Biological adhesive vaginal tablet of periplaneta americana extract and preparation method of biological adhesive vaginal tablet
A technology of Periplaneta americana and bioadhesion, which can be applied to diseases, drug combinations, drug delivery, etc., and can solve problems such as inconvenient application
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 9
[0038] Example 9 Determination of swelling rate
[0039] Put the adhesive sheet into the stainless steel mesh basket and weigh the initial weight W 0 Then, put the basket in a beaker containing 100 mL of distilled water (room temperature 25°C). Take it out at 10, 20, 30, 40, 50, 60, 90 minutes, absorb the moisture on the surface of the basket with filter paper, weigh it, and calculate the weight gain percentage of each adhesive sheet at different times. The formula for calculating weight gain percentage is: weight gain%=((W-W 0 ) / W 0 ]×100%. The weight gain percentage is regressed to a straight line with time, and the slope is the swelling rate of the adhesive sheet.
Embodiment 10
[0040] Example 10 Determination of adhesion
[0041] The mice were killed by severed neck, and the abdominal mucosa was firmly adhered to the platform. In the measurement, the mucosa was moistened with 20μL of distilled water, and then the adhesive sheet was tightly attached to the mucosa layer, and a weight of 200g was added to compress for 2 minutes. Put a hard ring slightly larger than the tablet on the tablet. The hard ring is connected to a plastic cup through a fixed pulley, and water is dripped into the cup with an infusion dropper until the adhesive sheet separates from the mucosa. Weigh the mass of the plastic cup and water, and calculate the adhesion force.
[0042] Table 2 Measurement results of the swelling rate and adhesive force of the bioadhesive vaginal tablets of Periplaneta americana extract
[0043] Example Swelling rate regression equationR2 Swelling rate Adhesion (N) Example 1y=0.0884x+2.95490.97640.08840.39 Example 2y=0.0715x+3.26970.94580.07150.34 Exa...
Embodiment 11
[0044] Example 11 Determination of Release
[0045] According to the release determination method in the second appendix of the Chinese Pharmacopoeia 2010 edition. Choose pH 3.0 PBS1000mL as the release medium, preheat to (37±0.5)℃, and rotate the propeller at 30r.min -1 , At 1, 2, 4, 8, 12, 16, 20, 24h, take out 3mL of release medium, and supplement the same amount of blank medium. The filtrate was placed at room temperature, and the total amino acids were used as the in vitro release index, and the absorbance was measured at 570nm wavelength by the ninhydrin colorimetry.
[0046] By measuring the swelling rate, adhesive force and in vitro release of the bioadhesive vaginal tablets of Periplaneta americana extract, the results show that the bioadhesive is a mixture of high molecular weight chitosan and highly substituted hydroxypropyl cellulose with a ratio of 1 : At 1:1, the prepared adhesive sheet has greater adhesion, appropriate swelling rate and longer adhesion time. The b...
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com