Medicine for preventing and treating colibacillosis of chickens and preparation method thereof

The technology for chicken Escherichia coli and medicine is applied in the field of medicine for preventing and treating chicken Escherichia coli and its preparation, and can solve the problems of Escherichia coli being prone to drug resistance, different clinical manifestations and epidemic characteristics, increasing difficulty of colibacillosis and the like

Inactive Publication Date: 2015-02-18
BEIJING UNIV OF AGRI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Different serotypes have different clinical manifestations and epidemic characteristics, and Escherichia coli is prone to drug resistance, which makes it more difficult to prevent and treat colibacillosis

Method used

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  • Medicine for preventing and treating colibacillosis of chickens and preparation method thereof
  • Medicine for preventing and treating colibacillosis of chickens and preparation method thereof
  • Medicine for preventing and treating colibacillosis of chickens and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Add 75g of Pulsatilla pulsatillae, 50g of Sophora flavescens, 50g of Patrinia, 25g of Magnolia officinalis, 50g of Tinglizi, and the above five herbs into water and decoct 3 times, adding 2500g of water each time for 2 hours each time, combining the decoction liquid, and filtering , stand overnight, filter the supernatant, concentrate under reduced pressure (0.08Mp, 80°C) to a relative density of 1.05-1.10 (50°C), let it cool, add ethanol to make the alcohol content to 60%, stand for 48h, filter Take the supernatant, recover ethanol until there is no alcohol smell, add 1.5g potassium sorbate, stir well, add water to adjust to 500mL, filter, fill, sterilize (116°C, 30min) to obtain solution 1.

Embodiment 2

[0020] Add 150g Pulsatilla radix, 100g Sophora flavescens, 100g Patrinia, 50g Magnolia Officinalis, 100g Tinglizi, and the above 5 herbs into water and decoct 3 times, adding 2500g of water each time, 2 hours each time, combine the decoction liquid, and filter , stand overnight, filter the supernatant, concentrate under reduced pressure (0.08Mp, 80°C) to a relative density of 1.05-1.10 (50°C), let it cool, add ethanol to make the alcohol content to 60%, stand for 48h, filter Take the supernatant, recover ethanol until there is no alcohol smell, add 2g potassium sorbate, stir well, add water to adjust to 1000mL, filter, fill, sterilize (116°C, 30min) to obtain solution 2.

Embodiment 3

[0022] Add 225g of Pulsatilla pulsatillae, 150g of Sophora flavescens, 150g of Patrinia, 75g of Magnolia officinalis, 150g of Tinglizi, and the above five herbs into water and decoct 3 times. , stand overnight, filter the supernatant, concentrate under reduced pressure (0.08Mp, 80°C) to a relative density of 1.05-1.10 (50°C), let it cool, add ethanol to make the alcohol content to 60%, stand for 48h, filter Take the supernatant, recover ethanol until there is no alcohol smell, add 2.5g potassium sorbate, stir well, add water to adjust to 1500mL, filter, fill, sterilize (116°C, 30min) to obtain solution 3.

[0023] Taking the solution obtained in Example 2 as an example to carry out the clinical trial of preventing and treating chicken colibacillosis

[0024] The purpose of this experiment is to observe the clinical curative effect of solution 2 on the artificial infection of pathogenic Escherichia coli in chickens, and to provide experimental basis for its development, clinica...

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Abstract

The invention provides a medicine for preventing and controlling colibacillosis of chickens and a preparation method thereof. The medicine is prepared from the following raw material medicines: Chinese pulsatilla roots, flavescent sophora roots, herba patriniae, cortex magnoliae officinalis and tansymustard seeds. The preparation method comprises the following steps: crushing the raw material medicines, adding auxiliary materials desired for shaping a preparation, and making various preparations suitable for clinical applications according to a conventional method of the medicine preparation. The medicine disclosed by the invention jointly has the functions of clearing heat, removing toxicity, cooling blood to stop diarrhea, lowering adverse-rising energy, relieving asthma and adjusting the stomach and intestines, has the efficacy of improving the immunity of organisms, and can effectively prevent and treat the colibacillosis of the chicken.

Description

technical field [0001] The invention relates to the field of veterinary medicine, in particular to a medicine for preventing and treating chicken E. coli and a preparation method thereof. Background technique [0002] Chicken colibacillosis is an acute, subacute and chronic bacterial infectious disease of chickens caused by pathogenic Escherichia coli. After the middle of the 20th century, with the rapid development of the chicken industry, the prevalence of chicken colibacillosis has become increasingly serious in various countries, and the disease has become the most important bacterial infectious disease in the chicken industry. [0003] Chicken colibacillosis can occur in chickens of various ages, and can cause acute sepsis, fibrinous pericarditis, fibrinous perihepatitis, air sacitis, granuloma, peritonitis, salpingitis, umbilical cord inflammation, ophthalmia, enteritis, etc. A variety of diseases can also cause hatching dead embryos and weak embryos, causing great ec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61P31/04A61P37/04
CPCA61K9/08A61K36/185A61K36/31A61K36/489A61K36/575A61K36/71A61K2300/00
Inventor 侯晓林刘风华李焕荣姚华李宏全孙耀贵许剑琴牛卫宁史雅然武言
Owner BEIJING UNIV OF AGRI
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