and honeycomb type, etc. Although they have good porosity, they cannot achieve good connectivity between pores, which is not conducive Ingrowth of cells and exchange of interstitial fluid

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