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Medical titanium metal material and preparation method thereof

A technology of titanium metal and adhesion layer, which is applied in the field of surface modification of biomedical materials, can solve the problems of not being able to provide fixation and growth of osteoblasts, and achieve the goal of avoiding adhesion and reproduction, preventing shedding, and improving anti-bacterial adhesion ability Effect

Active Publication Date: 2015-02-04
嘉兴慧泉生物科技有限公司
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Problems solved by technology

However, the disadvantage of this modification method is that it cannot provide fixation and growth of osteoblasts on the surface of the material.

Method used

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  • Medical titanium metal material and preparation method thereof

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[0040] A method for preparing a medical titanium metal material, wherein the method comprises the following steps:

[0041]Step 1. Pretreatment: The surface of the titanium sheet was sequentially polished with silicon carbide sandpaper No. 600 to No. 1200, and then ultrasonicated with acetone, ethanol and distilled water for 30 minutes in sequence, and vacuum-dried at 80°C to obtain the processed product 1;

[0042] Step 2. Preparation of titanium metal nanotubes: In the anodic oxidation electrolyte, connect the product 1 to the anode of the power supply, use a platinum sheet electrode as the cathode, and slowly increase the anodic oxidation voltage to the final voltage at a rate of 1V / s. During the oxidation process The electrolyte has been electromagnetically stirred, and after the anodic oxidation treatment is completed, it is immediately rinsed with a large amount of distilled water and dried to obtain product 2, which is a titanium metal matrix with a nanotube structure fo...

Embodiment 1

[0051] 1. Product preparation

[0052] The surface of the titanium sheet was sequentially polished with silicon carbide sandpaper No. 600 to No. 1200, and then ultrasonicated with acetone, ethanol and distilled water for 30 minutes, and vacuum-dried at 80°C to obtain the processed product 1; in the anodic oxidation electrolyte, the product 1 was connected to To the anode of the power supply, the cathode uses a platinum sheet electrode, and the anodizing voltage is slowly increased to the final voltage at a rate of 1V / s. During the oxidation process, the electrolyte has been electromagnetically stirred. Product 2 was obtained; then product 2 was soaked in 5mmol 3-(trifluoromethyl) benzyl mercaptan, soaked for 24 hours, washed with distilled water, and dried to obtain product 3; Glycol methyl ether ester, 0.19 mmol polyethylene glycol methacrylate with a molecular weight of 600, 5 mmol CuCl 2 Add 30ml of water and 15ml of ethanol, stir evenly, add 1~5mL with a density of 2×10 ...

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Abstract

The present invention discloses a medical titanium metal material and a preparation method thereof, wherein the medical titanium metal material has functions of bacterial adhesion resistance and osteoblast growth promotion, and comprises a titanium metal nanotube substrate, a first adhesion layer and a second adhesion layer, wherein the first adhesion layer is a 3-(trifluoromethyl)benzyl mercaptan adhesion layer, the second adhesion layer is a polyethylene glycol compound adhesion layer, the two adhesion layers are introduced to improve the adhesion of the polyethylene glycol compound on the titanium metal surface, and the polyethylene glycol compound is adopted to improve the bacterial adhesion resistance of the titanium metal, such that the adhesion breeding of the bacteria on the titanium metal surface is avoided. According to the present invention, the molecular imprinting method is adopted during the introduction process of the polyethylene glycol compound adhesion layer, such that the titanium metal material has the function of effective identification on the osteoblast molecules, and the osteoblasts can easily perform fixed growth on the material surface.

Description

technical field [0001] The invention relates to the field of surface modification of biomedical materials, in particular to a medical titanium metal material and a preparation method thereof. technical background [0002] With the development of medical technology, medical titanium metal is widely used in the treatment of dentition defects, bone loss and other diseases due to its light weight and hard texture. Infection is prone to occur during such operations, which may lead to serious consequences such as heavy antibiotic treatment, removal of implants and even death. There are two reasons for this: the accumulation of bacterial plaque on the surface of the implant and the low resistance of the osseointegration interface of the implant. Therefore, it is necessary to improve the antibacterial performance and the function of promoting osteoblast growth of titanium metal materials. [0003] The growth of bacteria on the surface of the material is divided into three steps: f...

Claims

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Application Information

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IPC IPC(8): A61L27/34A61L27/06A61L27/50
Inventor 李培源苏炜霍丽妮陈睿
Owner 嘉兴慧泉生物科技有限公司
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