Electrochemical catalytic synthesis method of alpha-carbonyl ketone compounds

Abstract

The invention discloses an electrochemical catalytic synthesis method of alpha-carbonyl ketone compounds, and belongs to the technical field of preparation of alpha-carbonyl ketone compounds. The electrochemical catalytic synthesis method comprises the following steps: in a single-chamber electrolytic cell, in a certain amount of electrolyte solution, with alpha-carbonyl ketone as a raw material and halide as a catalyst, performing constant-current electrolysis at a certain temperature and a certain current density to obtain the alpha-carbonyl ketone compounds. Compared with the existing other electrochemical methods for synthesizing the alpha-carbonyl ketone compounds, the electrochemical catalytic synthesis method provided by the invention has the advantages as follows: the single-chamber electrolytic cell and an inexpensive electrode material are used, and an oxidant is regenerated by an electrochemical method; supporting electrolyte is not added, and only a catalytic amount of halide is taken as the catalyst, so that the cost is greatly reduced and the posttreatment is simple; therefore, the electrochemical catalytic synthesis method is more convenient for industrial production.

Description

technical field [0001] The invention relates to an electrochemical catalytic synthesis method of α-carbonyl ketone compounds, belonging to the technical field of preparation of α-carbonyl ketone compounds. Background technique [0002] α-Carbonyl ketones are important solvents, reaction intermediates or chemical reagents. In addition, many α-carbonyl ketones are also widely used as fragrances. For example, 3,4-hexanedione has a buttery aroma, and diacetyl has a creamy aroma. They are widely used in the production of cream, cheese, chocolate, candy, jelly and pudding. Therefore, the efficient use of α-carbonyl ketones Synthesis is in the spotlight. [0003] The electrochemical oxidation of α-hydroxy ketones is one of the ways to synthesize these compounds. Torii (Inokuchi, T.; Matsumoto, S.; Torii, S.J.Org.Chem.1991,56,2416) etc. in sodium bromide and N-oxo-2,2,6,6-tetramethylpiperidinium In the presence of the double catalyst composed, benzil was prepared by constant cur...

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Problems solved by technology

[0004] (1) Although Torii and Wang Jiangmei used a simple single-chamber electrolytic cell for electrolytic synthesis, the types of α-hydroxy ketones synthesized were limited, and it was necessary to use a complex dual-catalyst system or to regenerate the catalyst by adding an oxidant, which increased the reaction cost and post-processing complexity

[0005] (2) Nishiguchi found that the reaction cannot be carried out effectively in a single-chamber electrolytic cell, and a double-chamber electrolytic cell must be used, while using expensive metallic platinum as an electrode material

Compared with the single-chamber electrolytic cell, the use of the double-chamber electrolytic cell increases the cost of the equipment, increases the energy consumption, and the operation is more complicated

[0006] (3) The reaction solution cannot be recycled, resulting in a large discharge of high-concentration organic waste liquid

[0007] At present, in a single-chamber electrolytic cell, a single catalyst is used, and the preparation method of α-carbonyl ketone, which can be regenerated in situ and the reaction solution can be recycled, has not been reported in the literature at home and abroad.

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