Preparation method for manganese dioxide composite catalyst and synthetic method for 2-pyridylaldehyde

Abstract

The invention discloses a preparation method for manganese dioxide composite catalyst and a synthetic method for 2-pyridylaldehyde, and belongs to the field of organic synthesis. The preparation method comprises the following steps: firstly, loading potassium permanganate to acid-modified attapulgite to obtain MnO4<->-attapulgite; secondly, loading Fe3O4 to the MnO4<->-attapulgite by a coprecipitation method, and roasting to obtain the MnO2 composite catalyst with high catalytic activity. According to the preparation method, the catalytic advantages of MnO2 are successfully combined with the quick separation advantages of the attapulgite-Fe3O4 magnetic material, so that MnO2 in the catalyst can be recycled; when the MnO2 composite catalyst is used for preparing 2-pyridylaldehyde, the reaction yield is high, the conditions are mild, and the catalyst can be separated from reaction liquid through a magnetic sedimentation method and recycled after the reaction is finished. The preparation method has the advantages of little environmental pollution, low reaction cost and the like, and is suitable for industrialized application.

Description

technical field

[0001] The invention belongs to the field of organic synthesis, and in particular relates to a preparation method of a pharmaceutical intermediate, more specifically, a preparation method of a manganese dioxide composite catalyst and a synthesis method of 2-pyridinecarbaldehyde. Background technique

[0002] 2-Pyridinecarbaldehyde is an intermediate of the laxative bisacodyl (bisacody1), and is also widely used as a raw material for fine organic synthesis. There are many kinds of 2-pyridinecarbaldehyde synthesis routes reported in the literature, but they are mainly based on two different starting materials. Obtain 2-pyridine formaldehyde (Huang Shengtang, Huang Wenlong, Zhang Huibin. The improvement of 2-pyridine formaldehyde synthetic technique [J]. Chemical Reagent, 2005,27 (1): 58); - Oxidation, rearrangement, hydrolysis and then oxidation to prepare 2-pyridinecarbaldehyde (Shan Shiming, Yu Shuqin, Liao Hong, etc. Synthesis of 2-pyridinecarbaldehyde [J]....

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