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Biological adhesive vaginal tablet of periplaneta americana extract and preparation method of biological adhesive vaginal tablet

A technology of Periplaneta americana and bioadhesion, which can be applied to diseases, drug combinations, drug delivery, etc., and can solve problems such as inconvenient application

Active Publication Date: 2015-03-25
KUNMING SINOWAY NATURAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, Kangfuxin liquid is used for vaginal administration by using sterilized cotton balls or gauze soaked in Kangfuxin liquid for wet compress, smearing or stuffing, which is inconvenient to apply

Method used

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  • Biological adhesive vaginal tablet of periplaneta americana extract and preparation method of biological adhesive vaginal tablet
  • Biological adhesive vaginal tablet of periplaneta americana extract and preparation method of biological adhesive vaginal tablet
  • Biological adhesive vaginal tablet of periplaneta americana extract and preparation method of biological adhesive vaginal tablet

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 9

[0038] Example 9 Determination of swelling rate

[0039] Put the adhesive sheet into the stainless steel mesh basket and weigh the initial weight W 0 Then, put the basket in a beaker containing 100 mL of distilled water (room temperature 25°C). Take it out at 10, 20, 30, 40, 50, 60, 90 minutes, absorb the moisture on the surface of the basket with filter paper, weigh it, and calculate the weight gain percentage of each adhesive sheet at different times. The formula for calculating weight gain percentage is: weight gain%=((W-W 0 ) / W 0 ]×100%. The weight gain percentage is regressed to a straight line with time, and the slope is the swelling rate of the adhesive sheet.

Embodiment 10

[0040] Example 10 Determination of adhesion

[0041] The mice were killed by severed neck, and the abdominal mucosa was firmly adhered to the platform. In the measurement, the mucosa was moistened with 20μL of distilled water, and then the adhesive sheet was tightly attached to the mucosa layer, and a weight of 200g was added to compress for 2 minutes. Put a hard ring slightly larger than the tablet on the tablet. The hard ring is connected to a plastic cup through a fixed pulley, and water is dripped into the cup with an infusion dropper until the adhesive sheet separates from the mucosa. Weigh the mass of the plastic cup and water, and calculate the adhesion force.

[0042] Table 2 Measurement results of the swelling rate and adhesive force of the bioadhesive vaginal tablets of Periplaneta americana extract

[0043] Example Swelling rate regression equationR2 Swelling rate Adhesion (N) Example 1y=0.0884x+2.95490.97640.08840.39 Example 2y=0.0715x+3.26970.94580.07150.34 Exa...

Embodiment 11

[0044] Example 11 Determination of Release

[0045] According to the release determination method in the second appendix of the Chinese Pharmacopoeia 2010 edition. Choose pH 3.0 PBS1000mL as the release medium, preheat to (37±0.5)℃, and rotate the propeller at 30r.min -1 , At 1, 2, 4, 8, 12, 16, 20, 24h, take out 3mL of release medium, and supplement the same amount of blank medium. The filtrate was placed at room temperature, and the total amino acids were used as the in vitro release index, and the absorbance was measured at 570nm wavelength by the ninhydrin colorimetry.

[0046] By measuring the swelling rate, adhesive force and in vitro release of the bioadhesive vaginal tablets of Periplaneta americana extract, the results show that the bioadhesive is a mixture of high molecular weight chitosan and highly substituted hydroxypropyl cellulose with a ratio of 1 : At 1:1, the prepared adhesive sheet has greater adhesion, appropriate swelling rate and longer adhesion time. The b...

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Abstract

The invention belongs to the technical field of pharmacy, and particularly relates to a biological adhesive vaginal tablet of a periplaneta americana extract and a preparation method of the biological adhesive vaginal tablet. The biological adhesive vaginal tablet is characterized by being prepared from the following raw materials in parts by weight: 15-25 parts of periplaneta americana extract, 40-60 parts of a biological adhesive, 25-35 parts of a filler and 0.1-5 parts of a lubricating agent. Chitosan in the biological adhesive vaginal tablet is a natural amino polysaccharide from marine organisms, and has an inhibiting effect on experimental strains such as staphylococcus epidermidis, staphylococcus aureus, escherichia coli, pseudomonas aeruginosa and monilia albicans. The chitosan not only has excellent biological adhesion performance, but also is capable of opening tight connection of epithelial cells, promoting medicine absorption, and promoting wound healing and repairing, and cooperatively acts on the wounds together with a kangfuxin lotion.

Description

Technical field [0001] The invention belongs to the technical field of pharmacy, and specifically relates to a bioadhesive vaginal tablet of American cockroach extract and a preparation method thereof. Background technique [0002] It is reported in the literature that Kangfuxin Liquid can significantly improve the quality of care in the treatment of cervical cancer (anti-inflammatory and shorten the time of tumor regression) in the treatment of cervical cancer, thereby improving the effect of tumor treatment and the quality of life of patients. It is also reported in the literature that for patients with clinical cervical erosion, vulvar, vagina, and cervical condyloma acuminata, after laser, microwave, phototherapy, and Leep knife treatment, the use of Kangfuxin can promote the healing of the profile, shorten the time of epithelial repair, and have obvious curative effects, and can reduce gland Epithelial hyperplasia. It has clinical application value. Gynecological infection...

Claims

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Application Information

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IPC IPC(8): A61K35/64A61K9/20A61P15/02A61P15/00A61P35/00A61K31/722
CPCA61K9/0034A61K9/2054A61K2236/333A61K2236/51Y02A50/30
Inventor 何道峰郝振平徐溧
Owner KUNMING SINOWAY NATURAL PHARMA
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