The invention discloses multifunctional inverted conical sterilization equipment which comprises an upright sterilization cylinder, a tubular condenser, a circulation pump, a water collecting tank A, a plate type condenser, a buffer tank, a vacuum pump and a water collecting tank B, wherein the upright sterilization cylinder comprises a cylinder body, a fly-cutter device, an ozone inlet hole, a discharge valve, a cylinder body water discharge hole, multi-stage spiral stirring paddles, a temperature sensor, a bucket cover water discharge hole, an ozone discharge hole, an air outlet, a speed reducer, a top spraying hole, a feeding hole and an interlayer steam inlet. The invention further discloses a sterilization process which comprises a high-temperature steam sterilization process, a low-temperature alcohol sterilization process, a normal-temperature ozone sterilization process and a material drying operation process. As the multi-stage spiral stirring paddles are arranged inside the cylinder and can rotate freely, materials can be uniformly mixed, and can be prevented from being caked or agglomerated due to the fly-cutter device, organic solvents can be recycled and circulated in the sterilization process, steam or hot water can be simultaneously introduced through the cylinder interlayer and the stirring paddle interlayer, then the materials can be sufficiently heated, the temperature can be preserved, and the multifunctional inverted conical sterilization equipment is large in temperature adjustment amplitude range and applicable to different sterilization or heating temperature requirements.