Water-soluble up-conversion nanoparticles and preparation method thereof

A nanoparticle, water-soluble technology, applied in the field of nanomaterials, can solve the problems of limited application, poor water solubility and biocompatibility, and achieve the effects of high luminous intensity, good water solubility and good application prospects.

Active Publication Date: 2015-02-25
NANTONG HUWANG PLASTIC SCI & TECH DEV CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of these methods obtain oil-soluble UCNPs, which have poor water solubility and biocompatibility, which limits

Method used

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  • Water-soluble up-conversion nanoparticles and preparation method thereof
  • Water-soluble up-conversion nanoparticles and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] 0.78mmol of Y (CF 3 COO) 3 , 0.2mmol of Yb (CF 3 COO) 3 , 0.02mmol of Er(CF 3 COO) 3 , 10mmol sodium fluoride (NaF) and 20ml organic solvent (10ml oleic acid OA + 10ml carbadecene ODE) were added to a 50mL three-necked flask and heated to 120°C, continuously fed with nitrogen protection and heated for 1h, then Raise the temperature to 320°C at a speed of 1°C / min and stir it magnetically for 1 hour, cool down to room temperature naturally, add absolute ethanol, centrifuge to obtain a precipitate, and then repeatedly wash with water and ethanol to finally obtain various Upconverting nanoparticles (UCNPs) in organic solvents.

[0026] Mix 1g / L of 5mL up-converting luminescent nanoparticles hexane dispersion solution with 0.6g / L of 5mL nitrosonium tetrafluoroborate NOBF 4The dichloromethane solution was mixed at room temperature, and the mixture was shaken gently until the UCNPs precipitated, then centrifuged, the supernatant was removed, and then redispersed in water...

Embodiment 2

[0029] 0.69mmol of Y (CF 3 COO) 3 , 0.3mmol of Yb (CF 3 COO) 3 , 0.01mmol of Er(CF 3 COO) 3 , 10mmol sodium fluoride (NaF) and 20ml organic solvent (10ml oleic acid OA + 10ml carbadecene ODE) were added to a 50mL three-necked flask and heated to 120°C, continuously fed with nitrogen protection and heated for 1h, then Raise the temperature to 320°C at a speed of 1°C / min and stir it magnetically for 1 hour, cool down to room temperature naturally, add absolute ethanol, centrifuge to obtain a precipitate, and then repeatedly wash with water and ethanol to finally obtain various Upconverting nanoparticles (UCNPs) in organic solvents.

[0030] Mix 2g / L of 5mL up-converting luminescent nanoparticles hexane dispersion solution with 0.3g / L of 5mL nitrosonium tetrafluoroborate NOBF 4 The dichloromethane solution was mixed at room temperature, and the mixture was shaken gently until the UCNPs precipitated, then centrifuged, the supernatant was removed, and then redispersed in wate...

Embodiment 3

[0032] 0.78mmol of Y (CF 3 COO) 3 , 0.2mmol of Yb (CF 3 COO) 3 , 0.02mmol of Tm (CF 3 COO) 3 , 10mmol sodium fluoride (NaF) and 20ml organic solvent (10ml oleic acid OA + 10ml carbadecene ODE) were added to a 50mL three-necked flask and heated to 120°C, continuously fed with nitrogen protection and heated for 1h, then Raise the temperature to 320°C at a speed of 1°C / min and stir it magnetically for 1 hour, cool down to room temperature naturally, add absolute ethanol, centrifuge to obtain a precipitate, and then repeatedly wash with water and ethanol to finally obtain various Upconverting nanoparticles (UCNPs) in organic solvents.

[0033] Mix 2g / L of 5mL up-converting luminescent nanoparticles hexane dispersion solution with 0.6g / L of 5mL nitrosonium tetrafluoroborate NOBF 4 The dichloromethane solution was mixed at room temperature, and the mixture was shaken gently until the UCNPs precipitated, then centrifuged, the supernatant was removed, and then redispersed in wat...

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Abstract

The invention discloses water-soluble up-conversion nanoparticles and a preparation method thereof. The preparation method includes steps of firstly adopting the high-temperature thermal decomposition method to synthesize up-conversion luminescent nanoparticles (UCNPs), adopting NOBF4 to treat the UCNPs for replacing oleic acid molecules on the surface of the UCNPs, finally subjecting the UCNPs to reaction with hydrophilic hyperbranched polymers to obtain the water-soluble up-conversion nanoparticles. The water-soluble up-conversion nanoparticles are good in water solubility and high in light intensity and provided with active groups such as amino, carboxyl and hydroxyl available for coupling biomacromolecules and have promising application prospect in bioimaging, fluorescent labelling, drug carriers and the like.

Description

technical field [0001] The invention relates to a water-soluble up-conversion nano particle and a preparation method thereof, belonging to the field of nano materials. Background technique [0002] Rare-earth up-conversion luminescent material Up-conversion (UC) is a luminescent material that emits visible light under near-infrared light excitation, which can convert long-wave radiation into short-wave radiation through a multi-photon mechanism. This material emits light against Stokes' law, so it is also called anti-Stokes' law luminescent material. UC luminescence is based on the transition between 4f electrons of rare earth elements. The luminescence process can be divided into three steps: ① matrix lattice absorbs excitation energy; ② matrix lattice transfers the absorbed excitation energy to excited ions to make them excited; ③ excited rare earth ions emit fluorescence and return to the matrix. There are four main types of upconversion processes: excited state absorpt...

Claims

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Application Information

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IPC IPC(8): C09K11/85C09K11/02
Inventor 赵兵
Owner NANTONG HUWANG PLASTIC SCI & TECH DEV CO LTD
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