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Preparing method of citron pentoxyverine syrup

A technology of pentoxyverine citrate and syrup, which is applied in the field of medicine, can solve problems such as precipitation of pentoxyverine citrate syrup products, and achieve the effects of improving quality stability, convenient operation, and simple method

Active Publication Date: 2015-03-25
YUNNAN PHYTOPHARML
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In order to solve problems such as precipitation of pentoxyverine citrate syrup products during storage, the invention provides a kind of pentoxyverine citrate syrup and a preparation method thereof, which is different from traditional methods and can ensure Pentoxyverine citrate syrup product quality stability, simple process and low cost

Method used

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  • Preparing method of citron pentoxyverine syrup
  • Preparing method of citron pentoxyverine syrup
  • Preparing method of citron pentoxyverine syrup

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] (1) Prepare materials according to the components of the following mass percentages:

[0043]

[0044] The sum of the above components is 100%;

[0045] (2) adding an appropriate amount of purified water to the sucrose in step (1) to form a 68w / w% sucrose solution, heating and boiling for 15 minutes, then filtering, and cooling the filtrate to 38°C to obtain the syrup;

[0046] (3) The pentoxyverine citrate in the step (1) is added with an appropriate amount of purified water to form a 7w / w% pentoxyverine citrate solution;

[0047] (4) adding an appropriate amount of purified water to the thickener in step (1) to form a 12w / w% thickener solution;

[0048] (5) Add 95v / v% ethanol to the preservative in step (1) to make a 7w / w% preservative solution;

[0049] (6) adding the stabilizer in step (1) to purified water to form a 6w / w% stabilizer solution;

[0050] (7) adding 95v / v% ethanol to the flavoring agent in step (1) to form a 18w / w% flavoring agent solution;

[0...

Embodiment 2

[0054] (1) Prepare materials according to the components of the following mass percentages:

[0055]

[0056] The sum of the above components is 100%;

[0057] (2) adding an appropriate amount of purified water to the sucrose in step (1) to form a 72w / w% sucrose solution, heating and boiling for 15 minutes, then filtering, and cooling the filtrate to 42°C to obtain the syrup;

[0058] (3) the pentoxyverine citrate in the step (1) is added with an appropriate amount of purified water to be made into a 5w / w% pentoxyverine citrate solution;

[0059] (4) adding an appropriate amount of purified water to the thickener in step (1) to form a 18w / w% thickener solution;

[0060](5) adding the preservative in step (1) to purified water to form a 9w / w% preservative solution;

[0061] (6) adding the stabilizer in step (1) to purified water to form a 5w / w% stabilizer solution;

[0062] (7) adding 95v / v% ethanol to the flavoring agent in step (1) to make a 22w / w% flavoring agent solut...

Embodiment 3

[0066] (1) Prepare materials according to the components of the following mass percentages:

[0067]

[0068] The sum of the above components is 100%;

[0069] (2) adding an appropriate amount of purified water to the sucrose in step (1) to form a 70w / w% sucrose solution, heating and boiling for 15 minutes, then filtering, and cooling the filtrate to 40°C to obtain the syrup;

[0070] (3) the pentoxyverine citrate in the step (1) plus an appropriate amount of purified water is made into a 6w / w% pentoxyverine citrate solution;

[0071] (4) adding an appropriate amount of purified water to the thickener in step (1) to form a 15w / w% thickener solution;

[0072] (5) Add 95v / v% ethanol to the preservative in step (1) to make 8w / w% preservative solution;

[0073] (6) adding the stabilizer in step (1) to purified water to form a 6w / w% stabilizer solution;

[0074] (7) adding 95v / v% ethanol to the flavoring agent in step (1) to make a 20w / w% flavoring agent solution;

[0075] (...

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Abstract

The invention provides a citron pentoxyverine syrup and a preparing method thereof. The citron pentoxyverine syrup is composed of citron pentoxyverine, sucrose, preservatives, flavoring agents, solubilizer, thickener, 0.015% pigments, stabilizer, 95v / v% ethanol and purified water. The preparing method comprises uniformly mixing syrup solution, citron pentoxyverine solution, thickener solution, preservative solution, stabilizer solution, flavoring agent solution and pigment solution which are prepared in advance; then adding in the solubilizer in a step (1) and performing uniform mixing; then adding in the purified water and performing uniform mixing and filtering to obtain filter liquor, which is namely the citron pentoxyverine syrup. According the preparing method of the citron pentoxyverine syrup, according to a large amount of research, the reasonable processing composition can be screened out; by means of a reasonable sequence of processing and operation, the solubility of the citron pentoxyverine can be enhanced through the solubilizer, and accordingly the product quality and stability can be ensured.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a preparation method of pentoxyverine citrate syrup. Background technique [0002] Pentoxyverine citrate syrup, also known as Kebiqing, is used for dry cough caused by various reasons. The medicine has central and peripheral antitussive effects, and its antitussive effect strength is about 1 / 3 of that of codeine. In addition to the direct inhibitory effect on the respiratory center of the medulla oblongata, it also has a mild atropine-like effect. It can relax the spasm bronchial smooth muscle and reduce airway resistance. [0003] Pentoxyverine citrate is white or off-white crystalline or granular powder; odorless, bitter taste. Soluble in water, soluble in ethanol, slightly soluble in chloroform, almost insoluble in ether. The current standard for pentoxyverine citrate syrup is the national drug standard WS-10001-(HD-0727)-2002, which stipulates that the content of pentoxy...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/205A61K47/26A61P11/14
Inventor 李俊朱光花梅艳杨丽芬
Owner YUNNAN PHYTOPHARML
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