Microwave-assisted high-efficiency method for synthesizing 5-cyanouracil
A cyanuridine and microwave-assisted technology, which is applied in the field of microwave-assisted efficient synthesis of cyanide-containing uracil, can solve the problems of long reaction time, complicated operation, high raw material cost, etc., and achieve the effect of low cost, simple operation and high yield
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[0019] A method for microwave-assisted high-efficiency synthesis of 5-cyanuracil, consisting of the following steps:
[0020] Step 1: microwave 1-300mmol of urea, 1-300mmol of malononitrile and 10-80 mL of triethyl orthoformate at a microwave reaction temperature of 60°C-80°C, a microwave power of 500W, and normal pressure, and microwave for 8-20 minutes. Prepare dicyanide intermediate I;
[0021] The reaction equation is:
[0022] ;
[0023] Step 2: Filter the reaction system of step 1 to remove the remaining triethyl orthoformate, then dissolve the obtained solid in 5-50 mL of sodium ethoxide 1.0-2.0 mol / L solution, and microwave at a reaction temperature of 30-50°C and power 300W, under the condition of normal pressure, carry out radiation reaction for 30-50 minutes; add 0.1-0.5 g of activated carbon for decolorization, then acidify with 5-30mL of glacial acetic acid and filter the resulting precipitate to obtain intermediate II;
[0024] Step 3: Add 30-150mL of 2.5-3....
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