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Novel schiff base vanadium oxide compound as well as preparation method and application thereof

A kind of rare Buddha base and compound technology, applied in the field of new rare Buddha base vanadyl compound and its preparation, can solve the problems of inconvenient life for patients, diabetes side effects without effective treatment, etc., and achieve excellent hypoglycemic activity effect

Inactive Publication Date: 2015-03-25
YUNNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The current method of treating type 1 diabetes is mainly to inject insulin into the patient every day, which brings a lot of inconvenience and pain to the life and work of the patient.
However, the drugs currently on the market for the treatment of type Ⅱ diabetes mainly include sulfonylureas, sulfonamides, metformin and other drugs, which have no effective treatment for the side effects caused by diabetes.

Method used

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  • Novel schiff base vanadium oxide compound as well as preparation method and application thereof
  • Novel schiff base vanadium oxide compound as well as preparation method and application thereof
  • Novel schiff base vanadium oxide compound as well as preparation method and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0020] (1) Take 4,5-dichloro-o-phenylenediamine and dissolve it in ethanol solution, the molar volume ratio of 4,5-dichloro-o-phenylenediamine and ethanol is 1:30mmol / ml; take salicylaldehyde and dissolve it in ethanol solution In the method, the molar volume ratio of salicylaldehyde to ethanol is 12:15mmol / ml; drop the salicylaldehyde solution into the ethanol solution in a constant temperature water bath / oil bath at 50°C, and 4,5-dichloro-o-phenylenediamine The molar ratio with salicylaldehyde is 1:12, mixed, and the reaction is refluxed for 5 hours, a yellow flocculent precipitate is precipitated, cooled, filtered with suction, recrystallized in ethanol, the precipitate is obtained, dried, and the ligand is obtained;

[0021] (2) The ligand obtained in step (1) is dissolved in acetonitrile to obtain a ligand solution, and the molar volume ratio of the ligand to acetonitrile is 0.5:13mmol / ml; VOSO 4 ·5H 2 O is dissolved in water to obtain a metal salt solution, VOSO 4 ·5H ...

Embodiment 2

[0023] (1) Dissolve 4,5-dichloro-o-phenylenediamine in ethanol solution, the molar volume ratio of 4,5-dichloro-o-phenylenediamine to ethanol is 5:30mmol / ml; dissolve salicylaldehyde in ethanol solution In the method, the molar volume ratio of salicylaldehyde to ethanol is 6:15mmol / ml; drop the salicylaldehyde solution into the ethanol solution in a constant temperature water bath / oil bath at 70°C, and 4,5-dichloro-o-phenylenediamine The molar ratio with salicylaldehyde is 5:6, mixed, and the reaction is refluxed for 3 hours, a yellow flocculent precipitate is precipitated, cooled, suction filtered, recrystallized in ethanol to obtain a precipitate, dried, and the ligand is obtained;

[0024] (2) The ligand obtained in step (1) is dissolved in acetonitrile to obtain a ligand solution, and the molar volume ratio of the ligand to acetonitrile is 2:13mmol / ml; VOSO 4 ·5H 2 O is dissolved in water to obtain a metal salt solution, VOSO 4 ·5H 2 The molar volume ratio of O to water...

Embodiment 3

[0026] (1) Dissolve 4,5-dichloro-o-phenylenediamine (3mmol, 0.51g) in 30mL of ethanol solution, and dissolve salicylaldehyde (9mmol, 1.05g) in 15mL of ethanol solution. Add the salicylaldehyde solution drop by drop in the bath and mix the two. The reaction was refluxed for 4 hours, and yellow flocculent precipitates were precipitated, cooled and filtered with suction. Recrystallization was carried out in ethanol to obtain a precipitate, which was dried to obtain a ligand.

[0027] (2) The ligand (1mmol, 0.383g) obtained above was dissolved in 13mL MeCN, VOSO 4 ·5H 2 O (1 mmol, 0.254 g) was dissolved in 20 mL of water. Under stirring, add the metal salt solution dropwise into the ligand solution, stir for 30 minutes, a brown precipitate is produced, filter, dissolve the precipitate in DMSO, and keep the filtrate at the same time. After 30 days, the DMSO solution precipitates yellow massive complex crystals, suitable for X- X-ray single crystal diffraction. The yield was 80...

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Abstract

The invention discloses a novel schiff base vanadium oxide compound as well as a preparation method and application thereof. The novel schiff base vanadium oxide compound is named N,N'-bis(salicylidene)-4,5-dichloro-1,2-phenylenediamine shrinked-diamine oxovanadium and has a molecular formula of [C20H12Cl2N2O3V] and molecular weight FW equal to 450.16, and a chemical structural formula of the novel schiff base vanadium oxide compound is as shown in the specification. The novel schiff base vanadium oxide compound disclosed by the invention has excellent hypoglycemic activity and can be used for preparing a drug for treating diabetes.

Description

technical field [0001] The invention relates to the technical field of medicinal chemistry, and in particular to a novel fernandine vanadyl compound and its preparation method and application. Background technique [0002] Diabetes mellitus is a chronic metabolic disease caused by lack of insulin, and its main clinical feature is that the glucose content in the patient's blood is higher than that of the normal population. According to statistics, there are currently about 35 million diabetic patients in the world, and this number may double by 2030. Diabetes can be divided into type I and type II according to pathological characteristics. Type Ⅰ is caused by insufficient insulin secretion in the body, and exogenous insulin supplementation is usually used for treatment; type Ⅱ is caused by the resistance of target cells to insulin, which mostly occurs in obese people, and there is currently no safe and effective treatment. The current method of treating type 1 diabetes is m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07F9/00A61K31/28A61P3/10
Inventor 谢明进祝明蓉赵琦华卢春梅李玲高李辉
Owner YUNNAN UNIV
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