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Identification method for twenty aconitine compounds in traditional Chinese medicinal composition preparation

A composition, aconitine technology, applied in the field of identification of active ingredients of traditional Chinese medicine, can solve problems such as ingredient reporting

Active Publication Date: 2015-03-18
HEBEI YILING MEDICINE INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the previous research on the active part components of this traditional Chinese medicine composition, there was no report on the detection of components in aconite

Method used

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  • Identification method for twenty aconitine compounds in traditional Chinese medicinal composition preparation
  • Identification method for twenty aconitine compounds in traditional Chinese medicinal composition preparation
  • Identification method for twenty aconitine compounds in traditional Chinese medicinal composition preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] The preparation of embodiment 1 pharmaceutical capsule of the present invention

[0063] Prescription: Astragalus 450g, Aconite 112.5g, Ginseng 225g, Salvia miltiorrhiza 225g, Tinglizi 150g

[0064] Xiangjia skin 180g Alisma 225g safflower 90g Polygonatum 75g Chenpi 75g Guizhi 90g

[0065] Preparation:

[0066] (1) Reflux extract astragalus, Tinglizi, Alisma, ginseng, and Xiangjia bark according to the above prescription plus 8 times the amount of 70% ethanol for 2 times, the first time for 3 hours, and the second time for 2 hours, combine the extracts, filter After passing through, the filtrate decompresses and reclaims ethanol, and concentrates to a clear paste with a relative density of 1.25 (60°C thermal measurement), for subsequent use;

[0067] (2) Distill cinnamon sticks and tangerine peel to extract volatile oil according to the prescription, filter the aqueous solution after oil extraction, and set aside, add 8 times the amount of water to the residue and dec...

Embodiment 2

[0075] Embodiment 2: the preparation of pharmaceutical tablet of the present invention

[0076] Prescription: Astragalus 150g, Aconite 40g, Codonopsis 225g, Salvia miltiorrhiza 225g, Tinglizi 50g

[0077] Nanwujiapi 180g Alisma 75g Polygonatum 75g Guizhi 30g Safflower 90g Chenpi 25g

[0078] Preparation:

[0079] (1) Weigh Astragalus, Tinglizi, Alisma, Codonopsis, and Acanthopanax bark according to the proportion, add 8 times the amount of 70% ethanol to reflux and extract twice, the first time is 3 hours, the second time is 2 hours, combined extraction liquid, filtered, and the filtrate was decompressed to recover ethanol, concentrated to a clear paste with a relative density of 1.25 (60°C thermal measurement), and set aside;

[0080] (2) Distill cinnamon sticks and tangerine peel to extract volatile oil according to the prescription amount, filter the aqueous solution after oil extraction, and set aside, add 8 times the amount of water to the residue and decoct for 1 hou...

Embodiment 3

[0088] Embodiment 3: medicine of the present invention Granules preparation of

[0089] Prescription: Astragalus 250g, Aconite 112.5g, Codonopsis 200g, Salvia miltiorrhiza 120g, Tinglizi 135g

[0090] Xiangjiapi 150g Alisma 200g Polygonatum 60g Guizhi 75g Safflower 75g Chenpi 60g

[0091] Preparation:

[0092] (1) Extract Astragalus, Tinglizi, Alisma, Codonopsis, and Xiangjiapi according to the above prescription and add 8 times the amount of 70% ethanol to reflux twice, the first time for 3 hours, and the second time for 2 hours, combine the extracts, filter After passing through, the filtrate decompresses and reclaims ethanol, and concentrates to a clear paste with a relative density of 1.28 (60°C thermal measurement), for subsequent use;

[0093] (2) Distill cinnamon sticks and tangerine peel to extract volatile oil according to the prescription, filter the aqueous solution after oil extraction, and set aside, add 6 times the amount of water to the residue and decoct ...

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Abstract

The invention discloses an identification method for twenty aconitine compounds in a traditional Chinese medicinal composition preparation, belonging to the field of pharmaceutical analysis. The identification method comprises the following steps: preparation of a sample solution, chromatogram and mass spectrum analysis, and component identification. C19 diterpenoid alkaloids in the active part of Qiliqiangxin capsules are detected and identified by virtue of UPLC / Q-TOF-MS / MS, so that a strong evidence is provided for research on material base.

Description

technical field [0001] The invention belongs to the field of drug analysis, in particular to a method for identifying active components of traditional Chinese medicines. Background technique [0002] The traditional Chinese medicine composition comprises eleven Chinese herbal medicines such as astragalus, aconite, ginseng, salvia miltiorrhiza, Tinglizi, Alisma, safflower, Polygonatum odoratum, tangerine peel, osmanthus twig, and Xiangjiapi. Aconite (Radix Aconiti Lateralis Preparata) is the dry lateral root of Aconitum genus Ranunculaceae. It is poisonous and has a wide range of pharmacological effects such as analgesic, anti-inflammatory, cardiotonic and anti-cancer. Diterpenoid alkaloids are the main chemical components of aconite, which can be divided into three types according to the structure of substituents: monoester-diterpenoid alkaloids, diester-diterpenoid alkaloids and lipid alkaloids (1ipo-alkaloids), these may also be one of the cardiotonic components of the Ch...

Claims

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Application Information

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IPC IPC(8): G01N30/88
Inventor 乔莉贾继明王宗权王贵金朱慧明
Owner HEBEI YILING MEDICINE INST